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JAHA：高水平的sIL-6R与STEMI患者未来心血管事件和死亡率相关

2016-07-25 phylis 译 MedSci原创

sIL-6R心肌梗死心血管事件死亡率
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背景：ST段抬高型心肌梗死（STEMI）患者可溶性白细胞介素-6（IL-6）受体（sIL-6R）和糖蛋白130（sgp130）的报道较少，包括一小部分患者。本研究的目的是探讨急性期STEMI这些生物标志物水平与未来心血管事件可能存在的相关性。方法和结果：2007-2011期间，检测了989例STEMI患者循环中IL-6、sgp130、sIL-6R，和C-反应蛋白（CRP），并且在随访期间，记录心血

背景：ST段抬高型心肌梗死（STEMI）患者可溶性白细胞介素-6（IL-6）受体（sIL-6R）和糖蛋白130（sgp130）的报道较少，包括一小部分患者。本研究的目的是探讨急性期STEMI这些生物标志物水平与未来心血管事件可能存在的相关性。

方法和结果：2007-2011期间，检测了989例STEMI患者循环中IL-6、sgp130、sIL-6R，和C-反应蛋白（CRP），并且在随访期间，记录心血管事件的发生。主要终点是全因死亡、心肌梗死、脑卒中、非血运重建复合，或心力衰竭再入院的组合。采用Cox回归模型估计为生物标志物的水平与心血管事件相关的危险比（HR）。症状开始后24h内sIL-6R，sgp130，IL-6和CRP中位数分别为39.2ng/mL，240ng/mL，18.8ng/mL，13.7ng/mL。平均随访时间为4.6年，200例（20.2%）发生主要预后，82例（8.3%）死亡。与低水平的sIL-6R相比，sIL-6R水平在上四分位数的患者（＞47.7 ng/mL）未来不良事件的风险（主要终点）和死亡率显著增高（校正HR分别为，1.54 [ 1.08，2.21 ]；和1.81 [ 1.04，3.18 ]；）。IL-6和sgp130水平与未来事件都不相关，但CRP水平在上四分位数（> 31.5mg/L）的患者死亡风险更高。

结论：高水平的sIL-6R与STEMI患者未来心血管事件和死亡率相关，提示IL-6信号转导系统的重要作用。


原始出处：

Ritschel VN, Seljeflot I, et al. Circulating Levels of IL-6 Receptor and gp130 and Long-Term Clinical Outcomes in ST-Elevation Myocardial Infarction. J Am Heart Assoc. 2016 Jun 13.

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    2016-12-03 12498c32m68暂无昵称

    #STEMI患者#

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    2017-01-14 lxg951

    #sIL-6R#

    0

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    2017-03-08 hukaixun

    #血管事件#

    0

  4. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481925, encodeId=e4c4148192552, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Wed Jul 27 13:45:00 CST 2016, time=2016-07-27, status=1, ipAttribution=)]
    2016-10-11 ylzr123

    好文值得点赞！继续关注学习。

    0

  5. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481925, encodeId=e4c4148192552, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Wed Jul 27 13:45:00 CST 2016, time=2016-07-27, status=1, ipAttribution=)]
    2016-09-25 1e10c84am36(暂无匿称)

    文章很好值得关注

    0

  6. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481925, encodeId=e4c4148192552, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Wed Jul 27 13:45:00 CST 2016, time=2016-07-27, status=1, ipAttribution=)]
    2016-08-05 午夜星河

    好好学习

    0

  7. 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href='/topic/show?id=fae896e7ea' target=_blank style='color:#2F92EE;'>#IL-6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9677, encryptionId=fae896e7ea, topicName=IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f984116, createdName=kzlchina, createdTime=Wed Jul 27 13:45:00 CST 2016, time=2016-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349850, encodeId=5e681349850bf, content=<a href='/topic/show?id=6c5796e898' target=_blank style='color:#2F92EE;'>#IL-6R#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9678, encryptionId=6c5796e898, topicName=IL-6R)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Wed Jul 27 13:45:00 CST 2016, time=2016-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481925, encodeId=e4c4148192552, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Wed Jul 27 13:45:00 CST 2016, time=2016-07-27, status=1, ipAttribution=)]
    2016-07-27 zhaohui6731

