J Periodontal Res:naswardippers的牙周参数及胶原降解生物标志物的释放

2018-04-05 MedSci MedSci原创

本研究的目的是比较naswar(NW)和non-naswar(对照组)的临床牙周参数和牙龈胶原蛋白的C-端肽吡啶啉交联(ICTP)和C端交联端肽(CTX)控制)释放。

本研究的目的是比较naswar(NW)和non-naswar(对照组)的临床牙周参数和牙龈胶原蛋白的C-端肽吡啶啉交联(ICTP)和C端交联端肽(CTX)释放。

实验纳入87名个体(42名NW和45名对照)。在NW和对照组之间比较临床(菌斑指数,探查出血,探诊深度和临床附着丧失)和影像学(边缘骨吸收)牙周参数。取NW和对照组受试者的龈标本,评估ICTP和CTX水平(使用ELISA)并使用微拉曼光谱分析。使用Kruskal-Wallis和Mann-Whitney U检验评估组间牙周参数差异的显着性。使用配对t检验来比较所有组的暴露时间的干质量损失百分比和ICTP和CTX的释放速率,以检查暴露时间的影响。

结果:NW组的临床和影像学牙周参数显着高于对照组(P <0.01)。在拉曼光谱中,NW组中最强和最锐的频带出现在1260cm-1处。在Amide I的拉曼频带观察到波数略有变化。 NW组患者的ICTP和CTX释放率显着高于对照组(P <0.05)。组类型和时间均ICTP和CTX的释放有显着影响(P <0.05)。

结论: NW组受试者的临床和放射学牙周参数差于对照组。由于使用NW,NW组受试者结缔组织中的胶原蛋白分解程度更高。

原始出处:

U. Daood, et al. Clinical and radiographic periodontal parameters and release of collagen degradation biomarkers in naswardippers. Journal of Periodontal Research. 2018 February. doi:10.1111/jre.12496

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    2018-08-27 一叶知秋
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    2018-04-06 feather89
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    2018-04-06 lietome2

    认真学习.不断进步.把经验分享给同好.点赞了!

    0