Am J Clin Nutr：维生素B12与老年人神经功能研究

2016-08-24 Moon 译 MedSci原创

老化与维生素B12水平的逐步下降有关。明显的维生素B12缺乏会引起外周和中枢运动和感觉系统的神经系统紊乱，但在老年人中的低维生素B12水平对公众健康神经疾病的影响尚不清楚。观察性研究的证据母亲仍存在很多局限。研究者进行了研究，探究对于适度低维生素B12水平的无症状老年人，维生素B12水平是否与外周或中枢神经功能的电生理指标有关。研究者使用了英格兰东南部进行的增强神经功能研究数据，研究了维生素B12

老化与维生素B12水平的逐步下降有关。明显的维生素B12缺乏会引起外周和中枢运动和感觉系统的神经系统紊乱，但在老年人中的低维生素B12水平对公众神经系统疾病的影响尚不清楚。观察性研究的证据母亲仍存在很多局限。

研究者进行了研究，探究对于适度低维生素B12水平的无症状老年人，维生素B12水平是否与外周或中枢神经功能的电生理指标有关。

研究者使用了英格兰东南部进行的增强神经功能研究数据，研究了维生素B12补充剂对适度低维生素B12水平（血清维生素B12浓度 ≥107，以及<210 pmol/L，不伴贫血）的无症状老年人（平均年龄：80岁）神经功能电生理指标的有效性（n = 201）。维生素B12水平使用总维生素B12、全反钴氨素和维生素B12的综合指标(cB-12)进行评估。单一观察者对所有参与者的外周和中枢神经功能感觉和运动的电生理进行评估。

在多变量模型中，没有证据表明维生素B12、全反钴氨素和cB-12与任何神经传导结果相关；也没有证据表明维生素B12水平与神经功能的临床标志物有关。

对于适度低维生素B12水平的无症状老年人，本次高质量试验数据分析结果没有显示任何维生素B12水平与外周或中枢神经功能或任何神经功能的临床标志物之间的关联。这个研究结果可能不适合于不健康的更严重维生素B12缺乏的老年人群。

原始出处：

Miles LM.et al.Vitamin B-12 status and neurologic function in older people: a cross-sectional analysis of baseline trial data from the Older People and Enhanced Neurological Function (OPEN) study.Am J Clin Nutr. 2016 Aug 17. pii: ajcn137927. [Epub ahead of print]

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2016-09-15 ylzr123

点个赞！好文章有待学习探讨。

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2016-09-09 1e10c84am36(暂无匿称)

赞！好文章，拜读，深入学习。

47 0
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encodeId=4ac1103598e0, content=学习了，赞一个！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Thu Aug 25 16:26:00 CST 2016, time=2016-08-25, status=1, ipAttribution=)]
2016-09-03 李东泽

很好，不错，以后会多学习

47 0
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encodeId=4ac1103598e0, content=学习了，赞一个！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Thu Aug 25 16:26:00 CST 2016, time=2016-08-25, status=1, ipAttribution=)]
2016-08-26 ylzr123

好文章，值得学习，先赞一个

49 0
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encodeId=4ac1103598e0, content=学习了，赞一个！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Thu Aug 25 16:26:00 CST 2016, time=2016-08-25, status=1, ipAttribution=)]
2016-08-26 明崖

学习了，可以再研究研究

54 0
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2016-08-26 bnjfx@127.com

#维生素B12#

24 0
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encodeId=4ac1103598e0, content=学习了，赞一个！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Thu Aug 25 16:26:00 CST 2016, time=2016-08-25, status=1, ipAttribution=)]
2016-08-26 lhlxtx

#神经功能#

33 0
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encodeId=4ac1103598e0, content=学习了，赞一个！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Thu Aug 25 16:26:00 CST 2016, time=2016-08-25, status=1, ipAttribution=)]
2016-08-26 马龙

#维生素B#

24 0
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2016-08-25 1dd8a7c5m95(暂无匿称)

学习了，赞一个！！

20 0
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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Aug 26 14:52:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=104488, encodeId=defc104488d6, content=学习了，可以再研究研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Fri Aug 26 11:49:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414874, encodeId=df8014148e43e, content=<a href='/topic/show?id=e686e9057c7' target=_blank style='color:#2F92EE;'>#维生素B12#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79057, encryptionId=e686e9057c7, topicName=维生素B12)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b7303108315, createdName=bnjfx@127.com, createdTime=Fri Aug 26 10:45:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422052, encodeId=19b91422052d7, content=<a href='/topic/show?id=e5f0e42224f' target=_blank style='color:#2F92EE;'>#神经功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74222, encryptionId=e5f0e42224f, topicName=神经功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=85503680375, createdName=lhlxtx, createdTime=Fri Aug 26 10:45:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508507, encodeId=c70f150850e05, content=<a href='/topic/show?id=68b0e9055f7' target=_blank style='color:#2F92EE;'>#维生素B#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79055, encryptionId=68b0e9055f7, topicName=维生素B)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=17599981768, createdName=马龙, createdTime=Fri Aug 26 10:45:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=103602, encodeId=c1ad10360280, content=学习了，赞一个！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Thu Aug 25 16:27:00 CST 2016, time=2016-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=103598, encodeId=4ac1103598e0, content=学习了，赞一个！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Thu Aug 25 16:26:00 CST 2016, time=2016-08-25, status=1, ipAttribution=)]
2016-08-25 1dd8a7c5m95(暂无匿称)

学习了，赞一个！！

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