JCC:青年人炎症性肠病患者心理疾病发病率和疾病感知的关联

2019-09-02 不详 MedSci原创

患有炎症性肠病的年轻人[IBD]的心理疾病发病率明显增加。疾病认知可能是一个重要因素。这项研究旨在描述心理疾病发病率的普遍性和严重程度,并检查基线疾病认知与焦虑,抑郁和健康相关的生活质量[HRQoL]之间的关系。

背景和目的
患有炎症性肠病的年轻人[IBD]的心理疾病发病率明显增加。疾病认知可能是一个重要因素。这项研究旨在描述心理疾病发病率的普遍性和严重程度,并检查基线疾病认知与焦虑,抑郁和健康相关的生活质量[HRQoL]之间的关系。

方法
研究人员要求IBD患者[ n = 121]在基线和随访时完成了焦虑,抑郁,HRQoL和疾病感知[IPQ-R]的测量评分。

结果
在基线的121名患者中[中位年龄19.3岁,40%女性,62%克罗恩病,73%临床缓解],55%报告焦虑/抑郁症状升高,83%报告低HRQoL症状。基线时的负性疾病感知与基线和随访时更大的焦虑,抑郁和更低的HRQoL显着相关。在基线的回归分析中,对IBD周期性更强的感知的IPQ-R域是焦虑的独立预测因子,并且IBD的更大感知情绪影响是焦虑,抑郁和HRQoL的独立预测因子。女性和临床复发也是HRQoL降低的独立预测因子。

结论
IBD年轻人的心理疾病发病率高。患有负面疾病的感知,女性和患有活动性疾病是心理疾病风险最高的人群。

原始出处:

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1798860, encodeId=8c631e9886031, content=<a href='/topic/show?id=a265e065469' target=_blank style='color:#2F92EE;'>#疾病发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70654, encryptionId=a265e065469, topicName=疾病发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b27406, createdName=syscxl, createdTime=Wed Jan 15 04:17:00 CST 2020, time=2020-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823572, encodeId=d63718235e281, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sat Nov 16 05:17:00 CST 2019, time=2019-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1916811, encodeId=3ef1191681102, content=<a href='/topic/show?id=f24198994a6' target=_blank style='color:#2F92EE;'>#青年人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98994, encryptionId=f24198994a6, topicName=青年人)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=284b425, createdName=zll0625, createdTime=Tue Oct 15 07:17:00 CST 2019, time=2019-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547258, encodeId=aaca154e25847, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Wed Sep 04 02:17:00 CST 2019, time=2019-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600023, encodeId=0be5160002339, content=<a href='/topic/show?id=508e6e03203' target=_blank style='color:#2F92EE;'>#炎症性肠病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67032, encryptionId=508e6e03203, topicName=炎症性肠病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9fa18776644, createdName=huangshifeng, createdTime=Wed Sep 04 02:17:00 CST 2019, time=2019-09-04, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1798860, encodeId=8c631e9886031, content=<a href='/topic/show?id=a265e065469' target=_blank style='color:#2F92EE;'>#疾病发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70654, encryptionId=a265e065469, topicName=疾病发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b27406, createdName=syscxl, createdTime=Wed Jan 15 04:17:00 CST 2020, time=2020-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823572, encodeId=d63718235e281, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sat Nov 16 05:17:00 CST 2019, time=2019-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1916811, encodeId=3ef1191681102, content=<a href='/topic/show?id=f24198994a6' target=_blank style='color:#2F92EE;'>#青年人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98994, encryptionId=f24198994a6, topicName=青年人)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=284b425, createdName=zll0625, createdTime=Tue Oct 15 07:17:00 CST 2019, time=2019-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547258, encodeId=aaca154e25847, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Wed Sep 04 02:17:00 CST 2019, time=2019-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600023, encodeId=0be5160002339, content=<a href='/topic/show?id=508e6e03203' target=_blank style='color:#2F92EE;'>#炎症性肠病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67032, encryptionId=508e6e03203, topicName=炎症性肠病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9fa18776644, createdName=huangshifeng, createdTime=Wed Sep 04 02:17:00 CST 2019, time=2019-09-04, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1798860, encodeId=8c631e9886031, content=<a href='/topic/show?id=a265e065469' target=_blank style='color:#2F92EE;'>#疾病发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70654, encryptionId=a265e065469, topicName=疾病发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b27406, createdName=syscxl, createdTime=Wed Jan 15 04:17:00 CST 2020, time=2020-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823572, encodeId=d63718235e281, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sat Nov 16 05:17:00 CST 2019, time=2019-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1916811, encodeId=3ef1191681102, content=<a href='/topic/show?id=f24198994a6' target=_blank style='color:#2F92EE;'>#青年人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98994, encryptionId=f24198994a6, topicName=青年人)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=284b425, createdName=zll0625, createdTime=Tue Oct 15 07:17:00 CST 2019, time=2019-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547258, encodeId=aaca154e25847, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Wed Sep 04 02:17:00 CST 2019, time=2019-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600023, encodeId=0be5160002339, content=<a href='/topic/show?id=508e6e03203' target=_blank style='color:#2F92EE;'>#炎症性肠病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67032, encryptionId=508e6e03203, topicName=炎症性肠病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9fa18776644, createdName=huangshifeng, createdTime=Wed Sep 04 02:17:00 CST 2019, time=2019-09-04, status=1, ipAttribution=)]
    2019-10-15 zll0625
  4. [GetPortalCommentsPageByObjectIdResponse(id=1798860, encodeId=8c631e9886031, content=<a href='/topic/show?id=a265e065469' target=_blank style='color:#2F92EE;'>#疾病发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70654, encryptionId=a265e065469, topicName=疾病发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b27406, createdName=syscxl, createdTime=Wed Jan 15 04:17:00 CST 2020, time=2020-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823572, encodeId=d63718235e281, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sat Nov 16 05:17:00 CST 2019, time=2019-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1916811, encodeId=3ef1191681102, content=<a href='/topic/show?id=f24198994a6' target=_blank style='color:#2F92EE;'>#青年人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98994, encryptionId=f24198994a6, topicName=青年人)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=284b425, createdName=zll0625, createdTime=Tue Oct 15 07:17:00 CST 2019, time=2019-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547258, encodeId=aaca154e25847, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Wed Sep 04 02:17:00 CST 2019, time=2019-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600023, encodeId=0be5160002339, content=<a href='/topic/show?id=508e6e03203' target=_blank style='color:#2F92EE;'>#炎症性肠病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67032, encryptionId=508e6e03203, topicName=炎症性肠病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9fa18776644, createdName=huangshifeng, createdTime=Wed Sep 04 02:17:00 CST 2019, time=2019-09-04, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1798860, encodeId=8c631e9886031, content=<a href='/topic/show?id=a265e065469' target=_blank style='color:#2F92EE;'>#疾病发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70654, encryptionId=a265e065469, topicName=疾病发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b27406, createdName=syscxl, createdTime=Wed Jan 15 04:17:00 CST 2020, time=2020-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823572, encodeId=d63718235e281, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sat Nov 16 05:17:00 CST 2019, time=2019-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1916811, encodeId=3ef1191681102, content=<a href='/topic/show?id=f24198994a6' target=_blank style='color:#2F92EE;'>#青年人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98994, encryptionId=f24198994a6, topicName=青年人)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=284b425, createdName=zll0625, createdTime=Tue Oct 15 07:17:00 CST 2019, time=2019-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547258, encodeId=aaca154e25847, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Wed Sep 04 02:17:00 CST 2019, time=2019-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600023, encodeId=0be5160002339, content=<a href='/topic/show?id=508e6e03203' target=_blank style='color:#2F92EE;'>#炎症性肠病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67032, encryptionId=508e6e03203, topicName=炎症性肠病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9fa18776644, createdName=huangshifeng, createdTime=Wed Sep 04 02:17:00 CST 2019, time=2019-09-04, status=1, ipAttribution=)]

