Cell:寨卡病毒导致小脑症在体外类器官模型中确证

2016-04-25 MedSci MedSci原创

寨卡病毒(Zika virus)疫情出现在研究大脑的新干细胞技术正在完善及进行测试之时。在4月22日的《细胞》(Cell)杂志上,来自约翰霍普金斯大学医学院的研究人员将一种脑区域特异性类器官(organoids)公诸于世,它在三维空间中展示了寨卡病毒影响人类大脑的机制。这些类器官数据支持了寨卡病毒偏好感染神经干细胞,及损伤程度差异取决于感染时间的这些观点。多年来大脑类器官(也叫微型大脑)一直被积极

寨卡病毒(Zika virus)疫情出现在研究大脑的新干细胞技术正在完善及进行测试之时。在4月22日的《细胞》(Cell)杂志上,来自约翰霍普金斯大学医学院的研究人员将一种脑区域特异性类器官(organoids)公诸于世,它在三维空间中展示了寨卡病毒影响人类大脑的机制。这些类器官数据支持了寨卡病毒偏好感染神经干细胞,及损伤程度差异取决于感染时间的这些观点。

多年来大脑类器官(也叫微型大脑)一直被积极地用于研究之中,然而高昂的成本、大多数实验室无法获得,以及棘手的实验方案阻碍明确的对照实验限制了它们。由宋红军(Hongjun Song)和明国丽(Guo-Li Ming)领导的研究小组,通过3D打印微型的旋转生物反应器,来利用人类干细胞批量生产出脑区域特异性类器官,解决了这些问题。

Thumbnail image of Figure 1. Opens large image

Figure 1 SpinΩ Bioreactor-based Forebrain Organoid Culture System

宋红军和明国丽是一对神仙眷侣,他们早在北京大学读书的时候就已经相恋了,现在两人在事业上又相辅相成,共同在神经科学领域取得了一个又一个的成就,联合署名发表在Cell、PNAS、Nat Neurosci等国际权威学术期刊上的研究论文已达70余篇。

今年3月初,宋红军、明国丽参与的一个研究小组在Cell Stem Cell杂志上发表论文,帮助将寨卡病毒感染与神经干细胞死亡联系到一起,但这些先导实验是在二维组织培养物中完成,无法完全重演正常大脑发育的一些特征(Cell Stem Cell:华人夫妇揭示寨卡病毒导致小头症的秘密,破坏神经干细胞)。

这些生物反应器使得研究人员能够做他们想做的研究——即在发育神经组织中观察寨卡病毒感染。“当出现寨卡病毒危机之时,我们看到我们拥有了完美的系统来研究这一病毒的影响,”约翰霍普金斯大学医学院细胞工程学研究所干细胞项目负责人宋红军说。

这些微型生物反应器可用生成三种类型的脑区域特异性类器官(前脑、中脑和下丘脑),它们可以存活及生长长达100天。这一时间跨度允许研究人员在与极早期和中期妊娠相当的发育阶段中诱导寨卡病毒感染。三维实验复制出了以往的研究发现:寨卡病毒喜欢感染神经干细胞,支持了在怀孕的前三个月发育大脑风险最大这一临床发现。

约翰霍普金斯大学医学院神经学教授明国丽说:“当受到寨卡病毒感染时,类器官要小得多,它们不会有效地生成神经元。在后期,你仍然可以看到病毒偏好感染神经祖细胞,尽管也感染了一些神经元,细胞死亡和增殖减少与我们在二维培养物中观察到的结果相一致。”

宋红军说:“来自寨卡病毒的数据确实凸显了这一模型系统的能力,我们可以在这一系统中研究疾病的不同阶段,观察感染背后的机制。有了这一生物反应器,现在这一模型有能力作为潜在疗法的临床前试验基地。”

当前,研究人员正向科学界提供他们Cell论文中的技术,并在这些类器官上测试一些FDA批准的化合物,看看是否有任一种化合物可以控制寨卡病毒感染,如何将一种潜在的寨卡病毒疗法传送给胎儿是未来的另一个挑战。

