JAMA Neurol:视网膜神经纤维层厚度与认知衰退

2018-06-27 zhangfan MedSci原创

研究认为,对于无神经退行性疾病人群,较薄的视网膜神经纤维层厚度与认知能力较差以及后继认知能力衰退相关

认知衰退是痴呆的先兆,近日研究人员在健康人群中考察了视网膜神经纤维层(RNFL) 厚度测量对认知衰退风险的预测效果。

40-69岁人群接受了视网膜光学相干断层成像、体格检查和问卷调查。参与者基线进行了4项基本认知测试,大约3年后,重复这些测试。通过多变量逻辑回归模型考察RNFL厚度与认知功能的相关性。重点考察基线认知测试得分最低1/5人群以及随访认知得分显著降低人群。

总计32038名参与者,平均年龄56.0岁,女性占53.6%。基线时,RNFL较薄人群的认知表现较差。多变量分析显示RNFL厚度最薄1/5人群,其至少1项认知测试失败的可能性增加11%。1251名参与者接受了3年后随访,RNFL厚度最薄1/5-2/5人群其至少一项认知评分显著降低的风险增加2倍(RNFL厚度最薄2/5风险比值比为1.92,最薄1/5人群的风险比值比为2.08)。

研究认为,对于无神经退行性疾病人群,较薄的视网膜神经纤维层厚度与认知能力较差以及后继认知能力衰退相关。

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    2018-08-14 yinhl1978
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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327431, encodeId=25f832e43147, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jun 27 12:56:35 CST 2018, time=2018-06-27, status=1, ipAttribution=)]
    2018-08-31 amyloid
  5. 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    2018-06-29 zutt
  6. 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  7. 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  8. [GetPortalCommentsPageByObjectIdResponse(id=1801565, encodeId=1c0b180156541, content=<a href='/topic/show?id=9cd690e860a' target=_blank style='color:#2F92EE;'>#视网膜神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90786, encryptionId=9cd690e860a, topicName=视网膜神经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2b4297, createdName=徐岩, createdTime=Fri Aug 03 12:14:00 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2018089, encodeId=d58820180896f, content=<a href='/topic/show?id=8adc90e9115' target=_blank style='color:#2F92EE;'>#视网膜神经纤维层厚度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90791, encryptionId=8adc90e9115, topicName=视网膜神经纤维层厚度)], attachment=null, authenticateStatus=null, createdAvatar=, 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content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epLWLHOOeaLiabibyplZBrSPxxnWVR7dHMFsIgbXGnsulAjGv3AaicTYUvNdll7QLqeFERqBKbReQ0VQ/132, createdBy=f6471852173, createdName=毛毛阳阳, createdTime=Wed Jun 27 13:06:52 CST 2018, time=2018-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327434, encodeId=5add32e434c5, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Wed Jun 27 12:57:14 CST 2018, time=2018-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327431, encodeId=25f832e43147, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jun 27 12:56:35 CST 2018, time=2018-06-27, status=1, ipAttribution=)]
    2018-06-27 毛毛阳阳

    学习了

    0

  9. 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content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epLWLHOOeaLiabibyplZBrSPxxnWVR7dHMFsIgbXGnsulAjGv3AaicTYUvNdll7QLqeFERqBKbReQ0VQ/132, createdBy=f6471852173, createdName=毛毛阳阳, createdTime=Wed Jun 27 13:06:52 CST 2018, time=2018-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327434, encodeId=5add32e434c5, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Wed Jun 27 12:57:14 CST 2018, time=2018-06-27, status=1, 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    2018-06-27 wzb521zf

    一起学习学习

    0

  10. 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content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epLWLHOOeaLiabibyplZBrSPxxnWVR7dHMFsIgbXGnsulAjGv3AaicTYUvNdll7QLqeFERqBKbReQ0VQ/132, createdBy=f6471852173, createdName=毛毛阳阳, createdTime=Wed Jun 27 13:06:52 CST 2018, time=2018-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327434, encodeId=5add32e434c5, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Wed Jun 27 12:57:14 CST 2018, time=2018-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327431, encodeId=25f832e43147, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jun 27 12:56:35 CST 2018, time=2018-06-27, status=1, ipAttribution=)]
    2018-06-27 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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