Am J Neuroradiol:玩转3D DIR之强化前后3D 双翻转序列在多发性硬化中的应用!

2017-08-05 shaosai MedSci原创

多发性硬化(multiple sclerosis,MS)是以中枢神经系统(CNS)白质脱髓鞘病变为特点,遗传易感个体与环境因素作用发生的自身免疫性疾病。MS是中枢神经系统脱髓鞘疾病中最常见最主要的疾病。多发性硬化作为独立的疾病已有100余年的历史。因其有较高的发病率、慢性病程和青壮年易患而备受重视。其临床特征为发作性视神经、脊髓和脑部的局灶性障碍。这些神经障碍可有不同程度的缓解、复发。双翻转序列对

多发性硬化(multiple sclerosis,MS)是以中枢神经系统(CNS)白质脱髓鞘病变为特点,遗传易感个体与环境因素作用发生的自身免疫性疾病。MS是中枢神经系统脱髓鞘疾病中最常见最主要的疾病。多发性硬化作为独立的疾病已有100余年的历史。因其有较高的发病率、慢性病程和青壮年易患而备受重视。其临床特征为发作性视神经、脊髓和脑部的局灶性障碍。这些神经障碍可有不同程度的缓解、复发。双翻转序列对于MS病灶非常敏感。本研究旨在比较强化前后3D DIR序列和常规3D T1WI发现颅内MS病灶的差异,从而探究3D DIR是否能达到3D T1WI的诊断效果,并将结果发表在AJNR上。

本研究共纳入了自2013年6月-12月的45例MS或临床孤立综合征(CIS)。两位神经放射学医师独立地分析3D DIR强化前后以及剪影后图像、T1WI图像来计算强化病灶数目。然后,两位神经放射学医师对病变数目达成共识。利用Lin一致性计算两者一致性,利用独立样本T检验对发现病变能力的差异进行分析。另外,比较两种序列的对比噪声比。

与T1WI相比,DIR序列能够发现更多的强化病灶(16%, 214 versus 185, P = .007)。两位神经放射学医师的一致性很好(T1WI和DIR的ρ c分 别为0.94、0.98)。与T1WI相比,DIR剪影图像的对比噪声比要明显增高(DIR为14.3 ± 5.5; T1WI为6.3 ± 7.1; P < .001)。

本研究表明,与T1WI相比,DIR强化前后图像能够更好地发现颅内MS的强化病灶,从而可以作为标准MR扫描序列方案的可选择的扫描序列。

原始出处:

Eichinger P, Kirschke JS, Hoshi MM, et al,Pre- and Postcontrast 3D Double Inversion Recovery Sequence in Multiple Sclerosis: A Simple and Effective MR Imaging Protocol. Am J Neuroradiol. 2017.DOI: 10.3174/ajnr.A5329

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    2017-09-24 jml2009
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    2017-08-06 QQ25ed180f

    学习了,谢谢分享~

    0

  4. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLANEL7Sww3HicKsN9aribicAmGGWXOIMEiaZ1iadgZg9RibjqSwIKUS8gSPib2NwTVg2zVvVJhdP3BkuDIl/0, createdBy=944d1605392, createdName=shaosai, createdTime=Sat Aug 05 22:19:35 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230405, encodeId=0ea9230405a9, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Sat Aug 05 18:00:30 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230370, encodeId=72b22303e0cb, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQplCaQGBmjHytXQqvsuocO2uV2lOAaJibzDafJudKToVfU12LzwArHDb4TSrmU2hk5Qxzc6icoicBK3Dg/0, createdBy=a7901968505, createdName=明心见性, createdTime=Sat Aug 05 11:52:23 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-05 shaosai

    好好学习,谢谢分享!

    0

  5. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQplCaQGBmjHytXQqvsuocO2uV2lOAaJibzDafJudKToVfU12LzwArHDb4TSrmU2hk5Qxzc6icoicBK3Dg/0, createdBy=a7901968505, createdName=明心见性, createdTime=Sat Aug 05 11:52:23 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-05 往日如昨

    学习了谢谢分享

    0

  6. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQplCaQGBmjHytXQqvsuocO2uV2lOAaJibzDafJudKToVfU12LzwArHDb4TSrmU2hk5Qxzc6icoicBK3Dg/0, createdBy=a7901968505, createdName=明心见性, createdTime=Sat Aug 05 11:52:23 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-05 天地飞扬

    谢谢分享!

    0

  7. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQplCaQGBmjHytXQqvsuocO2uV2lOAaJibzDafJudKToVfU12LzwArHDb4TSrmU2hk5Qxzc6icoicBK3Dg/0, createdBy=a7901968505, createdName=明心见性, createdTime=Sat Aug 05 11:52:23 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-05 152****8376

    谢谢分享受益匪浅

    0

  8. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQplCaQGBmjHytXQqvsuocO2uV2lOAaJibzDafJudKToVfU12LzwArHDb4TSrmU2hk5Qxzc6icoicBK3Dg/0, createdBy=a7901968505, createdName=明心见性, createdTime=Sat Aug 05 11:52:23 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-05 医无止境。

    谢谢分享受益匪浅

    0

  9. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQplCaQGBmjHytXQqvsuocO2uV2lOAaJibzDafJudKToVfU12LzwArHDb4TSrmU2hk5Qxzc6icoicBK3Dg/0, createdBy=a7901968505, createdName=明心见性, createdTime=Sat Aug 05 11:52:23 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-05 flysky120

    希望能彻底治疗了

    0

  10. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQplCaQGBmjHytXQqvsuocO2uV2lOAaJibzDafJudKToVfU12LzwArHDb4TSrmU2hk5Qxzc6icoicBK3Dg/0, createdBy=a7901968505, createdName=明心见性, createdTime=Sat Aug 05 11:52:23 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-05 明心见性

    学习了,谢谢

    0

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MS病变多见于脑室旁白质静脉区,SWI之父就曾试图利用SWI来探究MS病变的分布机制是否与铁沉积相关,或者是与静脉狭窄相关。研究人员对MS与颈静脉的相关性提出质疑,并进行了相关研究,并将结果发表在Eur Radiol上。

JAMA Ophthalmol:角膜共焦显微镜检测多发性硬化患者角膜神经病变和树突细胞增加

角膜共焦显微镜显示多发性硬化患者的轴突变性和角膜的树突状细胞密度增加,膜共焦显微镜有望作为新的多发性硬化患者检测方法

多发性硬化影像诊断标准:中国专家共识

多发性硬化(multiple sclerosis, MS)是中枢神经系统脱髓鞘疾病的最常见类型,中青年人多见,致残率高,全球患者总数超过250万。MRI可以客观反映MS病灶和表现正常灰、白质的微观病理改变,协助鉴别诊断、评价治疗效果和判断预后。

New Engl J Med:遗传变异与多发性硬化和系统性红斑狼疮相关

每日健康---根据美国新英格兰医学杂志在4月26号的网上报到,目前确定了一种基因变异和多发性硬化(MS)及系统性红斑狼疮(SLE)都有相关性。