有关类器官的研究

类器官是指在实验室中培养,模拟器官自然形成过程的组织团块。近年来,各个领域的研究人员都已经开始利用人类干细胞培育微型器官,来更好地了解发育和疾病,加速新药开发。

2014年,由纪念斯隆凯特林癌症中心领导的一项研究,第一次证实了可以在实验室培育出源自人类前列腺肿瘤的类器官,为研究人员提供了一个令人兴奋的新工具来测试癌症药物和个体化的癌症疗法。研究结果发表在Cell杂志上(Cell:华人学者首次培育出前列腺癌类器官

2014年,美国科学家在实验室成功引导人类干细胞经过胚胎阶段发育,培养出微型“胃”。虽然这块活组织比一粒芝麻大不了多少,却有着和人胃一样的腺体结构,甚至还能容纳肠道菌。研究人员指出,该研究打开了一扇窗,让人们看到在人类胚胎变形阶段细胞是怎样发育成器官的。(Nature:美用多能干细胞培育出胃组织),以及在小鼠体内培养人类肠组织Nat Med:小鼠体内培养人类肠组织,个性化疗法新思路

2015年5月,研究人员利用由癌症患者肿瘤衍生出的三维(3D)类器官,接近复制出了原发肿瘤的一些关键特性。这些“类器官”培养物适用于大规模的药物筛查来检测与药物敏感性相关的一些遗传改变,为采用个体化治疗改善癌症患者的临床结局铺平了道路。他们将这项研究发表在Cell杂志上(Cell:首个癌症类器官生物银行)。

同年,马普研究所的Thomas F. Meyer领导研究团队建立了长期稳定的输卵管3D类器官。他们找到了能满足输卵管细胞特殊需求的培养条件,确保了输卵管成体干细胞的存活,并帮助这些干细胞增殖和分化。这项研究发表在Nature Communications杂志上(科学家建立首个输卵管类器官 )。

科学家已经将自闭症患者的皮肤细胞诱导转化成多功能干细胞,并在培养皿中培育为微型大脑,揭示了孤独症令人意外的发病机制。研究人员称,这种方法允许他们克服理解疾病(如自闭症,精神分裂症等)的困难,包括影响与疾病复杂性相关的大脑发育的困难以及研究人类组织的发展过程中困难。(Cell:重大突破!皮肤细胞诱导成大脑类器官,揭示了孤独症的发病机制)

来自康奈尔大学的研究人员们,人工合成了一种功能性的免疫器官,它可以分泌出抗体,而且可以在完全离体的情况下,在实验室里被操控。这个第一次人工合成的,独一无二的免疫器官是在Ankur Singh实验室内完成的,此项研究结果在线发表于Biomaterials杂志上。(Biomaterials: 首次人工合成的功能性免疫器官)

最近在心脏组织方面也有一些新进展,如皮肤干细胞培育出人类“迷你”心脏,助力筛查药物 和Sci Rep:使用iPS细胞制造出迷你心肌组织,可以用于药物测试

原始出处:

Cell, Qian and Nguyen et al.: "Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure" http://dx.doi.org/10.1016/j.cell.2016.04.032

