Ann Rheum Dis:慢性广泛疼痛患者的死亡率过高

2017-07-22 xiangting MedSci原创

目前的证据显示CWP患者死亡率过高。英国Biobank的结果大大降低了过度风险大小的不确定性,并与不良生活方式因素所解释的过高死亡率相一致。

慢性广泛疼痛(CWP)患者是否会过早死亡仍不确定。使用目前最大的样本量,研究人员确定这种关系是否存在,估计其大小并确定是什么因素介导了这种关系。

英国Biobank是一项于2006-2010年在英国各地招募了40-69岁共50万人的队列研究。将报告"全身疼痛"> 3个月的参与者与没有慢性疼痛的人进行比较。有2015年年中以前的死亡信息(包括原因)。研究人员将这些结果和其他已发表的报道并入荟萃分析中,以计算汇总的过度风险。

共7130名参与者报告了CWP,他们的死亡率过高(死亡率风险比为2.43,95%CI 2.17至2.72)。过度死亡的具体原因是癌症(1.73 调整年龄和性别,95%CI 1.46至2.05),心血管疾病(3.24 调整年龄和性别,95%CI 2.55至4.11),呼吸系统疾病(5.66 调整年龄和性别,95%CI 4.00至8.03)和其他疾病相关原因(4.04 调整年龄和性别,95%CI 3.05至5.34)。根据体力劳动水平低、体质量指数高、饮食质量差、抽烟进行调整后,过度风险明显降低。在荟萃分析中,所有研究均显示出显著的过度全因死亡率(综合估计1.59(95%CI 1.05至2.42)),心血管和癌症死亡率。

目前的证据显示CWP患者死亡率过高。英国Biobank的结果大大降低了过度风险大小的不确定性,并与不良生活方式因素所解释的过高死亡率相一致,这可能成为管理这类患者的主要目标。

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    2017-07-22 1e0e5697m83(暂无匿称)

    henhao

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    2017-07-22 1e0e5a1fm42(暂无匿称)

    henhao

    0

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    2017-07-22 hhh678

    henhao

    0

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    2017-07-22 1e0ece0dm09(暂无匿称)

    谢谢分享

    0

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    2017-07-22 137****9095

    henhao

    0

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    2017-07-22 139****0239

    henhao

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2012329, encodeId=6e51201232919, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat May 26 09:03:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225067, encodeId=5d1222506e8a, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b10c1938054, createdName=1e0e5697m83(暂无匿称), createdTime=Sat Jul 22 11:00:10 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225061, encodeId=46a92250615d, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=7dcf1938111, createdName=1e0e5a1fm42(暂无匿称), createdTime=Sat Jul 22 10:56:42 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225048, encodeId=078322504881, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Sat Jul 22 10:42:37 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225020, encodeId=86c722502014, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Sat Jul 22 09:55:19 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=224997, encodeId=9f4322499e2c, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=353a2047758, createdName=137****9095, createdTime=Sat Jul 22 09:12:58 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=224993, encodeId=956b2249937e, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=80d11516357, createdName=139****0239, createdTime=Sat Jul 22 09:11:17 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=224987, encodeId=d2ef22498eeb, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sat Jul 22 09:07:01 CST 2017, time=2017-07-22, status=1, ipAttribution=)]
    2017-07-22 楠博One

    谢谢分享

    0