Crit Care Med：16S核糖体RNA基因技术揭示了急性胰腺炎患者菌血症有啥特点？

2017-03-18 xing.T MedSci原创

该研究对急性胰腺炎患者菌血症的发病率和细菌种类的特点提供了一个详细的描述。该研究证明菌血症和疾病的严重程度之间存在相关性，这使我们能够更好地了解细菌易位在急性胰腺炎感染性并发症的发病机制中的潜在作用。

危重病医学领域权威杂志Critical Care Medicine上发表了一篇研究文章，研究人员旨在探究急性胰腺炎患者菌血症的特点并明确其与病情严重程度之间可能相关性。

这项前瞻性对照研究是在中国金陵医院ICU科完成的。该研究的参与者共纳入48例轻、重症急性胰腺炎患者。没有进行任何干预措施。

研究人员在急性胰腺炎患者被明确诊断后的第4或5天以及第9或10天采集外周血样本。研究人员采用使用变性梯度凝胶电泳分析从血液中得到的DNA，将分离的片段进行测序，以确定细菌种类。外周血中检测到细菌DNA的急性胰腺炎患者有68.8%，超过一半（60.4%）的患者检测到了微生物菌群。急性胰腺炎患者易位的细菌主要是来自于肠道条件致病菌，包括大肠杆菌、肠杆菌科细菌、福氏志贺菌、鲁氏不动杆菌、凝结芽孢杆菌以及屎肠球菌。不同严重程度患者的循环中细菌种类发生明显改变。菌血症与急性胰腺炎患者急性生理学和慢性健康状况II评分呈显著正相关（r=0.7918，P＜0.0001）。

由此可见，该研究对急性胰腺炎患者菌血症的发病率和细菌种类的特点提供了一个详细的描述。该研究证明菌血症和疾病的严重程度之间存在相关性，这使我们能够更好地了解细菌易位在急性胰腺炎感染性并发症的发病机制中的潜在作用。

原始出处：

Li, Qiurong, et al. Bacteremia in the Patients With Acute Pancreatitis as Revealed by 16S Ribosomal RNA Gene-Based Techniques.Critical Care Medicine.doi: 10.1097/CCM.0b01e1828adba

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2017-07-24 heli0118

#基因技术#

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2017-03-20 Tommy1949

#菌血症#

24 0
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2017-03-20 ms3994565386320060

#Med#

24 0
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2017-03-20 lcm1028

学习了！涨知识了！谢谢分享！

67 0
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2017-03-19 孙文杰

不错

66 0
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2017-03-19 jiuling

学习了谢谢分享

58 0
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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Mar 19 06:31:46 CST 2017, time=2017-03-19, status=1, ipAttribution=)]
2017-03-19 1e10c84am36(暂无匿称)

文章很好，值得分享

56 0
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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Mar 19 06:31:46 CST 2017, time=2017-03-19, status=1, ipAttribution=)]
2017-03-19 明月清辉

谢谢分享，学习了

60 0
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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Mar 19 08:12:19 CST 2017, time=2017-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181044, encodeId=4976181044ec, content=相关性不是很高嘛, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Sun Mar 19 06:51:11 CST 2017, time=2017-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181035, encodeId=c7c318103504, content=学习新知识，谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Mar 19 06:31:46 CST 2017, time=2017-03-19, status=1, ipAttribution=)]
2017-03-19 医艺依意

相关性不是很高嘛

24 0
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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Mar 19 06:31:46 CST 2017, time=2017-03-19, status=1, ipAttribution=)]
2017-03-19 刘煜

学习新知识，谢谢分享。

24 0