肿瘤科

订阅

MedSci主页 / 所有栏目 / 肿瘤科

J Thorac Cardiovasc Surg：IA期肺腺癌肺段切除与肺叶切除疗效相似

2013-11-07 萧弈 dxy

IA期肺腺癌肺叶切除
关注

对于肺叶切除和肺段切除临床IA期肺腺癌的肿瘤学结果是目前胸外科医生争论的焦点，但这方面数据仍比较缺乏。针对这种情况，来自日本广岛大学肿瘤外科的Morihito Okada教授等人进行了一项研究，研究结果在线发表于2013年8月23日的《心胸外科杂志》(J Thorac Cardiovasc Surg)杂志上。作者发现肺段切除适合于临床IA期肺腺癌，与那些标准肺叶切除术患者生存相似。【原文下载】该研



对于肺叶切除和肺段切除临床IA期肺腺癌的肿瘤学结果是目前胸外科医生争论的焦点，但这方面数据仍比较缺乏。针对这种情况，来自日本广岛大学肿瘤外科的Morihito Okada教授等人进行了一项研究，研究结果在线发表于2013年8月23日的《心胸外科杂志》(J Thorac Cardiovasc Surg)杂志上。作者发现肺段切除适合于临床IA期肺腺癌，与那些标准肺叶切除术患者生存相似。【原文下载】

该研究回顾性分析618例中481例连续临床IA期肺腺癌患者，术前行高分辨率计算机断层扫描和F-18-脱氧正电子发射断层扫描/计算层析成像后接受肺叶切除或肺段切除。排除137例行楔形切除术患者。对所有行肺叶切除（n=383)和肺段切除(n=98）的患者及其手术结果进行了倾向分数匹配分析

研究结果表明，无复发生存（RFS）和总生存（OS）在肺叶切除(3年RFS，87.3%；3年OS，94.1%)和肺段切除（3年RFS，91.4%；风险比[HR]0.57；95%可信区间[CI]0.27-1.20；P=0.14；3年OS，96.9%；HR=0.49；95%CI，0.17-1.38；P=0.18）患者之间未见明显差异。临床因素这两个治疗组之间存在显著差异如实体肿瘤大小(P<.001),最大标准摄取值(SUVmax)(P<.001),和肿瘤位置(左右侧，P=0.005；肺叶，P=0.001)。81例配对倾向分数匹配分析发现变量包括如年龄、性别、实体肿瘤大小、SUVmax、左右侧和肺叶，RFS和OS在肺叶切除（3年RFS，92.9%；3年OS，93.2%)和肺段切除(3年RFS，90.9%；3年OS，95.7%)之间相似。

该研究发现，肺段切除适合于临床IA期肺腺癌，与那些标准肺叶切除术患者生存相似。

原文出处

Tsutani Y, Miyata Y, Nakayama H, Okumura S, Adachi S, Yoshimura M, Okada M.Oncologic outcomes of segmentectomy compared with lobectomy for clinical stage IA lung adenocarcinoma: propensity score-matched analysis in a multicenter study.J Thorac Cardiovasc Surg. 2013 Aug;【原文下载】

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (3)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2056973, encodeId=75ce20569e31a, content=<a href='/topic/show?id=a19b1e4042f' target=_blank style='color:#2F92EE;'>#THORAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17404, encryptionId=a19b1e4042f, topicName=THORAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=052a130, createdName=yyj062, createdTime=Sat Nov 09 08:08:00 CST 2013, time=2013-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1938261, encodeId=73e21938261c7, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Sep 24 13:08:00 CST 2014, time=2014-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556423, encodeId=c68b15564233c, content=<a href='/topic/show?id=a9b0820898c' target=_blank style='color:#2F92EE;'>#肺叶切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82089, encryptionId=a9b0820898c, topicName=肺叶切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=727d14772225, createdName=zhangj7113, createdTime=Sat Nov 09 04:08:00 CST 2013, time=2013-11-09, status=1, ipAttribution=)]
    2013-11-09 yyj062

    #THORAC#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2056973, encodeId=75ce20569e31a, content=<a href='/topic/show?id=a19b1e4042f' target=_blank style='color:#2F92EE;'>#THORAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17404, encryptionId=a19b1e4042f, topicName=THORAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=052a130, createdName=yyj062, createdTime=Sat Nov 09 08:08:00 CST 2013, time=2013-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1938261, encodeId=73e21938261c7, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Sep 24 13:08:00 CST 2014, time=2014-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556423, encodeId=c68b15564233c, content=<a href='/topic/show?id=a9b0820898c' target=_blank style='color:#2F92EE;'>#肺叶切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82089, encryptionId=a9b0820898c, topicName=肺叶切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=727d14772225, createdName=zhangj7113, createdTime=Sat Nov 09 04:08:00 CST 2013, time=2013-11-09, status=1, ipAttribution=)]
    2014-09-24 一叶知秋

    #ASC#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2056973, encodeId=75ce20569e31a, content=<a href='/topic/show?id=a19b1e4042f' target=_blank style='color:#2F92EE;'>#THORAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17404, encryptionId=a19b1e4042f, topicName=THORAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=052a130, createdName=yyj062, createdTime=Sat Nov 09 08:08:00 CST 2013, time=2013-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1938261, encodeId=73e21938261c7, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Sep 24 13:08:00 CST 2014, time=2014-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556423, encodeId=c68b15564233c, content=<a href='/topic/show?id=a9b0820898c' target=_blank style='color:#2F92EE;'>#肺叶切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82089, encryptionId=a9b0820898c, topicName=肺叶切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=727d14772225, createdName=zhangj7113, createdTime=Sat Nov 09 04:08:00 CST 2013, time=2013-11-09, status=1, ipAttribution=)]
    2013-11-09 zhangj7113

    #肺叶切除#

    0