Neurology:额颞叶变性与外层视网膜变薄

2017-09-11 zhangfan MedSci原创

研究认为额颞叶变性与外层视网膜变薄有关,其程度可反映疾病的严重程度

阿尔茨海默病(AD)与光谱域光学相干断层扫描(SD-OCT)显示的内视网膜变薄之前的关系尚不清楚,近日研究人员考察了额颞叶变性(FTD)的视网膜特征。

在这项横断面研究中,38名FTD患者以及44名对照志愿者参与者,所有参与者进行标准化SD-OCT分析并进行眼间相关性的广义线性模型比较和简单精神状态检查(MMSE),利用临床诊断,遗传标记和脑脊液生物标志物判定参与者的AD病情。

在对年龄、性别以及种族进行调整后,额颞叶变性与外视网膜变薄相关(132 vs 142 μm, p = 0.004)。研究发现额颞叶变性患者外核层(ONL,88.5 vs 97.9 μm, p = 0.003) 以及蓝色区域 (EZ,14.5 vs 15.1 μm, p = 0.009)变薄,但视网膜内层厚度差异不显著。研究发现患者外层视网膜厚度与MMSE得分正相关 (r = 0.44, p = 0.03)。高度tau蛋白病变亚组中ONL (88.7 vs 97.4 μm, p = 0.01) 以及 EZ (14.4 vs 15.1 μm, p = 0.01)显著变薄。

研究认为额颞叶变性与外层视网膜变薄有关,其程度可反映疾病的严重程度。

原始出处:


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    2018-06-08 yinhl1978
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    2017-09-13 zutt
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    2017-09-13 huangdf
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    2017-09-12 meiliwuxian

    学习了

    0

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    2017-09-11 半夏微凉

    学习了谢谢分享

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2000098, encodeId=65ef200009847, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Jun 08 15:29:00 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269948, encodeId=3be71269948cc, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Wed Sep 13 05:29:00 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1463557, encodeId=53c2146355eed, content=<a href='/topic/show?id=7d27381288e' target=_blank style='color:#2F92EE;'>#变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38128, encryptionId=7d27381288e, topicName=变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f69f6545041, createdName=huangdf, createdTime=Wed Sep 13 05:29:00 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243103, encodeId=947224310355, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=445f1740270, createdName=meiliwuxian, createdTime=Tue Sep 12 07:36:06 CST 2017, time=2017-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=242907, encodeId=abeb24290e8a, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Mon Sep 11 15:43:05 CST 2017, time=2017-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=242905, encodeId=d2662429054f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfDEeydJz0GlP8O0ngrUX6AYCXFic0XDOOAyeQicIqnOd4TrWSwiagJrsFNYuWC1Uc6iavbS1hWt9xtZAhAqLGHqZyl/0, createdBy=42891977006, createdName=1e17414fm02(暂无匿称), createdTime=Mon Sep 11 15:35:50 CST 2017, time=2017-09-11, status=1, ipAttribution=)]
    2017-09-11 1e17414fm02(暂无匿称)

    学习

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