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JBMR：机械应力刺激维持骨重建稳态与miRNA-103a有关

2014-10-02 MedSci MedSci原创

应力骨重建
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上海生命科学研究院健康所张晓玲研究员与新华医院陈晓东教授合作研究发现力学敏感性miRNA-103a通过靶向于Runx2负调控骨形成。国际骨矿研究领域权威学术期刊Journal of Bone and Mineral Research在线发表了健康科学研究所张晓玲研究员与新华医院陈晓东教授合作完成的最新研究成果论文“microRNA-103a functions as a mec

上海生命科学研究院健康所张晓玲研究员与新华医院陈晓东教授合作研究发现力学敏感性miRNA-103a通过靶向于Runx2负调控骨形成。国际骨矿研究领域权威学术期刊Journal of Bone and Mineral Research在线发表了健康科学研究所张晓玲研究员与新华医院陈晓东教授合作完成的最新研究成果论文“microRNA-103a functions as a mechno-sensitive microRNA to inhibit bone formation through targeting Runx2”。

适度的机械应力刺激对于维持骨重建稳态至关重要，应力刺激减小如临床长期卧床患者可导致废用性骨质疏松，而异常的机械应力刺激可导致临床疲劳性骨折的发生，目前临床尚缺乏有效早期干预措施。博士研究生左斌等在张晓玲研究员及陈晓东教授的指导下发现力学敏感性microRNA-103a直接靶向成骨分化进程中关键转录因子Runx2进而抑制成骨细胞活性，在抑制骨形成中发挥至关重要的作用。研究发现在去载荷小鼠模型中抑制microRNA-103a可有效挽救小鼠的骨量丢失，部分反转骨质疏松表型。

抑制成骨细胞中的miR-103a有可能是改善机械载荷相关性临床疾病的一条有潜力的促合成代谢策略。该研究为临床上治疗载荷缺失所致废用性骨质疏松提供了新思路及药物靶点。


原始出处：
Zuo B, Zhu JF, Li J, Wang CD, Zhao XY, Cai GQ, Li Z, Peng J, Wang P, Shen C, Huang Y, Xu J, Zhang XL, Chen XD.microRNA-103a functions as a mechno-sensitive microRNA to inhibit bone formation through targeting Runx2. J Bone Miner Res. 2014 Sep 6. doi: 10.1002/jbmr.2352.

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    2015-06-05 ljjj1053

    好好学习学习

    0

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    2014-11-07 changfy

    #稳态#

    0

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    2014-12-22 智慧医人

    #骨重建#

    0

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    2015-07-25 smallant2002

    #miR#

    0

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    2014-10-04 Homburg

    #miRNA#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=26090, encodeId=b3b1260904f, content=好好学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Fri Jun 05 16:29:00 CST 2015, time=2015-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1646692, encodeId=80741646692bd, content=<a href='/topic/show?id=4478e5315e1' target=_blank style='color:#2F92EE;'>#稳态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75315, encryptionId=4478e5315e1, topicName=稳态)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3ebc23344390, createdName=changfy, createdTime=Fri Nov 07 17:16:00 CST 2014, time=2014-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710486, encodeId=fb311e1048658, content=<a href='/topic/show?id=ecec10189e7b' target=_blank style='color:#2F92EE;'>#骨重建#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101897, encryptionId=ecec10189e7b, topicName=骨重建)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Mon Dec 22 14:16:00 CST 2014, time=2014-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1930399, encodeId=c16a1930399f4, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Sat Jul 25 10:16:00 CST 2015, time=2015-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312263, encodeId=b90913122632d, content=<a href='/topic/show?id=e5571193321' target=_blank style='color:#2F92EE;'>#miRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11933, encryptionId=e5571193321, topicName=miRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87d405, createdName=Homburg, createdTime=Sat Oct 04 03:16:00 CST 2014, time=2014-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591066, encodeId=e6581591066a0, content=<a href='/topic/show?id=ed574924e8c' target=_blank style='color:#2F92EE;'>#应力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49247, encryptionId=ed574924e8c, topicName=应力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=jiangjun073, createdTime=Sat Oct 04 03:16:00 CST 2014, time=2014-10-04, status=1, ipAttribution=)]
    2014-10-04 jiangjun073

    #应力#

    0