    #AHA#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1936701, encodeId=f1791936e01b0, content=<a href='/topic/show?id=74bd16e850c' target=_blank style='color:#2F92EE;'>#STEMI患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16785, encryptionId=74bd16e850c, topicName=STEMI患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, createdName=12498c32m68暂无昵称, createdTime=Sat Dec 03 00:45:00 CST 2016, time=2016-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1794092, encodeId=779c1e94092be, content=<a href='/topic/show?id=d09b16315ec' target=_blank style='color:#2F92EE;'>#sIL-6R#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16315, encryptionId=d09b16315ec, topicName=sIL-6R)], attachment=null, authenticateStatus=null, createdAvatar=, 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200609/ef6a57dbe7f1489dad7446b7c5217858/d5e4fe65996c4446a029b0f5d056abb1.jpg, createdBy=6b011518214, createdName=午夜星河, createdTime=Fri Aug 05 20:51:00 CST 2016, time=2016-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267314, encodeId=c636126e314c7, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Jul 27 13:45:00 CST 2016, time=2016-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273756, encodeId=74cd12e375633, content=<a href='/topic/show?id=fae896e7ea' target=_blank style='color:#2F92EE;'>#IL-6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9677, encryptionId=fae896e7ea, topicName=IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f984116, createdName=kzlchina, createdTime=Wed Jul 27 13:45:00 CST 2016, time=2016-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349850, encodeId=5e681349850bf, content=<a href='/topic/show?id=6c5796e898' target=_blank style='color:#2F92EE;'>#IL-6R#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9678, encryptionId=6c5796e898, topicName=IL-6R)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Wed Jul 27 13:45:00 CST 2016, time=2016-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481925, encodeId=e4c4148192552, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Wed Jul 27 13:45:00 CST 2016, time=2016-07-27, status=1, ipAttribution=)]
    2016-07-27 kzlchina

    #IL-6#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1936701, encodeId=f1791936e01b0, content=<a href='/topic/show?id=74bd16e850c' target=_blank style='color:#2F92EE;'>#STEMI患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16785, encryptionId=74bd16e850c, topicName=STEMI患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, createdName=12498c32m68暂无昵称, createdTime=Sat Dec 03 00:45:00 CST 2016, time=2016-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1794092, encodeId=779c1e94092be, content=<a href='/topic/show?id=d09b16315ec' target=_blank style='color:#2F92EE;'>#sIL-6R#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16315, encryptionId=d09b16315ec, topicName=sIL-6R)], attachment=null, authenticateStatus=null, createdAvatar=, 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200609/ef6a57dbe7f1489dad7446b7c5217858/d5e4fe65996c4446a029b0f5d056abb1.jpg, createdBy=6b011518214, createdName=午夜星河, createdTime=Fri Aug 05 20:51:00 CST 2016, time=2016-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267314, encodeId=c636126e314c7, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Jul 27 13:45:00 CST 2016, time=2016-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273756, encodeId=74cd12e375633, content=<a href='/topic/show?id=fae896e7ea' target=_blank style='color:#2F92EE;'>#IL-6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9677, encryptionId=fae896e7ea, topicName=IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f984116, createdName=kzlchina, createdTime=Wed Jul 27 13:45:00 CST 2016, time=2016-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349850, encodeId=5e681349850bf, content=<a href='/topic/show?id=6c5796e898' target=_blank style='color:#2F92EE;'>#IL-6R#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9678, encryptionId=6c5796e898, topicName=IL-6R)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Wed Jul 27 13:45:00 CST 2016, time=2016-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481925, encodeId=e4c4148192552, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Wed Jul 27 13:45:00 CST 2016, time=2016-07-27, status=1, ipAttribution=)]
    2016-07-27 jklm09

    #IL-6R#

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1936701, encodeId=f1791936e01b0, content=<a href='/topic/show?id=74bd16e850c' target=_blank style='color:#2F92EE;'>#STEMI患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16785, encryptionId=74bd16e850c, topicName=STEMI患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, createdName=12498c32m68暂无昵称, createdTime=Sat Dec 03 00:45:00 CST 2016, time=2016-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1794092, encodeId=779c1e94092be, content=<a href='/topic/show?id=d09b16315ec' target=_blank style='color:#2F92EE;'>#sIL-6R#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16315, encryptionId=d09b16315ec, topicName=sIL-6R)], attachment=null, authenticateStatus=null, createdAvatar=, 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:16:06 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135086, encodeId=ef0013508686, content=文章很好值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 25 17:17:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96173, encodeId=0c51961e351, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200609/ef6a57dbe7f1489dad7446b7c5217858/d5e4fe65996c4446a029b0f5d056abb1.jpg, createdBy=6b011518214, createdName=午夜星河, createdTime=Fri Aug 05 20:51:00 CST 2016, time=2016-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267314, encodeId=c636126e314c7, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Jul 27 13:45:00 CST 2016, time=2016-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273756, encodeId=74cd12e375633, content=<a href='/topic/show?id=fae896e7ea' target=_blank style='color:#2F92EE;'>#IL-6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9677, encryptionId=fae896e7ea, topicName=IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f984116, createdName=kzlchina, createdTime=Wed Jul 27 13:45:00 CST 2016, time=2016-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349850, encodeId=5e681349850bf, content=<a href='/topic/show?id=6c5796e898' target=_blank style='color:#2F92EE;'>#IL-6R#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9678, encryptionId=6c5796e898, topicName=IL-6R)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Wed Jul 27 13:45:00 CST 2016, time=2016-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481925, encodeId=e4c4148192552, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Wed Jul 27 13:45:00 CST 2016, time=2016-07-27, status=1, ipAttribution=)]
    2016-07-27 12498bb3m92(暂无昵称)

    #STEM#

    0

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