Cell Physiol Biochem:IL-8通过CXCR2介导的PI3k/Akt信号通路增强BMSCs的骨再生作用

2018-07-19 MedSci MedSci原创

使用骨髓间充质干细胞(BMSCs)进行组织工程骨移植是治疗大量骨丧失的有效技术,而骨再生过程的分子调节仍然知之甚少。本研究旨在评估白细胞介素-8(IL-8)在BMSCs募集宿主细胞和骨再生中的作用。进行transwell测定以检查IL-8/CXCR1/CXCR2/PI3k/Akt对hBMSsC的迁移潜力的作用。通过检查2种软骨形成标志物Sox9和2型胶原(COL2)来评估hBMSCs的体外软骨形成

使用骨髓间充质干细胞(BMSCs)进行组织工程骨移植是治疗大量骨丧失的有效技术,而骨再生过程的分子调节仍然知之甚少。本研究旨在评估白细胞介素-8(IL-8)在BMSCs募集宿主细胞和骨再生中的作用。

进行transwell测定以检查IL-8/CXCR1/CXCR2/PI3k/Akt对hBMSsC的迁移潜力的作用。通过检查2种软骨形成标志物Sox9和2型胶原(COL2)来评估hBMSCs的体外软骨形成分化。将有/无IL-8的mBMSC用于组织工程骨(TEB)植入骨缺损区域,同时使用CXCR2或Akt抑制剂。评估再生骨的密度和Masson染色。通过RT-qPCR和免疫组织化学测量相关蛋白、Sox9和COL2的表达水平来评估软骨形成。

结果显示,IL-8可通过CXCR2介导的PI3k/Akt信号传导通路诱导hBMSCs的体外迁移。 IL-8增强小鼠TEB植入骨缺损中的骨生成。IL-8在体外和体内通过CXCR2介导的PI3k/Akt信号传导通路诱导hBMSCs的软骨形成分化。

综上所述,该研究结果表明,IL-8通过CXCR2介导的PI3k/Akt信号传导通路增强MSCs的骨再生作用。

原始出处:


Yang A, Lu Y, et al., IL-8 Enhances Therapeutic Effects of BMSCs on Bone Regeneration via CXCR2-Mediated PI3k/Akt Signaling Pathway. Cell Physiol Biochem. 2018 Jul 17;48(1):361-370. doi: 10.1159/000491742.

