PLos One:肥胖的心血管患者死亡率更低?科学家们来辟谣

2017-12-09 海北 MedSci原创

已有的一些研究表明,肥胖可能会给心血管疾病(CVD)患者带来生存优势。这种肥胖“悖论”经常是在流行疾病的背景下进行研究的。

已有的一些研究表明,肥胖可能会给心血管疾病(CVD)患者带来生存优势。这种肥胖悖论经常是在流行疾病的背景下进行研究的。在疾病过程中,与疾病相关的体重减轻以及选择性生存的混淆是现阶段面临的问题。为了解决这个问题,来自纽约大学的研究人员探究了CVD患者中肥胖与死亡率之间的关联,并将这些结果与基于普遍疾病的结果进行比较。

研究人员使用了健康和退休研究的数据。这是一项正在进行的,具有全国代表性的纵向调查,涉及美国1992年开始的50岁及以上的成年人,并与医疗保险索赔相关联。研究人员使用Cox比例风险模型来估计具有特定CVD诊断的人中体重状况与死亡率之间的关联。 CVD诊断是通过自我报告的调查数据以及医疗保险索赔来确定的。

研究人员检查了心肌梗塞,充血性心力衰竭,中风和缺血性心脏病。在流行疾病模型中,研究人员一直观察到强烈而显着的肥胖症悖论(相对于正常体重人群,肥胖I类的死亡危险性降低18-36%),这与之前的发现一致。然而,在相同数据相同条件的事件疾病模型中,没有以上死亡率降低的证据。使用基于调查和基于声明的诊断模型的结果基本一致。

因此,在CVD患者中,研究人员没有发现肥胖有生存优势的证据。


原始出处:

Virginia W. Chang et al. The obesity paradox and incident cardiovascular disease: A population-based studyPLOS ONE, 2017; 12 (12): e0188636 DOI: 10.1371/journal.pone.0188636


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    2018-10-15 feather87
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    2017-12-11 wzb521zf

    一起学习一下

    0

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    2017-12-10 1391e9f2a7m

    好文章.认真学习

    0

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    2017-12-09 有备才能无患

    已有的一些研究表明.肥胖可能会给心血管疾病(CVD)患者带来生存优势.这种肥胖[悖论"经常是在流行疾病的背景下进行研究的.在疾病过程中.与疾病相关的体重减轻以及选择性生存的混淆是现阶段面临的问题.

    0

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