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J Endod：抗微生物肽LL-37对牙髓干细胞增殖和分化的影响

2017-10-18 lishiting MedSci原创

牙髓干细胞抗微生物肽增殖分化
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这篇研究的目的是为了在体外评估5和10 μg/mL LL-37的生物相容性以及它对牙髓干细胞(DPSCs)向成牙本质细胞样细胞分化的影响。

这篇研究的目的是为了在体外评估5和10 μg/mL LL-37的生物相容性以及它对牙髓干细胞(DPSCs)向成牙本质细胞样细胞分化的影响。

研究对DPSCs分别施加5和10 μg/mL LL-37后，检测了细胞活力、基因毒性、一氧化氮产量、细胞周期、牙本质涎磷蛋白(DSPP)产物以及DSPP基因的表达情况变化。

结果显示，5和10 μg/mL浓度的LL-37没有细胞毒性，并且可以普遍上调细胞活性，特别是在培养的第3天(P < .05)。然而，LL-37在任何一个浓度下都未曾明显改变一氧化氮产量。细胞周期的分析显示，10 μg/mL的LL-37在G0/G1期阻断细胞增殖(P < .05)。对照组在细胞周期的其他阶段展现出更多的细胞数量(P < .05)。同样，10 μg/mL的LL-37组DSPP基因和蛋白的表达也明显高于其他组(P < .05)。

结论：这些结果表明，LL-37在受检浓度表现出良好的生物相容性，并且它可以增加活性细胞的数量，特别是在初始期。10 μg/mL的浓度阻碍细胞周期，但是可以促进DSPP基因和蛋白的表达，表明LL-37肽可以促进成牙本质细胞分化。

原始出处：

Milhan NVM， de Barros PP， et al. The Antimicrobial Peptide LL-37 as a Possible Adjunct for the Proliferation and Differentiation of Dental Pulp Stem Cells. J Endod. 2017 Oct 12. pii： S0099-2399(17)30954-8. doi： 10.1016/j.joen.2017.08.010.

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    2018-03-14 wjcjjian

    #微生物#

    0

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    2018-03-14 jxrzshh

    #牙髓#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1824840, encodeId=d3bc1824840fe, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Wed Mar 14 18:40:00 CST 2018, time=2018-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669608, encodeId=bc4e16696086a, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Wed Mar 14 16:40:00 CST 2018, time=2018-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540906, encodeId=7973154090654, content=<a href='/topic/show?id=ba2ee78630b' target=_blank style='color:#2F92EE;'>#细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77863, encryptionId=ba2ee78630b, topicName=细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f58613291856, createdName=晓辰, createdTime=Fri Oct 20 13:40:00 CST 2017, time=2017-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544881, encodeId=5317154488185, content=<a href='/topic/show?id=f5576e67147' target=_blank style='color:#2F92EE;'>#牙髓干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67671, encryptionId=f5576e67147, topicName=牙髓干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=841913671773, createdName=ms6519009802973839, createdTime=Fri Oct 20 13:40:00 CST 2017, time=2017-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254405, encodeId=4c6025440524, content=不错的文章值得一读., beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Thu Oct 19 22:46:34 CST 2017, time=2017-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254245, encodeId=c6022542459d, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Oct 19 08:28:32 CST 2017, time=2017-10-19, status=1, ipAttribution=)]
    2017-10-20 晓辰

    #细胞增殖#

    0

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    2017-10-20 ms6519009802973839

    #牙髓干细胞#

    0

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    2017-10-19 1e1b8538m79(暂无匿称)

    不错的文章值得一读.

    0

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    2017-10-19 1ddf0692m34(暂无匿称)

    学习了.涨知识

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