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    2019-04-07 维他命
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    2018-12-28 xfpan20
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encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Nov 15 10:04:00 CST 2018, time=2018-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2024147, encodeId=8c3a202414e85, content=<a href='/topic/show?id=bbba14239f5' target=_blank style='color:#2F92EE;'>#PI3K/AKT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14239, encryptionId=bbba14239f5, topicName=PI3K/AKT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Mon Mar 04 11:04:00 CST 2019, time=2019-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918202, encodeId=8624191820280, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Dec 16 15:04:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2069240, encodeId=a0f0206924016, content=<a href='/topic/show?id=7a7135902d' target=_blank style='color:#2F92EE;'>#BMSC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3590, encryptionId=7a7135902d, topicName=BMSC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=909c71, createdName=shijzhiewnjhch, createdTime=Wed May 29 04:04:00 CST 2019, time=2019-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789038, encodeId=56361e89038ea, content=<a href='/topic/show?id=e05d14241ae' target=_blank style='color:#2F92EE;'>#PI3K/Akt信号#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14241, encryptionId=e05d14241ae, topicName=PI3K/Akt信号)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80ca273, createdName=fanweitanzhen, createdTime=Sun May 19 06:04:00 CST 2019, time=2019-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625997, encodeId=1c78162599e4e, content=<a href='/topic/show?id=cb38968469' target=_blank style='color:#2F92EE;'>#IL-8#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9684, encryptionId=cb38968469, topicName=IL-8)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31920946979, createdName=respect, createdTime=Sat Jul 21 05:04:00 CST 2018, time=2018-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625916, encodeId=c47a162591621, content=<a href='/topic/show?id=7435122e3c3' target=_blank style='color:#2F92EE;'>#MSCs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12273, encryptionId=7435122e3c3, topicName=MSCs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=18ac20929511, createdName=zhanfl, createdTime=Sat Jul 21 05:04:00 CST 2018, time=2018-07-21, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1788853, encodeId=be491e8885354, content=<a href='/topic/show?id=866d1421e4c' target=_blank style='color:#2F92EE;'>#Physio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14217, encryptionId=866d1421e4c, topicName=Physio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Sep 29 20:04:00 CST 2018, time=2018-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961020, encodeId=69b519610204c, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sun Apr 07 20:04:00 CST 2019, time=2019-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1656168, encodeId=a6571656168f0, content=<a href='/topic/show?id=f4782246ec' target=_blank style='color:#2F92EE;'>#Akt#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2246, encryptionId=f4782246ec, topicName=Akt)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8c724776724, createdName=xfpan20, createdTime=Fri Dec 28 05:04:00 CST 2018, time=2018-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870751, encodeId=aaf518e0751d8, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Nov 15 10:04:00 CST 2018, time=2018-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2024147, encodeId=8c3a202414e85, content=<a href='/topic/show?id=bbba14239f5' target=_blank style='color:#2F92EE;'>#PI3K/AKT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14239, encryptionId=bbba14239f5, topicName=PI3K/AKT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Mon Mar 04 11:04:00 CST 2019, time=2019-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918202, encodeId=8624191820280, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Dec 16 15:04:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2069240, encodeId=a0f0206924016, content=<a href='/topic/show?id=7a7135902d' target=_blank style='color:#2F92EE;'>#BMSC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3590, encryptionId=7a7135902d, topicName=BMSC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=909c71, createdName=shijzhiewnjhch, createdTime=Wed May 29 04:04:00 CST 2019, time=2019-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789038, encodeId=56361e89038ea, content=<a href='/topic/show?id=e05d14241ae' target=_blank style='color:#2F92EE;'>#PI3K/Akt信号#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14241, encryptionId=e05d14241ae, topicName=PI3K/Akt信号)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80ca273, createdName=fanweitanzhen, createdTime=Sun May 19 06:04:00 CST 2019, time=2019-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625997, encodeId=1c78162599e4e, content=<a href='/topic/show?id=cb38968469' target=_blank style='color:#2F92EE;'>#IL-8#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9684, encryptionId=cb38968469, topicName=IL-8)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31920946979, createdName=respect, createdTime=Sat Jul 21 05:04:00 CST 2018, time=2018-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625916, encodeId=c47a162591621, content=<a href='/topic/show?id=7435122e3c3' target=_blank style='color:#2F92EE;'>#MSCs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12273, encryptionId=7435122e3c3, topicName=MSCs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=18ac20929511, createdName=zhanfl, createdTime=Sat Jul 21 05:04:00 CST 2018, time=2018-07-21, status=1, ipAttribution=)]
    2019-03-04 lidong40
  6. [GetPortalCommentsPageByObjectIdResponse(id=1788853, encodeId=be491e8885354, content=<a href='/topic/show?id=866d1421e4c' target=_blank style='color:#2F92EE;'>#Physio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14217, encryptionId=866d1421e4c, topicName=Physio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Sep 29 20:04:00 CST 2018, time=2018-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961020, encodeId=69b519610204c, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sun Apr 07 20:04:00 CST 2019, time=2019-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1656168, encodeId=a6571656168f0, content=<a href='/topic/show?id=f4782246ec' target=_blank style='color:#2F92EE;'>#Akt#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2246, encryptionId=f4782246ec, topicName=Akt)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8c724776724, createdName=xfpan20, createdTime=Fri Dec 28 05:04:00 CST 2018, time=2018-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870751, encodeId=aaf518e0751d8, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Nov 15 10:04:00 CST 2018, time=2018-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2024147, encodeId=8c3a202414e85, content=<a href='/topic/show?id=bbba14239f5' target=_blank style='color:#2F92EE;'>#PI3K/AKT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14239, encryptionId=bbba14239f5, topicName=PI3K/AKT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Mon Mar 04 11:04:00 CST 2019, time=2019-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918202, encodeId=8624191820280, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Dec 16 15:04:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2069240, encodeId=a0f0206924016, content=<a href='/topic/show?id=7a7135902d' target=_blank style='color:#2F92EE;'>#BMSC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3590, encryptionId=7a7135902d, topicName=BMSC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=909c71, createdName=shijzhiewnjhch, createdTime=Wed May 29 04:04:00 CST 2019, time=2019-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789038, encodeId=56361e89038ea, content=<a href='/topic/show?id=e05d14241ae' target=_blank style='color:#2F92EE;'>#PI3K/Akt信号#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14241, encryptionId=e05d14241ae, topicName=PI3K/Akt信号)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80ca273, createdName=fanweitanzhen, createdTime=Sun May 19 06:04:00 CST 2019, time=2019-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625997, encodeId=1c78162599e4e, content=<a href='/topic/show?id=cb38968469' target=_blank style='color:#2F92EE;'>#IL-8#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9684, encryptionId=cb38968469, topicName=IL-8)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31920946979, createdName=respect, createdTime=Sat Jul 21 05:04:00 CST 2018, time=2018-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625916, encodeId=c47a162591621, content=<a href='/topic/show?id=7435122e3c3' target=_blank style='color:#2F92EE;'>#MSCs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12273, encryptionId=7435122e3c3, topicName=MSCs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=18ac20929511, createdName=zhanfl, createdTime=Sat Jul 21 05:04:00 CST 2018, time=2018-07-21, status=1, ipAttribution=)]
    2018-12-16 sunylz
  7. 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encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Nov 15 10:04:00 CST 2018, time=2018-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2024147, encodeId=8c3a202414e85, content=<a href='/topic/show?id=bbba14239f5' target=_blank style='color:#2F92EE;'>#PI3K/AKT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14239, encryptionId=bbba14239f5, topicName=PI3K/AKT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Mon Mar 04 11:04:00 CST 2019, time=2019-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918202, encodeId=8624191820280, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Dec 16 15:04:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2069240, encodeId=a0f0206924016, content=<a href='/topic/show?id=7a7135902d' target=_blank style='color:#2F92EE;'>#BMSC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3590, encryptionId=7a7135902d, topicName=BMSC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=909c71, createdName=shijzhiewnjhch, createdTime=Wed May 29 04:04:00 CST 2019, time=2019-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789038, encodeId=56361e89038ea, content=<a 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  8. 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    2018-07-21 zhanfl

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