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JCI：细胞因子疗法增强NK细胞杀伤肿瘤细胞能力

2014-10-24 佚名 生物谷

细胞因子肿瘤细胞
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自然杀伤细胞(NK，natural killer cell)是免疫系统中的哨兵，可以快速响应并杀死病变细胞。NK细胞是能针对和消除表面缺乏蛋白MHC I类的细胞，然而许多肿瘤细胞缺少这种蛋白，能抵抗NK细胞的监视和杀伤。 在Journal of Clinical Investigation杂志上的一项新研究显示，细胞因子治疗能增强NK细胞杀伤缺乏MHC I类肿瘤细胞的能力。 利用小鼠模型

自然杀伤细胞(NK，natural killer cell)是免疫系统中的哨兵，可以快速响应并杀死病变细胞。NK细胞是能针对和消除表面缺乏蛋白MHC I类的细胞，然而许多肿瘤细胞缺少这种蛋白，能抵抗NK细胞的监视和杀伤。

在Journal of Clinical Investigation杂志上的一项新研究显示，细胞因子治疗能增强NK细胞杀伤缺乏MHC I类肿瘤细胞的能力。

利用小鼠模型，加州大学伯克利分校David Raulet确定，缺乏MHC-I类的肿瘤细胞会灭活NK细胞。

由MHC I类阳性肿瘤细胞和MHC I类阴性肿瘤细胞组成的混合瘤也会引起NK细胞变得无响应。重要的是，治疗MHC I类缺陷的肿瘤小鼠，用细胞因子IL-12和IL-18或突变形式的IL-2可恢复NK细胞活性，减少肿瘤大小，并增加小鼠存活。

这项研究的调查结果支持细胞因子治疗或许可用于治疗肿瘤细胞缺乏MHC I类的患者。

原始出处

Ardolino M, Azimi CS, Iannello A, Trevino TN, Horan L, Zhang L, Deng W, Ring AM, Fischer S, Garcia KC, Raulet DH.Cytokine therapy reverses NK cell anergy in MHC-deficient tumors.J Clin Invest. 2014 Oct 20.

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    2015-09-16 ms7019579240139182

    #胞因子#

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    2015-01-26 caobinglei8079

    #JCI#

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    2014-10-26 axin009

    #细胞因子#

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    2014-10-26 hmwwww

    #肿瘤细胞#

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