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1869346, encodeId=8cc118693460c, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat May 14 01:40:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959603, encodeId=b71019596038e, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Feb 15 03:40:00 CST 2017, time=2017-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85285, encodeId=fe878528597, content=学习了,很好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Tue May 10 12:24:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1359999, encodeId=ac27135999990, content=<a href='/topic/show?id=6783466083f' target=_blank style='color:#2F92EE;'>#寨卡病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46608, encryptionId=6783466083f, topicName=寨卡病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Apr 26 23:40:00 CST 2016, time=2016-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512822, encodeId=87781512822db, content=<a href='/topic/show?id=f0364660360' target=_blank style='color:#2F92EE;'>#寨卡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46603, encryptionId=f0364660360, topicName=寨卡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d79610514526, createdName=12498710m14暂无昵称, createdTime=Tue Apr 26 23:40:00 CST 2016, time=2016-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=82776, encodeId=e47a82e7662, content=不错,学习了,赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=841a1636000, createdName=lietome1, createdTime=Tue Apr 26 08:01:00 CST 2016, time=2016-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=82757, encodeId=c22d82e5722, content=佩服,不断学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b711667381, createdName=JBY, createdTime=Mon Apr 25 23:39:00 CST 2016, time=2016-04-25, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1869346, encodeId=8cc118693460c, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat May 14 01:40:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959603, encodeId=b71019596038e, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Feb 15 03:40:00 CST 2017, time=2017-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85285, encodeId=fe878528597, content=学习了,很好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Tue May 10 12:24:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1359999, encodeId=ac27135999990, content=<a href='/topic/show?id=6783466083f' target=_blank style='color:#2F92EE;'>#寨卡病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46608, encryptionId=6783466083f, topicName=寨卡病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Apr 26 23:40:00 CST 2016, time=2016-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512822, encodeId=87781512822db, content=<a href='/topic/show?id=f0364660360' target=_blank style='color:#2F92EE;'>#寨卡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46603, encryptionId=f0364660360, topicName=寨卡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d79610514526, createdName=12498710m14暂无昵称, createdTime=Tue Apr 26 23:40:00 CST 2016, time=2016-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=82776, encodeId=e47a82e7662, content=不错,学习了,赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=841a1636000, createdName=lietome1, createdTime=Tue Apr 26 08:01:00 CST 2016, time=2016-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=82757, encodeId=c22d82e5722, content=佩服,不断学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b711667381, createdName=JBY, createdTime=Mon Apr 25 23:39:00 CST 2016, time=2016-04-25, status=1, ipAttribution=)]
    2017-02-15 维他命
  3. [GetPortalCommentsPageByObjectIdResponse(id=1869346, encodeId=8cc118693460c, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat May 14 01:40:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959603, encodeId=b71019596038e, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Feb 15 03:40:00 CST 2017, time=2017-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85285, encodeId=fe878528597, content=学习了,很好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Tue May 10 12:24:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1359999, encodeId=ac27135999990, content=<a href='/topic/show?id=6783466083f' target=_blank style='color:#2F92EE;'>#寨卡病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46608, encryptionId=6783466083f, topicName=寨卡病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Apr 26 23:40:00 CST 2016, time=2016-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512822, encodeId=87781512822db, content=<a href='/topic/show?id=f0364660360' target=_blank style='color:#2F92EE;'>#寨卡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46603, encryptionId=f0364660360, topicName=寨卡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d79610514526, createdName=12498710m14暂无昵称, createdTime=Tue Apr 26 23:40:00 CST 2016, time=2016-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=82776, encodeId=e47a82e7662, content=不错,学习了,赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=841a1636000, createdName=lietome1, createdTime=Tue Apr 26 08:01:00 CST 2016, time=2016-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=82757, encodeId=c22d82e5722, content=佩服,不断学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b711667381, createdName=JBY, createdTime=Mon Apr 25 23:39:00 CST 2016, time=2016-04-25, status=1, ipAttribution=)]
    2016-05-10 stead

