J Colloid Interface Sci:使用万古霉素还原氧化石墨烯用于抗菌

2018-05-05 MedSci MedSci原创

化学还原氧化石墨烯氧化物(GO)是大规模生产石墨烯基材料的一种简单且廉价的方法。对于还原GO(RGO)的生产,高度需求合适的还原剂,特别是绿色还原剂。本研究中,研究人员使用万古霉素(一种用于治疗多种革兰氏阳性细菌感染的糖肽抗生素)在弱碱性pH下化学还原GO。据我们所知,这是糖肽类抗生素还原GO的首例报道。使用红外和拉曼光谱,X-射线衍射图以及原子力显微镜(AFM)表征万古霉素缀合的RGO(RGO-

化学还原氧化石墨烯氧化物(GO)是大规模生产石墨烯基材料的一种简单且廉价的方法。对于还原GO(RGO)的生产,高度需求合适的还原剂,特别是绿色还原剂。本研究中,研究人员使用万古霉素(一种用于治疗多种革兰氏阳性细菌感染的糖肽抗生素)在弱碱性pH下化学还原GO。据我们所知,这是糖肽类抗生素还原GO的首例报道。

使用红外和拉曼光谱,X-射线衍射图以及原子力显微镜(AFM)表征万古霉素缀合的RGO(RGO-Van)。通过细菌生长曲线研究了RGO-Van在菌悬液中的抗菌效果。RGO-Van薄片可以通过真空过滤制成纸状薄膜。通过抑菌试验和细菌粘附测定来评估所获得的RGO-Van膜的抗菌性能。

使用金黄色葡萄球菌感染大鼠建立伤口感染大鼠模型,验证了RGO-Van膜的抗菌功效。

原始出处:

Xu LQ, Liao YB, et al., Vancomycin-assisted green synthesis of reduced graphene oxide for antimicrobial applications. J Colloid Interface Sci. 2018 Mar 15;514:733-739. doi: 10.1016/j.jcis.2018.01.014. Epub 2018 Jan 4.

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    2019-01-09 shanyongle
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    2018-05-05 虈亣靌

    学习了.谢谢作者分享!

    0

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    2018-05-05 三生有幸9135

    学习一下谢谢分享

    0

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近日,中国科学院上海药物研究所黄蔚课题组与蓝乐夫课题组在ACS期刊《医药化学杂志》(Journal of Medicinal Chemistry)发表了题为“Extra sugar on vancomycin: new analogues for combating multidrug-resistant Staphylococcus aureus and vancomycin-resistant Enterococci”文章,报道了新型糖肽抗生素衍生物,针对多重耐药的金黄色葡萄球菌和粪肠球菌抗菌活性高于万古霉素128-1024倍。