J Periodontol:非手术治疗是否可以减少局部侵袭性牙周炎的JP2

2017-11-23 MedSci MedSci原创

以前的研究已经提供了伴放线放线杆菌和高度破坏白细胞的JP2基因型与局部侵袭性牙周炎(LAgP)关系的实质证据。本研究旨在评估牙周治疗后LAgP患者中JP2的情况。

以前的研究已经提供了伴放线放线杆菌和高度破坏白细胞的JP2基因型与局部侵袭性牙周炎(LAgP)关系的实质证据。本研究旨在评估牙周治疗后LAgP患者中JP2的情况。

方法:检查60例5?25岁的LAgP非裔美国患者。在治疗前,测量探诊深度(PD),临床附着水平(CAL),探查出血和菌斑指数,并且收集每个参与者的LAgP和健康位点的龈下菌斑。患者接受全口腔超声洁治,刮治和根面平整,以及为期7天的阿莫西林和甲硝唑治疗。参与者重新检测和采样,并在治疗后的第3,6和12个月接受定期维持治疗。使用聚合酶链式反应来检测处理之前和之后的JP2基因型。

结果:术前,75%的LAgP位点和56.67%的健康位点可以鉴定出JP2序列。治疗后3,6,12个月,患者数分别为40,31和31,疾病位点JP2检出率分别下降到17.5%,6.45%,3.23%(P <0.001);健康位点分别为2.5%,3.23%和0%(P <0.001)。治疗后临床参数也显着降低(P <0.001)。此外,在治疗后JP2与平均PD(P <0.002)和CAL(P <0.001)之间相关性显着。

结论:牙周治疗能有效减少疾病和健康位点的临床参数和龈下JP2。

原始出处:

Danielle K. Burgess, et al. Non-Surgical Therapy Reduces Presence of JP2 Clone in Localized Aggressive Periodontitis. Journal of Periodontology . 2017 December. doi: 10.1902/jop.2017.170285

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    2017-11-25 chg122
  5. 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  8. 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    2017-11-25 lyh994

    全口腔超声洁治.刮治和根面平整

    0

  9. 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    2017-11-25 chunjianf

    学习了.谢谢分享

    0

  10. 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    2017-11-24 yfjms

    学习

    0

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