SCI REP:非酒精性脂肪肝加速慢性肾脏病患者肾功能下降!

2018-03-17 xing.T MedSci原创

由此可见,NAFLD与CKD进展独立相关。

近日,Scientific reports杂志上发表了一篇研究文章,该研究旨在探讨慢性肾脏病(CKD)患者非酒精性脂肪肝(NAFLD)及其严重程度与肾功能下降的关系。

研究人员对2003年1月至2013年12月期间接受了多次健康检查的1525名CKD患者进行了队列研究。NAFLD是经超声进行诊断,其严重程度由NAFLD纤维化评分进行评估。

在基线时,NAFLD的患病率为40.9%,而平均估计的肾小球滤过率(eGFR)为59.1 ml/min/1.73m2。平均随访6.5年,年龄和性别调整后的eGFR降幅在NAFLD患者中较大(每年为-0.79%,95%可信区间为-1.31%至-0.27%),相比于那些没有NAFLD的患者(0.30%,95%可信区间为-0.14%至0.76%;P=0.002)。在多变量校正模型中,NAFLD患者eGFR下降每年变化百分比的平均差异为-1.06%(-1.73%至-0.38%;P=0.002)。eGFR下降与NAFLD纤维化评分较高的NAFLD患者相关,在那些有蛋白尿或较低基线eGFR(<45 ml/min/1.73m2),以及那些吸烟和高血压患者中。

由此可见,NAFLD与CKD进展独立相关。

原始出处:

Hye Ryoun Jang,et al. Nonalcoholic fatty liver disease accelerates kidney function decline in patients with chronic kidney disease: a cohort study.Scientific reports.2018. https://www.nature.com/articles/s41598-018-23014-0

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    2018-09-26 yese
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    2018-11-04 1de33e15m69(暂无匿称)

    太可怕了,我现在就已经脂肪肝八年多,可能还有慢性肾炎,只是临床上没有确诊而已

    0

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  8. [GetPortalCommentsPageByObjectIdResponse(id=1850661, encodeId=99451850661b4, content=<a href='/topic/show?id=46c682469e4' target=_blank style='color:#2F92EE;'>#肾功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82469, encryptionId=46c682469e4, topicName=肾功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Wed Sep 26 09:58:00 CST 2018, time=2018-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351550, encodeId=af5a3515501a, content=太可怕了,我现在就已经脂肪肝八年多,可能还有慢性肾炎,只是临床上没有确诊而已, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2531680715, createdName=1de33e15m69(暂无匿称), createdTime=Sun Nov 04 21:27:29 CST 2018, time=2018-11-04, status=1, ipAttribution=), 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likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Mar 17 15:30:09 CST 2018, time=2018-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297130, encodeId=6d0829e13064, content=好好努力.继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Mar 17 14:40:12 CST 2018, time=2018-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297122, encodeId=ec5c29e122b0, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/iaAVWEsIJUkA1ITy3uL0lhHUhyaJibWgFtH4KbJuaLbY2WUK33jgCFyoZ8Eqx7eE7hCuZhytc1C5GRrfjVXN8lYg/0, createdBy=fcb82149579, createdName=183****7028, createdTime=Sat Mar 17 14:03:06 CST 2018, time=2018-03-17, status=1, ipAttribution=)]
    2018-03-17 1e0f8808m18(暂无匿称)

    脂肪肝加重肾病肾功下降.

    0

  9. 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likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Mar 17 15:30:09 CST 2018, time=2018-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297130, encodeId=6d0829e13064, content=好好努力.继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Mar 17 14:40:12 CST 2018, time=2018-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297122, encodeId=ec5c29e122b0, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2018-03-17 忠诚向上

    好好努力.继续学习

    0

  10. 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    2018-03-17 183****7028

    学习

    0

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