    学习了,很好的

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1869346, encodeId=8cc118693460c, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat May 14 01:40:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959603, encodeId=b71019596038e, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Feb 15 03:40:00 CST 2017, time=2017-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85285, encodeId=fe878528597, content=学习了,很好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Tue May 10 12:24:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1359999, encodeId=ac27135999990, content=<a href='/topic/show?id=6783466083f' target=_blank style='color:#2F92EE;'>#寨卡病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46608, encryptionId=6783466083f, topicName=寨卡病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Apr 26 23:40:00 CST 2016, time=2016-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512822, encodeId=87781512822db, content=<a href='/topic/show?id=f0364660360' target=_blank style='color:#2F92EE;'>#寨卡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46603, encryptionId=f0364660360, topicName=寨卡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d79610514526, createdName=12498710m14暂无昵称, createdTime=Tue Apr 26 23:40:00 CST 2016, time=2016-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=82776, encodeId=e47a82e7662, content=不错,学习了,赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=841a1636000, createdName=lietome1, createdTime=Tue Apr 26 08:01:00 CST 2016, time=2016-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=82757, encodeId=c22d82e5722, content=佩服,不断学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b711667381, createdName=JBY, createdTime=Mon Apr 25 23:39:00 CST 2016, time=2016-04-25, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1869346, encodeId=8cc118693460c, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat May 14 01:40:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959603, encodeId=b71019596038e, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Feb 15 03:40:00 CST 2017, time=2017-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85285, encodeId=fe878528597, content=学习了,很好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Tue May 10 12:24:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1359999, encodeId=ac27135999990, content=<a href='/topic/show?id=6783466083f' target=_blank style='color:#2F92EE;'>#寨卡病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46608, encryptionId=6783466083f, topicName=寨卡病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Apr 26 23:40:00 CST 2016, time=2016-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512822, encodeId=87781512822db, content=<a href='/topic/show?id=f0364660360' target=_blank style='color:#2F92EE;'>#寨卡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46603, encryptionId=f0364660360, topicName=寨卡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d79610514526, createdName=12498710m14暂无昵称, createdTime=Tue Apr 26 23:40:00 CST 2016, time=2016-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=82776, encodeId=e47a82e7662, content=不错,学习了,赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=841a1636000, createdName=lietome1, createdTime=Tue Apr 26 08:01:00 CST 2016, time=2016-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=82757, encodeId=c22d82e5722, content=佩服,不断学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b711667381, createdName=JBY, createdTime=Mon Apr 25 23:39:00 CST 2016, time=2016-04-25, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1869346, encodeId=8cc118693460c, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat May 14 01:40:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959603, encodeId=b71019596038e, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Feb 15 03:40:00 CST 2017, time=2017-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85285, encodeId=fe878528597, content=学习了,很好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Tue May 10 12:24:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1359999, encodeId=ac27135999990, content=<a href='/topic/show?id=6783466083f' target=_blank style='color:#2F92EE;'>#寨卡病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46608, encryptionId=6783466083f, topicName=寨卡病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Apr 26 23:40:00 CST 2016, time=2016-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512822, encodeId=87781512822db, content=<a href='/topic/show?id=f0364660360' target=_blank style='color:#2F92EE;'>#寨卡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46603, encryptionId=f0364660360, topicName=寨卡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d79610514526, createdName=12498710m14暂无昵称, createdTime=Tue Apr 26 23:40:00 CST 2016, time=2016-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=82776, encodeId=e47a82e7662, content=不错,学习了,赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=841a1636000, createdName=lietome1, createdTime=Tue Apr 26 08:01:00 CST 2016, time=2016-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=82757, encodeId=c22d82e5722, content=佩服,不断学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b711667381, createdName=JBY, createdTime=Mon Apr 25 23:39:00 CST 2016, time=2016-04-25, status=1, ipAttribution=)]
    2016-04-26 lietome1

    不错,学习了,赞一个

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1869346, encodeId=8cc118693460c, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat May 14 01:40:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959603, encodeId=b71019596038e, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Feb 15 03:40:00 CST 2017, time=2017-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85285, encodeId=fe878528597, content=学习了,很好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Tue May 10 12:24:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1359999, encodeId=ac27135999990, content=<a href='/topic/show?id=6783466083f' target=_blank style='color:#2F92EE;'>#寨卡病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46608, encryptionId=6783466083f, topicName=寨卡病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Apr 26 23:40:00 CST 2016, time=2016-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512822, encodeId=87781512822db, content=<a href='/topic/show?id=f0364660360' target=_blank style='color:#2F92EE;'>#寨卡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46603, encryptionId=f0364660360, topicName=寨卡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d79610514526, createdName=12498710m14暂无昵称, createdTime=Tue Apr 26 23:40:00 CST 2016, time=2016-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=82776, encodeId=e47a82e7662, content=不错,学习了,赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=841a1636000, createdName=lietome1, createdTime=Tue Apr 26 08:01:00 CST 2016, time=2016-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=82757, encodeId=c22d82e5722, content=佩服,不断学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b711667381, createdName=JBY, createdTime=Mon Apr 25 23:39:00 CST 2016, time=2016-04-25, status=1, ipAttribution=)]
    2016-04-25 JBY

