PLOS ONE:重症监护病房患者谵妄期间的葡萄糖变异性:一项前瞻性队列研究

2018-11-17 海北 MedSci原创

最近,研究人员进行了一项前瞻性队列研究,来探究在重症监护病房(ICU)中,糖尿病和非糖尿病的重症患者谵妄期间葡萄糖变异性与非谵妄期间相比是否有所改变。

最近,研究人员进行了一项前瞻性队列研究,来探究在重症监护病房(ICU)中,糖尿病和非糖尿病的重症患者谵妄期间葡萄糖变异性与非谵妄期间相比是否有所改变。

在这项20111月至20136月期间进行的前瞻性队列研究中,包括了在ICU住院期间患有谵妄和非谵妄的重症患者。研究人员使用各种定义(平均葡萄糖,标准偏差,平均绝对葡萄糖,每日血糖差,以及低血糖和高血糖发生的变化)在每个观察日测量葡萄糖变异性。混合效应模型和具有logit链接功能的广义混合效应模型被用于研究谵妄和葡萄糖变异之间的关联,调整潜在的混杂因素。

除了低血糖的风险之外,使用该估计的各种定义,研究人员发现,谵妄与较高的葡萄糖变异性无关。对于低血糖,研究人员确实发现与糖尿病患者的谵妄有关(OR = 2.78; 95CI1.71-6.32p = 0.005),但非糖尿病患者中没有类似的关联(OR adj.1.16; 95CI 0.58-2.28p = 0.689)。

尽管危重患者的谵妄和低血糖之间存在正相关关系,但谵妄与更明显的葡萄糖变异性无关。该研究结果表明,在ICU谵妄期间,糖尿病患者应更密切地监测血糖水平,以预防低血糖。


原始出处:

van Keulen K et al. Glucose variability during delirium in diabetic and non-diabetic intensive care unit patients- A prospective cohort study. PLOS ONE, 2018; doi: 10.1371/journal.pone.0205637. eCollection 2018.


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    2018-11-19 bioon6

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