CLIN CANCER RES:Fenretinide静脉给药治疗复发或难治性血液系统恶性肿瘤

2017-08-23 MedSci MedSci原创

体外实验证实Fenretinide对淋巴细胞性白血病细胞系具有显著毒性作用,同时对成纤维细胞、外周血单核细胞以及髓系祖细胞的毒性很小,表明其在血液系统恶性肿瘤中具有治疗潜力。CLIN CANCER RES近期发表了一篇文章,研究Fenretinide静脉途径给药治疗血液系统恶性肿瘤的最大耐受剂量(MTD),剂量限制毒性(DLT)以及药代动力学。

体外实验证实Fenretinide对淋巴细胞性白血病细胞系具有显着毒性作用,同时对成纤维细胞、外周血单核细胞以及髓系祖细胞的毒性很小,表明其在血液系统恶性肿瘤中具有治疗潜力。CLIN CANCER RES近期发表了一篇文章,研究Fenretinide静脉途径给药治疗血液系统恶性肿瘤的最大耐受剂量(MTD),剂量限制毒性(DLT)以及药代动力学。

在21天的治疗周期中,在第1-5天通过静脉途径进行Fenretinide治疗。研究共纳入29例患者,97%的患者完成研究。5天最大耐受剂量为1280mg/m2。最常见的剂量限制毒性为高甘油三酯血症(6例),其中4例无临床症状。2例患者出现血小板减少症(无临床症状)。11例出现外周T淋巴细胞反应的患者中,2例出现完全反应(完全反应者,无进展生存68+个月,疑似完全反应者,无进展生存14+个月),2例出现疑似部分反应(无进展生存分别为5个月和6个月),5例出现病情稳定(2-12个周期)。1例成熟B细胞淋巴瘤的患者出现疑似部分反应,持续2个周期。剂量达到640mg/m2/day时,血浆稳定药物水平约为10mcg/ml,905mg/m2/day时血浆稳定药物水平约为14mcg/ml,1280mg/m2/day时血浆稳定药物水平约为22mcg/ml。

文章最后认为,与胶囊形式给药相比,静脉Fenretinide给药血浆药物水平显着提高,毒性在可接受范围内,并且对外周T细胞淋巴瘤具有抗肿瘤活性。推荐的Ⅱ期试验剂量为第1天600mg/m2,第2-5天1200mg/m2,周期21天。

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    2017-12-08 ysjykql
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createdName=三生有幸9135, createdTime=Wed Aug 23 18:05:41 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236407, encodeId=9a4b23640e48, content=学习了受益匪浅., beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Wed Aug 23 17:00:05 CST 2017, time=2017-08-23, status=1, ipAttribution=)]
    2017-11-05 fusion
  4. 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encryptionId=116d991e023, topicName=静脉给药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a5a149, createdName=gongliu, createdTime=Wed Jan 31 08:48:00 CST 2018, time=2018-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236922, encodeId=4b8e236922f0, content=好文.值得点赞!认真学习.应用于实践!谢谢分享给广大同好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Aug 25 08:11:51 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316305, encodeId=66b91316305c1, content=<a href='/topic/show?id=fa5689329c3' target=_blank style='color:#2F92EE;'>#血液系统恶性肿瘤#</a>, beContent=null, objectType=article, 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  5. 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encryptionId=116d991e023, topicName=静脉给药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a5a149, createdName=gongliu, createdTime=Wed Jan 31 08:48:00 CST 2018, time=2018-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236922, encodeId=4b8e236922f0, content=好文.值得点赞!认真学习.应用于实践!谢谢分享给广大同好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Aug 25 08:11:51 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316305, encodeId=66b91316305c1, content=<a href='/topic/show?id=fa5689329c3' target=_blank style='color:#2F92EE;'>#血液系统恶性肿瘤#</a>, beContent=null, objectType=article, 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createdName=三生有幸9135, createdTime=Wed Aug 23 18:05:41 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236407, encodeId=9a4b23640e48, content=学习了受益匪浅., beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Wed Aug 23 17:00:05 CST 2017, time=2017-08-23, status=1, ipAttribution=)]
    2017-08-25 ylzr123

    好文.值得点赞!认真学习.应用于实践!谢谢分享给广大同好!

    0

  6. 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  7. 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createdName=ysjykql, createdTime=Fri Dec 08 16:48:00 CST 2017, time=2017-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697526, encodeId=4627169e5265a, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Sun Nov 05 09:48:00 CST 2017, time=2017-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819063, encodeId=932f18190638e, content=<a href='/topic/show?id=116d991e023' target=_blank style='color:#2F92EE;'>#静脉给药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99170, encryptionId=116d991e023, topicName=静脉给药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a5a149, createdName=gongliu, createdTime=Wed Jan 31 08:48:00 CST 2018, time=2018-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236922, encodeId=4b8e236922f0, content=好文.值得点赞!认真学习.应用于实践!谢谢分享给广大同好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Aug 25 08:11:51 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316305, encodeId=66b91316305c1, content=<a href='/topic/show?id=fa5689329c3' target=_blank style='color:#2F92EE;'>#血液系统恶性肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89329, encryptionId=fa5689329c3, topicName=血液系统恶性肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Fri Aug 25 04:48:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1528378, encodeId=dbb515283e88b, content=<a href='/topic/show?id=74b798601a1' target=_blank style='color:#2F92EE;'>#难治性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98601, encryptionId=74b798601a1, topicName=难治性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1ef11916292, createdName=freve, createdTime=Fri Aug 25 04:48:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236433, encodeId=262a236433eb, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Wed Aug 23 18:16:37 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236426, encodeId=14bd236426fd, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Aug 23 18:05:41 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236407, encodeId=9a4b23640e48, content=学习了受益匪浅., beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Wed Aug 23 17:00:05 CST 2017, time=2017-08-23, status=1, ipAttribution=)]
    2017-08-25 freve
  8. 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encryptionId=116d991e023, topicName=静脉给药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a5a149, createdName=gongliu, createdTime=Wed Jan 31 08:48:00 CST 2018, time=2018-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236922, encodeId=4b8e236922f0, content=好文.值得点赞!认真学习.应用于实践!谢谢分享给广大同好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Aug 25 08:11:51 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316305, encodeId=66b91316305c1, content=<a href='/topic/show?id=fa5689329c3' target=_blank style='color:#2F92EE;'>#血液系统恶性肿瘤#</a>, beContent=null, objectType=article, 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236433, encodeId=262a236433eb, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Wed Aug 23 18:16:37 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236426, encodeId=14bd236426fd, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Aug 23 18:05:41 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236407, encodeId=9a4b23640e48, content=学习了受益匪浅., beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Wed Aug 23 17:00:05 CST 2017, time=2017-08-23, status=1, ipAttribution=)]
    2017-08-23 changjiu

    学习了.谢谢

    0

  9. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236433, encodeId=262a236433eb, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Wed Aug 23 18:16:37 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236426, encodeId=14bd236426fd, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Aug 23 18:05:41 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236407, encodeId=9a4b23640e48, content=学习了受益匪浅., beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Wed Aug 23 17:00:05 CST 2017, time=2017-08-23, status=1, ipAttribution=)]
    2017-08-23 三生有幸9135

    学习一下谢谢分享

    0

  10. 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    2017-08-23 131****1460

    学习了受益匪浅.

    0