JACC:硝普钠可以改善重度主动脉瓣狭窄患者的血流动力学水平

2017-09-06 MedSci MedSci原创

低梯度的重度主动脉瓣狭窄(LGSAS)伴保留型射血分数的病理机制尚未阐明,近日,在国际心血管权威杂志JACC上发表了一篇旨在硝普钠对LGSAS伴保留型射血分数患者的急性血流动力学影响的研究。本研究纳入了41例有临床症状的LGSAS伴保留型射血分数的患者(25例低血流[LF],SVI≤35 ml/m2;16例血流正常[NF]),并在接受硝普钠治疗前后对其血流动力学水平进行评估。在随访开始时,LF患者

低梯度的重度主动脉瓣狭窄(LGSAS)伴保留型射血分数的病理机制尚未阐明,近日,在国际心血管权威杂志JACC上发表了一篇旨在评估硝普钠对LGSAS伴保留型射血分数患者的急性血流动力学影响的研究。本研究纳入了41例有临床症状的LGSAS伴保留型射血分数的患者(25例低血流[LF],SVI≤35 ml/m2;16例血流正常[NF]),并在接受硝普钠治疗前后对其血流动力学水平进行评估。在随访开始时,LF患者的整体动脉顺应性更低(0.36 ± 0.12 ml/m2/mm Hg vs. 0.48 ± 0.16 ml/m2/mm Hg; p = 0.01),而动脉弹性更好(2.77 ± 0.84 mm Hg · m2/ml vs. 1.89 ± 0.82 mm Hg · m2/ml; p = 0.002)。在所有患者中,硝普钠可以降低动脉弹性、左室充盈压力和肺动脉压力,并提高动脉顺应性(p<0.05)。研究结果显示,硝普钠可以降低LGSAS伴保留型射血分数患者的后负荷和左室充盈压,使25%的重度主动脉瓣狭窄患者恢复至中度。原始出处:James W et al.Hemodynamic Resp

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    2018-02-04 hbwxf
  3. 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    2017-09-13 大爰

    学习了谢谢分享!!

    0

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    2017-09-06 清风拂面

    谢谢分享.学习了

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