Neurology:抗癫痫药物治疗响应人群血浆胃饥饿素含量增加

2018-05-29 zhangfan MedSci原创

研究认为血浆胃饥饿素以及去乙酰化胃饥饿素是癫痫患者药物治疗响应的标志

近日研究人员就儿童癫痫患者血浆内源性脑肠肽ghrelin(胃饥饿素)及去乙酰化ghrelin水平与抗癫痫药物治疗应答之间的关系进行了考察。

114名患儿参与研究,其中抗癫痫药物应答患儿77人,无应答患儿37人,研究同时招募了59名对照志愿者,通过免疫分析法对参与者血浆ghrelin及去乙酰化ghrelin含量进行检测。

研究发现,相比于对照组,治疗应答人群血浆ghrelin (+94%; p < 0.001, Dunn test)及去乙酰化ghrelin(+55%; p < 0.001)含量显著增加,但非应答患儿2种激素的含量与对照组差异不显著。相比于治疗无应答人群,治疗应答人群血浆ghrelin及去乙酰化ghrelin含量分别增加126%及29%。

研究认为血浆胃饥饿素以及去乙酰化胃饥饿素是癫痫患者药物治疗响应的标志。

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    2018-09-18 yinhl1978
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