J Thromb Haemost:高血小板计数和高血细胞比容与动静脉血栓形成的关系

2019-07-17 xing.T MedSci原创

在这项前瞻性研究中,高血小板计数与大脑动脉血栓形成风险增加1.8倍相关,而高血细胞比容与心脏动脉血栓形成风险增加1.5倍相关。

目前尚不清楚高血小板计数或高血细胞比容是否可预测一般人群血栓形成的风险。近日,血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章,研究人员旨在检验这样一个假设:高血小板计数或高血细胞比容的个体具有较高的动脉和静脉血栓形成的风险。

研究人员前瞻性地随访了来自哥本哈根一般人群研究的108521名受试者,中位随访时间为8年。在研究开始时测量血小板计数和血液血细胞比容。 

血小板计数在最高5个百分位数(>398x109/L)与第25-75百分位数(231-316x109/L)的个体相比,大脑动脉血栓形成的多变量校正风险比为1.77(95%CI为1.38-2.24)(38和26次事件/10000人每年),心脏动脉血栓形成的风险比为0.82(0.61-1.11)(23和28次事件/10000人每年)。对于血细胞比容值在最高5个百分位数(女性/男性:>45%/>48%)与第25-75百分位数(女性/男性:38.1-42%/41.1-45%)的个体相比,脑内动脉血栓形成的风险比为1.27(0.91-1.75)(40和26次事件/10000人每年),心脏动脉血栓形成的风险比为1.46(1.06-2.00)(43和25次事件/10000人每年)。高血小板计数和高血细胞比容都与静脉血栓栓塞的风险无关。当从主要分析中排除患有骨髓增生性肿瘤的个体时,血栓形成风险的结果是相似的。

在这项前瞻性研究中,高血小板计数与大脑动脉血栓形成风险增加1.8倍相关,而高血细胞比容与心脏动脉血栓形成风险增加1.5倍相关。 

原始出处:

Marie Warny.et al.Arterial and venous thrombosis by high platelet count and high hematocrit: 108,521 individuals from the Copenhagen General Population Study.Journal of Thrombosis and Haemostasis.2019.https://doi.org/10.1111/jth.14574

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    2020-02-04 changfy
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    2019-08-09 fusion
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    2020-06-05 xue8602
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