CLIN CHEM:血浆游DNA用于头颈癌的疾病分层和预后

2018-06-21 MedSci MedSci原创

在头颈部鳞状细胞癌(HNSCC)患者的疾病分层和预后预测中,临床医生面临着许多挑战。鉴于目前使用的临床评分,重复活检和成像技术的局限性,液体活检方法可提供有价值的额外诊断和预后信息。 利用临床资料和来自HNSCC患者的血浆样本进行非介入性单中心观察研究。通过低覆盖率新一代测序(NGS)在116名患者中测定血浆游离DNA衍生的拷贝数异常(CNA)。将重要的CNA合并在全基因组拷贝数不稳定性评分

在头颈部鳞状细胞癌(HNSCC)患者的疾病分层和预后预测中,临床医生面临着许多挑战。鉴于目前使用的临床评分,重复活检和成像技术的局限性,液体活检方法可提供有价值的额外诊断和预后信息。

利用临床资料和来自HNSCC患者的血浆样本进行非介入性单中心观察研究。通过低覆盖率新一代测序(NGS)在116名患者中测定血浆游离DNA衍生的拷贝数异常(CNA)。将重要的CNA合并在全基因组拷贝数不稳定性评分(CNI)中,其针对常规临床分期和患者结果进行评估。

接受者操作特征(ROC)曲线分析比较患者(n = 103)和无瘤对照(n = 142)患者术前CNI产生的ROC曲线下面积为87.2%(95CI79.4 -93.3%)。在95%的特异性下,检测肿瘤的灵敏度在46%(pT1)和94%(pT4)之间变化。高于中位数(即> 72)的CNI对于淋巴结受累(LNI)的阳性预测值为90%(95CI79-96%),而阴性预测值为57%(95CI 43-70%)。对于CNI> 72,总生存(OS)更差(风险比,4.89; 95CI1.39-17.17; P= 0.01),术后3年分别有62%和90%的生存者分别为CNI> 72和≤72。在多变量模型中,与包括LNI在内的已建立的疾病特征相比,CNIOS的优越预测指标。

研究表明,CNI可能有助于预测HNSCC中的LNI和预后,并提示需要进行颈淋巴结清除术或更积极的治疗

原始出处:

Markus A. Schirmer, Julia Beck, Martin Leu, Cell-Free Plasma DNA for Disease Stratification and Prognosis in Head and Neck Cancer.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1295888, encodeId=67c0129588819, content=<a href='/topic/show?id=f30a4441598' target=_blank style='color:#2F92EE;'>#头颈癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44415, encryptionId=f30a4441598, topicName=头颈癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c32257, createdName=DEXTER3139, createdTime=Sat Jun 23 02:11:00 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326099, encodeId=427e32609964, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Fri Jun 22 11:56:51 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325847, encodeId=c70e32584e0b, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Jun 21 12:26:26 CST 2018, time=2018-06-21, status=1, ipAttribution=)]
    2018-06-22 1209e435m98(暂无昵称)

    学习了.谢谢分享

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  3. [GetPortalCommentsPageByObjectIdResponse(id=1295888, encodeId=67c0129588819, content=<a href='/topic/show?id=f30a4441598' target=_blank style='color:#2F92EE;'>#头颈癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44415, encryptionId=f30a4441598, topicName=头颈癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c32257, createdName=DEXTER3139, createdTime=Sat Jun 23 02:11:00 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326099, encodeId=427e32609964, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Fri Jun 22 11:56:51 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325847, encodeId=c70e32584e0b, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Jun 21 12:26:26 CST 2018, time=2018-06-21, status=1, ipAttribution=)]
    2018-06-21 1ddf0692m34(暂无匿称)

    学习了.长知识

    0