ICAAC 2015:肺炎链球菌是引起儿童重症肺炎的首要致病菌

2015-09-24 sunshine 译 MedSci原创

ICAAC 2015:肺炎链球菌是引起儿童重症肺炎的首要致病菌据ICAAC 2015给出的数据显示,发展中国家儿童重症肺炎最常见的病因是由于肺炎链球菌、人偏肺病毒、呼吸道合胞病毒以及甲型流感病毒的感染。“肺炎是儿童致死的首要原因;但是,对发展中国家儿童肺炎的病因却知之甚少,” Thomas Bénet博士在新闻发布会上说道,“一项在三大洲进行的流行病学研究显示,近一半5岁以下的儿童肺炎患者为肺炎链

据ICAAC 2015给出的数据显示,发展中国家儿童重症肺炎最常见的病因是由于肺炎链球菌、人偏肺病毒、呼吸道合胞病毒以及甲型流感病毒的感染。

“肺炎是儿童致死的首要原因;但是,对发展中国家儿童肺炎的病因却知之甚少,” Thomas Bénet博士在新闻发布会上说道,“一项在三大洲进行的流行病学研究显示,近一半的5岁以下的儿童肺炎患者为肺炎链球菌感染所致。”

研究人员分析了2011年7月年及2012年10月在马里一家医院住院的儿童患者。将其分为两组:A组,年龄小于5岁,已确诊为肺炎(n=118);B组,住院患儿无呼吸道症状(n=98)。采集所有患者的呼吸道样本,以确定儿童肺炎的病毒及细菌类型。


患者入院时的症状及临床体征各不相同,但是与病史的人口统计学数据并不相关。使用多变量分析后,Bénet及其同事表示,重症肺炎最常见的病因为肺炎链球菌感染(校正后OR= 3.4;95% CI,1.6-7),偏肺病毒(aOR = 17.2; 95% CI, 2-151.4),呼吸道合胞病毒(aOR = 7.4;95% CI,2.3-23.3),甲型流感病毒(aOR = 10.7;95% CI,1-112.2)。总而言之,研究人员表示,41.6%的肺炎患者(95% CI,35.1%-47.4%)是由肺炎链球菌感染所致。

Bénet说道,“提高肺炎链球菌的疫苗接种覆盖率并研发出呼吸道合胞病毒的疫苗可大大降低发展中国家的医疗负担。”

原始出处:
Bénet T, et al. Etiology and Factors Associated with Severe Pneumonia Among Children Under 5 Years of Age in Mali: A Case-control Pilot Study. Presented at: Interscience Conference on Antimicrobial Agents and Chemotherapy; Sept. 17-21, 2015; San Diego.

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    2015-09-27 lovejing

    厉害啊

    0

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    2015-09-26 huangdf
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    2015-09-26 cooco

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