JCEM:CD36调节空腹和吸收前激素及胆汁酸水平

2018-03-13 MedSci MedSci原创

大家都知道脂肪酸(FA)代谢异常可以导致糖尿病和心血管疾病。FA的受体CD36与代谢综合征的风险有关。在啮齿类动物中,CD36调节脂肪代谢的各个方面,但它在人类中是否具有相似的作用尚不清楚。近日在JCEM上发表的一篇文章则研究了CD36编码单核苷酸多态性对餐后激素和胆汁酸(BA)反应的影响。

大家都知道脂肪酸(FA)代谢异常可以导致糖尿病和心血管疾病。FA的受体CD36与代谢综合征的风险有关。在啮齿类动物中,CD36调节脂肪代谢的各个方面,但它在人类中是否具有相似的作用尚不清楚。近日在JCEM上发表的一篇文章则研究了CD36编码单核苷酸多态性对餐后激素和胆汁酸(BA)反应的影响。

为了检查编码CD36变体rs3211938(G / T)的CD36水平降低约50%的次要等位基因(G)是否影响对高脂肪膳食(HFM)的激素应答,研究人员在HFM之前和之后研究了携带rs3211938(G / T)的G等位基因的肥胖非裔美国(AA)女性和重量匹配的非携带者。测定血浆激素(c-肽,胰岛素,肠促胰岛素,生长素释放肽,FGF19,FGF21),BA和血清脂蛋白(乳糜微粒,VLDL)的早期预吸收反应(10分钟)和延长的偏移。

研究结果显示在空腹时,G等位基因携带者显着降低了胆固醇和甘油脱氧胆酸,以及血清脂蛋白一致但非显着的降低。 GLP-1和胰多肽(PP)的水平降低60-70%,总BA的水平升高1.8倍。餐后,G等位基因携带者在胰岛素,c-肽,GLP-1,GIP和PP早期(-10至10分钟)表现出减毒反应。 BA在G等位基因携带者与非携带者携带差异FGF19应答中表现出不同的趋势。

上述研究结果表明CD36在协调能量代谢的脑和肠调节的预吸收激素和BA反应中起重要作用。

原始出处:

Cyndya A Shibao.et al. CD36 modulates fasting and preabsorptive hormone and bile acid levels. J Clin Endocrinol Metab. 2018.

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    2019-02-03 smallant2015
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    2018-11-16 achengzhao
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    2018-03-15 yfjms

    学习

    0

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    2018-03-15 crystal0568
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    2018-03-13 changjiu

    学习一下谢谢

    0

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    2018-03-13 有备才能无患

    大家都知道脂肪酸(FA)代谢异常可以导致糖尿病和心血管疾病.FA的受体CD36与代谢综合征的风险有关.在啮齿类动物中.CD36调节脂肪代谢的各个方面.但它在人类中是否具有相似的作用尚不清楚.近日在JCEM上发表的一篇文章则研究了CD36编码单核苷酸多态性对餐后激素和胆汁酸(BA)反应的影响.

    0

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