Sci Rep:在膀胱上皮通过连接蛋白43半通道进行的ATP释放生理协调研究

2018-02-12 AlexYang MedSci原创

膀胱存贮能力的昼夜变化对于舒适的睡眠是必不可少的。连接蛋白43(Cx43)是一种主要的间隙连接蛋白,并且在其他细胞类型中形成半通道作为ATP传输通路,并且膀胱利用ATP作为一种机械力转导信号来调控它的存储能力。最近,有研究人员阐释了膀胱上皮的昼夜节律钟能够通过Cx43半通道调控白天ATP的释放。Cx43在人类和小鼠尿道上皮中表达,并且通过Cx43的表达和细胞外ATP释放到膀胱腔的日常循环,来促使生

膀胱存贮能力的昼夜变化对于舒适的睡眠是必不可少的。连接蛋白43(Cx43)是一种主要的间隙连接蛋白,并且在其他细胞类型中形成半通道作为ATP传输通路,并且膀胱利用ATP作为一种机械力转导信号来调控它的存储能力。

最近,有研究人员阐释了膀胱上皮的昼夜节律钟能够通过Cx43半通道调控白天ATP的释放。Cx43在人类和小鼠尿道上皮中表达,并且通过Cx43的表达和细胞外ATP释放到膀胱腔的日常循环,来促使生物钟节律基因在小鼠上皮中的节律性表达变化。研究人员在永生性人类上皮细胞中同样观察到了Cx43和ATP相同的随着时间发生的变化,但是这些时间的变化在心律不齐的Bmal1敲除小鼠和BAMAL1敲除的上皮细胞中丧失。Cx43的过表达可以增加ATP的释放并且在Cx43敲除的小鼠中或者在Cx43半通道阻滞剂存在情况下ATP释放减少,这也表明了Cx43半通道是上皮ATP释放调控成员之一。

因此,研究人员指出,在上皮中存在着一种生理性节律,协同Cx43的表达及其半通道的作用,在上皮的转导和信号传递中,为ATP释放提供了一种直接的途径。

原始出处:

Atsushi Sengiku, Masakatsu Ueda, Jin Kono et al. Circadian coordination of ATP release in the urothelium via connexin43 hemichannels. Sci Rep. 31 Jan 2018.

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    2018-02-17 梦想起航ing

    学习了.新观点.新思路

    0

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    2018-02-17 梦想起航ing

    学习了

    0

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    2018-02-17 1ddf0692m34(暂无匿称)

    学习了.谢谢分享

    0

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    2018-02-16 1e0f8808m18(暂无匿称)

    好文章.学习了..

    0

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    2018-02-16 神功盖世

    0

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    2018-02-16 紫迎馨

    关注

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2076120, encodeId=501920e612030, content=<a href='/topic/show?id=abf6945365f' target=_blank style='color:#2F92EE;'>#连接蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94536, encryptionId=abf6945365f, topicName=连接蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6393434, createdName=ailian1202, createdTime=Sun Apr 29 18:02:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1751442, encodeId=238b1e514427d, content=<a href='/topic/show?id=3ba692039f7' target=_blank style='color:#2F92EE;'>#调研#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92039, encryptionId=3ba692039f7, topicName=调研)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=958d36313994, createdName=天堂的云, createdTime=Sat Apr 14 18:02:00 CST 2018, time=2018-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288656, encodeId=0d68288656e1, content=学习了.新观点.新思路, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/17/cfa76f1048392033b44c71e9bcb628d9.jpg, createdBy=096c2156900, createdName=梦想起航ing, createdTime=Sat Feb 17 09:57:12 CST 2018, time=2018-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288655, encodeId=60932886558c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/17/cfa76f1048392033b44c71e9bcb628d9.jpg, createdBy=096c2156900, createdName=梦想起航ing, createdTime=Sat Feb 17 09:56:21 CST 2018, time=2018-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288635, encodeId=41e22886354f, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Feb 17 09:16:25 CST 2018, time=2018-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288413, encodeId=77cf288413f3, content=好文章.学习了.., beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri Feb 16 14:47:28 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288394, encodeId=2c3628839415, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Fri Feb 16 11:54:49 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288389, encodeId=3be3288389a1, content=关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/11/eb1f237032e0bf07b10833fc3722e645.jpg, createdBy=2fed2145219, createdName=紫迎馨, createdTime=Fri Feb 16 11:35:33 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461666, encodeId=948d146166661, content=<a href='/topic/show?id=6f3829619b' target=_blank style='color:#2F92EE;'>#ATP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2961, encryptionId=6f3829619b, topicName=ATP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d5806435870, createdName=listen320, createdTime=Wed Feb 14 09:02:00 CST 2018, time=2018-02-14, status=1, ipAttribution=)]
    2018-02-14 listen320

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