BMJ：酒精摄入与非致死性和致死性冠心病和卒中的关系

2018-06-01 xing.T MedSci原创

由此可见，酒精摄入与非致命性CHD风险呈负相关，但与不同卒中类型的风险呈正相关。这突出了酒精摄入量与不同CVD类型之间的对立关系，并增加了减少饮酒政策的证据。

近日，顶级杂志BMJ上发表了一篇研究文章，研究人员旨在评估酒精摄入量（基线和终身）与非致死性和致死性冠心病（CHD）和卒中之间的相关性。

这个多中心病例队列研究是来自于八个欧洲国家的癌症和营养队列（EPC-CVD）欧洲前瞻性调查中心血管疾病（CVD）决定因素的研究。该研究纳入了32549例基线无CVD的参与者，并进行亚组比较。该研究的主要结局为非致死性和致命性CHD和卒中（包括缺血性和出血性卒中）。

9307名参与者发生非致命性冠心病，1699名参与者发生致死性冠心病，5855名参与者发生非致命性卒中，733名参与者发生致死性卒中。基线酒精摄入量与非致死性CHD呈负相关，超过12g/天的酒精摄入量对应的风险比为0.94（95%可信区间为0.92至0.96）。基线酒精摄入量与致命性CHD风险之间存在J型关联。相比于0.1-4.9g/天的总酒精摄入量，5.0-14.9g/天、15.0-27.9g/天、30.0-59.9g/天的风险比分别为0.83（0.70-0.98）、0.65（0.53-0.81）和0.82（0.65-1.03）。相反，基线酒精摄入量每增加12g/天，非致命性和致命性卒中的风险比分别为1.04（1.02-1.07）和1.05（0.98-1.13），包括广泛相似的缺血性和出血性中风结果。没有强有力的证据表明饮酒与吸烟状况的交互作用对心血管事件的风险有影响。

由此可见，酒精摄入与非致命性CHD风险呈负相关，但与不同卒中类型的风险呈正相关。这突出了酒精摄入量与不同CVD类型之间的对立关系，并增加了减少饮酒政策的证据。

原始出处：

Cristian Ricci, et al. Alcohol intake in relation to non-fatal and fatal coronary heart disease and stroke: EPIC-CVD case-cohort study.BMJ 2018; https://doi.org/10.1136/bmj.k934

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2018-10-16 gaoxiaoe

#BMJ#

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2018-11-05 lqrandywkz

#酒精摄入#

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2018-07-07 dinorsor524

#非致死性#

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2018-06-03 andy2092

#致死性#

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createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Fri Jun 01 14:01:16 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
2018-06-02 1209e435m98(暂无昵称)

学习了.谢谢分享

69 0
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2018-06-02 大爰

学习了谢谢分享!!

71 0
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2018-06-01 健健

卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！

36 0
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createdName=lqrandywkz, createdTime=Mon Nov 05 13:43:00 CST 2018, time=2018-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819632, encodeId=f6a3181963256, content=<a href='/topic/show?id=86529966293' target=_blank style='color:#2F92EE;'>#非致死性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99662, encryptionId=86529966293, topicName=非致死性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e524260, createdName=dinorsor524, createdTime=Sat Jul 07 22:43:00 CST 2018, time=2018-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568257, encodeId=1485156825ebb, content=<a href='/topic/show?id=569d8644eb9' target=_blank style='color:#2F92EE;'>#致死性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86447, encryptionId=569d8644eb9, topicName=致死性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae1815335551, createdName=andy2092, createdTime=Sun Jun 03 04:43:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320716, encodeId=c80b320e16cd, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Jun 02 06:34:24 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320689, encodeId=e27b320689a5, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Fri Jun 01 15:05:32 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320560, encodeId=cf0c320560a2, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Fri Jun 01 14:23:59 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320550, encodeId=67eb3205506e, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Fri Jun 01 14:01:16 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
2018-06-01 139****5926

好好文章学习了

86 0
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createdName=lqrandywkz, createdTime=Mon Nov 05 13:43:00 CST 2018, time=2018-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819632, encodeId=f6a3181963256, content=<a href='/topic/show?id=86529966293' target=_blank style='color:#2F92EE;'>#非致死性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99662, encryptionId=86529966293, topicName=非致死性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e524260, createdName=dinorsor524, createdTime=Sat Jul 07 22:43:00 CST 2018, time=2018-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568257, encodeId=1485156825ebb, content=<a href='/topic/show?id=569d8644eb9' target=_blank style='color:#2F92EE;'>#致死性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86447, encryptionId=569d8644eb9, topicName=致死性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae1815335551, createdName=andy2092, createdTime=Sun Jun 03 04:43:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320716, encodeId=c80b320e16cd, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Jun 02 06:34:24 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320689, encodeId=e27b320689a5, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Jun 02 06:13:48 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026061, encodeId=9b3d102606149, content=卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Fri Jun 01 16:43:00 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320571, encodeId=e8ed3205e1e2, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Fri Jun 01 15:05:32 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320560, encodeId=cf0c320560a2, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Fri Jun 01 14:23:59 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320550, encodeId=67eb3205506e, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Fri Jun 01 14:01:16 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
2018-06-01 smartxiuxiu

好

61 0
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createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Fri Jun 01 14:01:16 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
2018-06-01 惠映实验室

学习了.谢谢分享.

51 0

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