Chest :肥胖与肺病有何联系呢?

2017-07-23 MedSci MedSci原创

在过去的30年里,全球范围内的肥胖患病率迅速增加。世界正面临着前所未有的肥胖流行病,发达国家发病率最高。超过三分之一的美国成年人肥胖,而另外三分之一的人超重。更令人担忧的是,32%的美国儿童和青少年要么超重,要么肥胖。这导致许多常见疾病的发病机制和临床表现发生了重要变化。近日,在医学杂志Lancet上面发表了一篇文章,研究人员旨在探讨肥胖与肺部疾病之间的关系。

在过去的30年里,全球范围内的肥胖患病率迅速增加。世界正面临着前所未有的肥胖流行病,发达国家发病率最高。超过三分之一的美国成年人肥胖,而另外三分之一的人超重。更令人担忧的是,32%的美国儿童和青少年要么超重,要么肥胖。这导致许多常见疾病的发病机制和临床表现发生了重要变化。近日,在医学杂志Lancet上面发表了一篇文章,研究人员旨在探讨肥胖与肺部疾病之间的关系,强调了一些主要的发现,这些发现促进了我们对肥胖的机制的理解,以及它与常见的肺部疾病的代谢紊乱有关。与脂肪含量相关的肺功能的改变很重要,但肥胖不仅仅是质量负荷状态,而且身体质量指数(BMI)只是机体代谢指标的间接测量。肥胖状态与肠道菌群、细胞代谢、脂质处理、免疫功能、胰岛素抵抗和脂肪组织产生的循环因子有关。这些因素综合起来,可以从根本上改变肺部健康和疾病的发病机制和病理生理学。肥胖是导致多种呼吸道疾病发展的主要危险因素,如哮喘、肺动脉高血压、睡眠呼吸暂停、肥胖性肺通气不足、肺炎、急性呼吸窘迫综合征(ARDS)等,肥胖也使慢性阻塞性肺病(COPD)等疾病的发病机制复杂化。这是因为肥胖会通过质量负荷、激素、代谢、炎症、神经和饮食等因素的

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    2018-04-14 Smile2680
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    2018-04-01 amy0559
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    2017-07-24 186****0580(小山羊)

    学习了谢谢了。

    0

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