相关资讯

Clin Gastroenterology H:他汀类药物可以改善原发性硬化性胆管炎患者的预后

越来越多的证据表明他汀类药物可以使患有慢性肝病的患者受益,但是这种优异的影响尚未在原发性硬化性胆管炎(PSC)患者中进行过研究。本研究旨在探究他汀类药物对PSC患者的影响。

JCC:维持治疗期间较高的Vedolizumab谷浓度与炎症性肠病的无皮质类固醇缓解相关

Vedolizumab是一种抗-α4β7生物制剂,目前已被批准用于治疗溃疡性结肠炎[UC]和克罗恩病[CD]。本项研究的目的是探究维多珠单抗浓度与炎症性肠病患者无激素缓解期的关系。

Gastric Cancer:CRP /前白蛋白是一种新的炎症指数,可以用于预测胃癌患者根治性切除术后的临床复发

血清前白蛋白(PALB)可预测胃癌患者的预后(GC)。然而,C反应蛋白和PALB(CRP / PALB)组合的预后价值仍不清楚。因此,本项研究旨在探究二者的关系。

JCC: 与散发性结肠癌相比,IBD相关的结肠癌在DNA甲基化和基因表达谱方面有所不同

由于溃疡性结肠炎[UC]相关结直肠癌[CRC]和散发性CRC在临床表现和分子特征上有所不同,本项研究试图评估这两种不同结直肠癌中的DNA甲基化对基因表达影响的差异。

JCC: 低剂量甲氨蝶呤与抗TNF联合治疗炎症性肠病与使用大剂量甲氨蝶呤具有相似的疗效

甲氨蝶呤[MTX]是一种众所周知的免疫调节剂,可以用于治疗炎症性肠病[IBD],并且通常与生物制剂联合使用。但目前尚未确定用于联合治疗的理想MTX剂量。本研究旨在研究不同剂量的MTX在IBD中与抗TNF药物一起使用时对疗效和安全性结果的影响。

JCC: 早发性或长期炎症性肠病患者肠粘膜γδT细胞的表征及其与临床表现关系

炎症性肠病[IBD]是一种慢性炎性肠道疾病,且没有明确的病因。传统上,失调的适应性免疫反应发挥重要作用,由于γδT细胞的众所周知的可塑性,我们研究了它们与健康受试者相比在早发和长期IBD患者的肠粘膜中的发生率,表型特征和效应功能。