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EUR HEART J ：研究显示肠道微生物代谢产物三甲胺-N-氧化物与心血管风险有关！

2017-07-26 MedSci MedSci原创

三甲胺-N-氧化物(TMAO)微生物菌群心血管风险Meta分析
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肠道微生物代谢产物三甲胺-N-氧化物(TMAO)成为一种新型的增加心血管风险的潜在重要原因。近日，在医学权威杂志EUR HEART J上面发表了一篇研究文章，研究人员运用系统回顾和meta分析方法系统地估计和量化TMAO血浆水平、死亡率和主要的心脑血管不良事件(MACCE)之间的联系。

肠道微生物代谢产物三甲胺-N-氧化物(TMAO)成为一种新型的增加心血管风险的潜在重要原因。近日，在医学权威杂志EUR HEART J上面发表了一篇研究文章，研究人员运用系统回顾和meta分析方法系统地估计和量化TMAO血浆水平、死亡率和主要的心脑血管不良事件(MACCE)之间的联系。

研究人员在MEDLINE、ISI科学网和SCOPUS数据库搜索截止到2017年4月出版的研究，并且系统地讨论了TMAO血浆水平、全因死亡率和MACCE之间的联系。主要结果为全因死亡率；次要结果为MACCE。这项综合分析共包括17项临床研究，26167名受试者。研究人群的随访时间的平均值为4.3±1.5年。

结果显示：高TMAO血浆水平与全因死亡率（基于15662名受试者的16个队列的14项研究，危险比(HR)：1.91；95%置信区间(CI)：1.40-2.61，P<0.0001，I2=94%）和MACCE（基于13944名受试者的6个队列的5项研究，HR：1.67，95% CI：1.33-2.11，P<0.00001，I2=46%）的增高相关。剂量反应meta分析表明：全因死亡率的相对危险度(RR)增加了7.6% / 10μmol/L的TMAO增量[RR：1.07，95%可信区间：1.04-1.11，P<0.0001；基于7项研究)。TMAO和死亡率的关联在所有被检查的子组和所有受试人群中持续存在。

由此可见，TMAO血浆水平与心血管风险和死亡率增加之间存在阳性剂量依赖关系。

原始出处：

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    2017-09-21 guguangxiang

    #生物代谢#

    0

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    2018-02-01 wjcjjian

    #微生物#

    0

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    2017-10-29 jyzxjiangqin

    肠道微生物代谢产物.

    0

  4. 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objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Aug 19 10:17:02 CST 2017, time=2017-08-19, status=1, ipAttribution=)]
    2017-10-18 jyzxjiangqin

    肠道微生物代谢.

    0

  5. 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    2017-10-03 jyzxjiangqin

    研究显示肠道微生物.

    0

  6. 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    2017-09-10 ms5353107019656438

    #血管风险#

    0

  7. 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objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Aug 19 10:17:02 CST 2017, time=2017-08-19, status=1, ipAttribution=)]
    2017-09-21 jyzxjiangqin

    肠道微生物的益处.

    0

  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89812, encryptionId=56658981223, topicName=血管风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Sun Sep 10 18:44:00 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246244, encodeId=3a7f24624431, content=肠道微生物的益处., beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Thu Sep 21 07:19:31 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243498, encodeId=fa7324349881, content=肠道微生物代谢产物., beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Sep 13 07:45:12 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238549, encodeId=0cbe23854953, content=肠道微生物的应用., beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Aug 30 07:18:56 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235058, encodeId=f282235058e2, content=研究显示肠道微生物。, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Aug 19 10:17:02 CST 2017, time=2017-08-19, status=1, ipAttribution=)]
    2017-09-13 jyzxjiangqin

    肠道微生物代谢产物.

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1798407, encodeId=f8ce1e9840766, content=<a href='/topic/show?id=08276918eab' target=_blank style='color:#2F92EE;'>#生物代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69187, encryptionId=08276918eab, topicName=生物代谢)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/iaP1mV9qBwx5tE2F4xcG1r4x1PibWvluIFLB8VsViakqNMBia2Z0wFibVrYwDEILvHB1OomzzTAAGy5MVl5BrdEv9Bw/132, createdBy=e11f100, createdName=guguangxiang, createdTime=Thu Sep 21 21:44:00 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1824803, encodeId=85481824803b6, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, 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objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Sep 13 07:45:12 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238549, encodeId=0cbe23854953, content=肠道微生物的应用., beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Aug 30 07:18:56 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235058, encodeId=f282235058e2, content=研究显示肠道微生物。, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Aug 19 10:17:02 CST 2017, time=2017-08-19, status=1, ipAttribution=)]
    2017-08-30 jyzxjiangqin

    肠道微生物的应用.

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1798407, encodeId=f8ce1e9840766, content=<a href='/topic/show?id=08276918eab' target=_blank style='color:#2F92EE;'>#生物代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69187, encryptionId=08276918eab, topicName=生物代谢)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/iaP1mV9qBwx5tE2F4xcG1r4x1PibWvluIFLB8VsViakqNMBia2Z0wFibVrYwDEILvHB1OomzzTAAGy5MVl5BrdEv9Bw/132, createdBy=e11f100, createdName=guguangxiang, createdTime=Thu Sep 21 21:44:00 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1824803, encodeId=85481824803b6, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, 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objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Sep 13 07:45:12 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238549, encodeId=0cbe23854953, content=肠道微生物的应用., beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Aug 30 07:18:56 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235058, encodeId=f282235058e2, content=研究显示肠道微生物。, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Aug 19 10:17:02 CST 2017, time=2017-08-19, status=1, ipAttribution=)]
    2017-08-19 jyzxjiangqin

    研究显示肠道微生物。

    0

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