Eur Heart J:右室功能障碍可预测射血分数正常心衰患者死亡

2014-06-05 高晓方 译 医学论坛网

美国一项研究表明,在射血分数正常心衰(HFpEF)患者中右心功能障碍较为常见,并且由右心室收缩受损和源于肺动脉高压的后负荷失调所引起。论文于5月29日在线发表于《欧洲心脏杂志》(Eur Heart J)。 此项研究共纳入96例HFpEF患者和46例对照者,并且均给予右心导管检查、超声心动图评估和随访。在HFpEF患者和对照者中对相关指标进行对比评估。以右心室面积变化分数(FAC)<35

美国一项研究表明,在射血分数正常心衰(HFpEF)患者中右心功能障碍较为常见,并且由右心室收缩受损和源于肺动脉高压的后负荷失调所引起。论文于5月29日在线发表于《欧洲心脏杂志》(Eur Heart J)。

此项研究共纳入96例HFpEF患者和46例对照者,并且均给予右心导管检查、超声心动图评估和随访。在HFpEF患者和对照者中对相关指标进行对比评估。以右心室面积变化分数(FAC)<35%定义右心室功能障碍。

结果显示,HFpEF患者的左右心充盈压、肺动脉压和右心室尺寸均大于对照者,左心室尺寸和EF则与后者相似。33%的HFpEF患者存在右心室功能障碍,并且与症状更重和共病负担更大具有相关性。与对照者相比,负荷依赖和非依赖性指数均显示HFpEF存在右心室功能受损。

除血液动力负荷外,右心室功能障碍还与男性、房颤、冠脉疾病和心室相互依存升高相关。

在中位随访的529天期间,31%的HFpEF患者死亡。在Cox分析中,右心室功能障碍为死亡的最显著预测因素。

原始出处:


Melenovsky V1, Hwang SJ2, Lin G2, Redfield MM2, Borlaug BA2.Right heart dysfunction in heart failure with preserved ejection fraction.Eur Heart J. 2014 May 29. pii: ehu193. 

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    2014-06-07 zhaojie88
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