    佩服,不断学习

    0

相关资讯

巴西新生儿小头症确诊逾千例 200多例死亡

当地时间4月5日,巴西卫生部发布的最新疫情报告称,截至4月2日,巴西新生儿小头畸形症病例的确诊数量已达1046例,比一周前增加102例。其中,在孕期或产后因小头症或中枢神经系统其他变化导致的死亡报告数达227例。 巴西自2015年10月22日启动关于小头症病例的登记调查制度以来,截至4月2日,全国共报告6906例新生儿小头症疑似病例,其中排除1814例,确诊1046例,另外4046例仍在检

“寨卡”大起底

尽管将寨卡病毒同神经系统疾病联系起来的证据有限,但潜在的严重风险要求采取果断且及时的行动。 在巴西累西腓市,一名儿科医生测量患有小头症的婴儿头部。 图片来源:Mario Tama 去年10月之前,对寨卡病毒了解较多的少数科学家会用两个词概括它:基本无害。 这在很大程度上仍是正确的。主要通过埃及伊蚊传播的寨卡病毒,在大多数受感染者身上并不会引发症状。即便

寨卡或许比想象更可怕:可能导致神经系统疾病

●疾病预防控制中心已经得出结论,认为寨卡是引起新生儿小头症以及其他婴儿脑部严重缺陷的病源。    ●关于寨卡病毒,我们现在观察到的远比最初以为的要可怕得多。   面对寨卡,科学界刚刚赢得了一场战役,然而整个战争却还远远没有结束。 刊登在4月13日的《新英格兰医学杂志》上的一项研究,首次确认了寨卡与新生儿小头症的关联,证实了孕妇感染该病毒将会导致胎儿头部发

欧盟拨款1000万欧元资助寨卡病毒研究

欧盟委员会3月15日宣布,将从“地平线2020”科研规划中拨款1000万欧元,资助寨卡病毒研究。 欧盟委员会表示,这1000万欧元将首先用于研究寨卡病毒与新生儿小头症之间的关联。一旦证实二者之间确实存在联系,研究人员将继续研发抗寨卡病毒的方法,包括开发病毒检测方法以及就可能的治疗方法或疫苗开展试验。 主管卫生与食品安全的欧盟委员维特尼斯·安德柳凯蒂斯表示,欧盟范围内已有一些旅行者从美洲寨卡疫区

美疾控中心呼吁加强应对寨卡:比想象可怕

据外媒11日报道,美国疾病控制与预防中心的官员说,寨卡病毒给美国带来的影响可能要比人们此前预测的还“可怕”。寨卡病毒不仅可能造成婴儿大脑的损坏,还会对成年人造成神经系统问题。 自去年从巴西爆发以来,寨卡病毒已经导致美洲数以千计婴儿的出生缺陷。这种病也被称为“小头症”。 来自美国疾病控制与预防中心的专家舒查特(Dr. Anne Schuchat)表示,一系列出生缺陷的问题都与寨卡病毒有关

广东已通报8例输入性寨卡病例

广东省卫生和计划生育委员会3月11日通报,我省新增1例输入性寨卡病毒感染病例,截至目前,广东已经通报了8例输入性寨卡病毒感染病例。 省卫计委通报,患者为来自委内瑞拉(该国为寨卡病毒疫情发生国)的华侨(男,19岁),在广东省的住址为江门恩平市。2月29日从委内瑞拉回国抵粤,3月9日,当地医疗机构在对发生疫情国家返乡人员进行健康随访时发现患者有皮疹,立即将其进行隔离治疗。经省疾控中心复核检测,患者标