CLIN CANCER RES:骨骼肌损失可以作为局部晚期宫颈癌患者预后的标志

2018-10-30 MedSci MedSci原创

CLIN CANCER RES近期发表了一篇文章,研究同步放化疗(CCRT)期间身体成分变化与局部晚期宫颈癌(LACC)患者预后之间的关系。

CLIN CANCER RES近期发表了一篇文章,研究同步放化疗(CCRT)期间身体成分变化与局部晚期宫颈癌(LACC)患者预后之间的关系。

作者分析了在2004年至2015年间接受治疗的245例LACC患者的治疗前和治疗后CT图像。通过L3椎骨水平的两组CT图像测量骨骼肌指数(SMI)和密度(SMD),皮下脂肪指数(SATI)和内脏脂肪指数(VATI)。使用已知的临界点定义肌肉减少症和低SMD。使用Cox回归模型分析总生存(OS)和癌症特异性生存(CSS)的预测因素。中位随访时间为62.7个月。245名患者中,有127名(51.8%)存在治疗前肌肉减少,154名(62.9%)患有低SMD。CCRT期间SMI没有显着下降,0.6%/ 150天。然而,CCRT期间SMI损失> 10.0%/ 150天与OS和CSS不良独立相关。治疗前肌肉减少和CCRT期间SMD,SATI和VATI的变化与生存无关。

文章最后认为,临床实践中可以将骨骼肌水平作为预测LACC患者的预后的标志。尚需要进一步的研究来确定是否可以通过保留骨骼肌质量从而提高患者生存率。

原始出处:

Jie Lee, Chih-Long Chang, et al. Skeletal Muscle Loss Is an Imaging Biomarker of Outcome after Definitive Chemoradiotherapy for Locally Advanced Cervical Cancer. CLIN CANCER RES. October 2018 doi: 10.1158/1078-0432.CCR-18-0788

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    2018-11-01 chg122
  5. [GetPortalCommentsPageByObjectIdResponse(id=1692017, encodeId=6a3e169201e0e, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f4729287700, createdName=bnurmamat, createdTime=Fri May 31 08:51:00 CST 2019, time=2019-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1650743, encodeId=d72a1650e4304, content=<a href='/topic/show?id=ffae4e614b6' target=_blank style='color:#2F92EE;'>#局部晚期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47614, encryptionId=ffae4e614b6, topicName=局部晚期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=901d24099859, createdName=yhy100208, createdTime=Sat Feb 16 20:51:00 CST 2019, time=2019-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333083, encodeId=a175133308372, content=<a href='/topic/show?id=4339101926f4' target=_blank style='color:#2F92EE;'>#骨骼肌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101926, encryptionId=4339101926f4, topicName=骨骼肌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIuNQXObUwZmFG3VcZa2uhFq27sY7vfTowUhQCgRj2bj1odUibMF4sFXpuRLf6IE5t5yGVDSiaOoOcQ/132, createdBy=1e622500088, createdName=ms1065684921169360, createdTime=Thu Nov 01 00:51:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405869, encodeId=c247140586969, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Thu Nov 01 00:51:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1408150, encodeId=49301408150c7, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Thu Nov 01 00:51:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616411, encodeId=2f0b1616411d0, content=<a href='/topic/show?id=8a0f59823b2' target=_blank style='color:#2F92EE;'>#晚期宫颈癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59823, encryptionId=8a0f59823b2, topicName=晚期宫颈癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a7b19750456, createdName=ms7258648636991762, createdTime=Thu Nov 01 00:51:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350945, encodeId=8a25350945fc, content=认真学习,不断进步,把经验分享给同好。点赞了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Tue Oct 30 11:52:37 CST 2018, time=2018-10-30, status=1, ipAttribution=)]
    2018-11-01 一闲
  6. [GetPortalCommentsPageByObjectIdResponse(id=1692017, encodeId=6a3e169201e0e, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f4729287700, createdName=bnurmamat, createdTime=Fri May 31 08:51:00 CST 2019, time=2019-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1650743, encodeId=d72a1650e4304, content=<a href='/topic/show?id=ffae4e614b6' target=_blank style='color:#2F92EE;'>#局部晚期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47614, encryptionId=ffae4e614b6, topicName=局部晚期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=901d24099859, createdName=yhy100208, createdTime=Sat Feb 16 20:51:00 CST 2019, time=2019-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333083, encodeId=a175133308372, content=<a href='/topic/show?id=4339101926f4' target=_blank style='color:#2F92EE;'>#骨骼肌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101926, encryptionId=4339101926f4, topicName=骨骼肌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIuNQXObUwZmFG3VcZa2uhFq27sY7vfTowUhQCgRj2bj1odUibMF4sFXpuRLf6IE5t5yGVDSiaOoOcQ/132, createdBy=1e622500088, createdName=ms1065684921169360, createdTime=Thu Nov 01 00:51:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405869, encodeId=c247140586969, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Thu Nov 01 00:51:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1408150, encodeId=49301408150c7, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Thu Nov 01 00:51:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616411, encodeId=2f0b1616411d0, content=<a href='/topic/show?id=8a0f59823b2' target=_blank style='color:#2F92EE;'>#晚期宫颈癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59823, encryptionId=8a0f59823b2, topicName=晚期宫颈癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a7b19750456, createdName=ms7258648636991762, createdTime=Thu Nov 01 00:51:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350945, encodeId=8a25350945fc, content=认真学习,不断进步,把经验分享给同好。点赞了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Tue Oct 30 11:52:37 CST 2018, time=2018-10-30, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1692017, encodeId=6a3e169201e0e, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f4729287700, createdName=bnurmamat, createdTime=Fri May 31 08:51:00 CST 2019, time=2019-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1650743, encodeId=d72a1650e4304, content=<a href='/topic/show?id=ffae4e614b6' target=_blank style='color:#2F92EE;'>#局部晚期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47614, encryptionId=ffae4e614b6, topicName=局部晚期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=901d24099859, createdName=yhy100208, createdTime=Sat Feb 16 20:51:00 CST 2019, time=2019-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333083, encodeId=a175133308372, content=<a href='/topic/show?id=4339101926f4' target=_blank style='color:#2F92EE;'>#骨骼肌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101926, encryptionId=4339101926f4, topicName=骨骼肌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIuNQXObUwZmFG3VcZa2uhFq27sY7vfTowUhQCgRj2bj1odUibMF4sFXpuRLf6IE5t5yGVDSiaOoOcQ/132, createdBy=1e622500088, createdName=ms1065684921169360, createdTime=Thu Nov 01 00:51:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405869, encodeId=c247140586969, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Thu Nov 01 00:51:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1408150, encodeId=49301408150c7, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Thu Nov 01 00:51:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616411, encodeId=2f0b1616411d0, content=<a href='/topic/show?id=8a0f59823b2' target=_blank style='color:#2F92EE;'>#晚期宫颈癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59823, encryptionId=8a0f59823b2, topicName=晚期宫颈癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a7b19750456, createdName=ms7258648636991762, createdTime=Thu Nov 01 00:51:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350945, encodeId=8a25350945fc, content=认真学习,不断进步,把经验分享给同好。点赞了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Tue Oct 30 11:52:37 CST 2018, time=2018-10-30, status=1, ipAttribution=)]
    2018-10-30 lietome24

    认真学习,不断进步,把经验分享给同好。点赞了!

    0

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