Scientific Reports:干李子可预防辐射导致的骨质流失

2016-02-28 sunshine编译 MedSci原创

据发表于Scientific Reports的一项新的研究表明,干李子或可防止辐射所致的骨质丧失。 对于接受放疗的癌症患者、宇航员、核工作者以及核事故受害者来说,此研究发现具有重要意义。

据发表于Scientific Reports的一项新的研究表明,干李子或可防止辐射所致的骨质丧失。

对于接受放疗的癌症患者、宇航员、核工作者以及核事故受害者来说,此研究发现具有重要意义。

该研究作者Dr. Nancy Turner解释道,电离辐射会引起骨重塑,可能会破坏骨骼的完整性,致使骨骼脆弱。

骨质的流失可导致骨质疏松症的发生,骨头变得脆弱,易碎,更容易破坏。据估计,全球每年有890万例因骨折疏松症而发生的骨折。

该研究中,研究人员着手探究了促进电离辐射相关的骨损伤的机制,如辐射引起的氧化应激。

干李子可减少与骨破坏相关的基因的表达

研究人员在暴露于辐射中的小鼠身上测试了一些不同的抗氧化剂和抗炎药,评估这些干预措施对骨破坏相关的基因的表达的影响,以及对骨质流失的影响。

这些干预措施包括包含五种不同抗氧化剂的混合疗法(抗坏血酸、N-乙酰半胱氨酸、L-硒代蛋氨酸,氨基酸和维生素E)、硫辛酸、布洛芬和干李子。

结果发现,干李子在降低Nfe2l2, Rankl, Mcp1, Opg 及 TNF-α基因表达的作用上效果最强,这些基因均与骨破坏有关。干李子还是防止电离辐射所致的骨质损失最有效的。

虽然研究人员也无法解释干李子防护电离辐射所致骨质损失的确切机制,但是,他们指出干李子中含有大量的多酚,包括没食子酸、咖啡酰奎宁酸、香豆酸、芦丁,多酚具有抗氧化和抗炎的特性。

最后,Dr. Turner说道,“干李子中含有生物活性成分,可为放疗或长时间太空暴露辐射所破坏的骨骼的完整性提供有效的干预。从这项研究中,我们可以看出,含有干李子的饮食或可防止放射暴露(地面或太空)所致的骨损伤。”

原始出处:

Honor Whiteman. Dried plums could protect against radiation-induced bone loss. MNT, 26 Feb 2016.

Nancy Turner et al., Dried plum diet protects from bone loss caused by ionizing radiation, Scientific Reports, doi: 10.1038/srep21343, published online 11 February 2016.

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    2016-03-01 破风4392

    get

    0

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    2016-03-01 jiyangfei
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    2016-03-01 jichang
  5. [GetPortalCommentsPageByObjectIdResponse(id=1949192, encodeId=103e1949192d5, content=<a href='/topic/show?id=ff7c10186004' target=_blank style='color:#2F92EE;'>#骨质流失#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101860, encryptionId=ff7c10186004, topicName=骨质流失)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Wed Oct 19 20:33:00 CST 2016, time=2016-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66561, encodeId=590d66561e3, content=get, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160301/IMG56D53216887587291.jpg, createdBy=3c131694128, createdName=破风4392, createdTime=Tue Mar 01 15:05:00 CST 2016, time=2016-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349315, encodeId=a08913493159f, content=<a href='/topic/show?id=838593e35b2' target=_blank style='color:#2F92EE;'>#辐射#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93735, encryptionId=838593e35b2, topicName=辐射)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8e4c53, createdName=jiyangfei, createdTime=Tue Mar 01 01:33:00 CST 2016, time=2016-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375179, encodeId=ad2a13e5179ad, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Tue Mar 01 01:33:00 CST 2016, time=2016-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592307, encodeId=f87e159230e82, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Tue Mar 01 01:33:00 CST 2016, time=2016-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66368, encodeId=fa7766368f9, content=放疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Mon Feb 29 23:20:00 CST 2016, time=2016-02-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66352, encodeId=3eed66352e5, content=这个给放疗的人挺有用啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib260FNcic8ThYZTmbW36JHpvHcnIog7VbWIQjibo1kwuH9obXRJJtqHn1hYHHLG0DpIMIBVFPhBBpQOJWDk1rbib2Y/0, createdBy=d27274268, createdName=sillywu, createdTime=Mon Feb 29 21:06:00 CST 2016, time=2016-02-29, status=1, ipAttribution=)]
    2016-03-01 Eleven17
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    2016-02-29 xiaotaiyang1

    放疗

    0

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    2016-02-29 sillywu

    这个给放疗的人挺有用啊

    0

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