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国内首例婴儿型Pierson综合征在北大医院确诊

2015-06-04 付东红 cmt

Pierson综合征婴儿型
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北京大学第一医院(北大医院)儿科肾脏专业组近日诊断了国内首例婴儿型Pierson综合征，这也是已知国内报道的第2例Pierson综合征，均由北大医院儿科肾脏专业组诊断。 据北大医院副院长、儿科肾脏专业组丁洁教授介绍，Pierson综合征是一种儿科罕见的遗传性肾脏疾病，常染色体隐性遗传，1963年被认识，2004年明确其病因为编码层粘蛋白β2的基因(laminin-β2 gene，LAMB

北京大学第一医院(北大医院)儿科肾脏专业组近日诊断了国内首例婴儿型Pierson综合征，这也是已知国内报道的第2例Pierson综合征，均由北大医院儿科肾脏专业组诊断。

据北大医院副院长、儿科肾脏专业组丁洁教授介绍，Pierson综合征是一种儿科罕见的遗传性肾脏疾病，常染色体隐性遗传，1963年被认识，2004年明确其病因为编码层粘蛋白β2的基因(laminin-β2 gene，LAMB2)突变所致。典型的临床表现为先天性肾病综合征和明显的眼部异常，其中眼部异常以小瞳孔、晶状体形状异常、白内障等为主要特征。发病后通常会快速进展至肾衰竭。

研究证实，LAMB2基因突变相关的疾病谱是多样的，可以表现为婴儿型、儿童型遗传性肾病综合征，或者表现为先天性肾病综合征而没有眼部异常等。另外，如果携带突变基因的患者能活过婴儿期，常会出现失明和严重的神经系统缺陷。临床上有该突变基因的患者于出生后3个月内发病者占87%，其中85%左右1岁内肾衰竭;个别于出生后3个月到1岁、1岁以后发病，进展至肾衰竭的年龄不一，约1岁～16岁。典型病例的肾脏病理类型为弥漫性系膜硬化(diffuse mesangial sclerosis，DMS)，也可以表现为局灶增生性肾小球硬化或系膜增生性肾小球病变，可能与发病年龄及临床症状轻重有关。

该疾病在治疗上有什么措施?丁洁指出，这个疾病不像其他后天罹患的肾病综合征用激素和免疫抑制剂治疗。而激素耐药，免疫抑制剂治疗也无效。因此确诊极其重要!首先避免盲目应用激素和免疫抑制剂，因为这类药物毒副作用大。北大医院之前诊断的那例患儿，大约在其他医院历经2年后到北大医院才得以确诊，期间就误用了激素和免疫抑制剂，导致患儿承受了更多因药物副作用带来的痛苦。

另外，对于Pierson综合征确诊的另一个重要性是，对于这样的家庭再生育风险的预测，因为该病为常染色体隐性遗传，因此再生育风险为25%。再有，由于进行了突变基因的诊断，因此这个家庭如果再次生育还可以考虑进行产前基因诊断、甚至种植前基因诊断，以助于优生优育。

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    2016-05-04 zhlpower

    #北大医院#

    0

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    2016-02-25 仁者大医

    #ERS#

    0

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    2015-07-18 zhangph

    #大医院#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1723238, encodeId=d4581e23238b3, content=<a href='/topic/show?id=27a633e1015' target=_blank style='color:#2F92EE;'>#北大医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33710, encryptionId=27a633e1015, topicName=北大医院)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6da833418759, createdName=zhlpower, createdTime=Wed May 04 11:48:00 CST 2016, time=2016-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878107, encodeId=c3cd18e810732, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Thu Feb 25 21:48:00 CST 2016, time=2016-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1910127, encodeId=e42d191012ec0, content=<a href='/topic/show?id=0e4e43635a6' target=_blank style='color:#2F92EE;'>#大医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43635, encryptionId=0e4e43635a6, topicName=大医院)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Sat Jul 18 09:48:00 CST 2015, time=2015-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430527, encodeId=c583143052e61, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Jun 06 05:48:00 CST 2015, time=2015-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26001, encodeId=b5f826001e5, content=保佑, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7911626942, createdName=s312486, createdTime=Thu Jun 04 18:15:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25958, encodeId=64a6259581b, content=恩, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160804/IMG57A2EF131ACE72300.jpg, createdBy=a2811610046, createdName=黄庆, createdTime=Thu Jun 04 16:57:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25936, encodeId=623625936ee, content=待研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d231626576, createdName=jjzouyan, createdTime=Thu Jun 04 15:59:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25924, encodeId=d20925924c4, content=的确有待研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f8011617873, createdName=bucm_ting, createdTime=Thu Jun 04 15:33:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25922, encodeId=422b2592285, content=有待深入研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e511627114, createdName=1dd7eb8am26(暂无匿称), createdTime=Thu Jun 04 15:28:00 CST 2015, time=2015-06-04, status=1, ipAttribution=)]
    2015-06-06 zhouqu_8

    #综合征#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1723238, encodeId=d4581e23238b3, content=<a href='/topic/show?id=27a633e1015' target=_blank style='color:#2F92EE;'>#北大医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33710, encryptionId=27a633e1015, topicName=北大医院)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6da833418759, createdName=zhlpower, createdTime=Wed May 04 11:48:00 CST 2016, time=2016-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878107, encodeId=c3cd18e810732, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Thu Feb 25 21:48:00 CST 2016, time=2016-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1910127, encodeId=e42d191012ec0, content=<a href='/topic/show?id=0e4e43635a6' target=_blank style='color:#2F92EE;'>#大医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43635, encryptionId=0e4e43635a6, topicName=大医院)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Sat Jul 18 09:48:00 CST 2015, time=2015-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430527, encodeId=c583143052e61, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Jun 06 05:48:00 CST 2015, time=2015-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26001, encodeId=b5f826001e5, content=保佑, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7911626942, createdName=s312486, createdTime=Thu Jun 04 18:15:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25958, encodeId=64a6259581b, content=恩, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160804/IMG57A2EF131ACE72300.jpg, createdBy=a2811610046, createdName=黄庆, createdTime=Thu Jun 04 16:57:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25936, encodeId=623625936ee, content=待研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d231626576, createdName=jjzouyan, createdTime=Thu Jun 04 15:59:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25924, encodeId=d20925924c4, content=的确有待研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f8011617873, createdName=bucm_ting, createdTime=Thu Jun 04 15:33:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25922, encodeId=422b2592285, content=有待深入研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e511627114, createdName=1dd7eb8am26(暂无匿称), createdTime=Thu Jun 04 15:28:00 CST 2015, time=2015-06-04, status=1, ipAttribution=)]
    2015-06-04 s312486

    保佑

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1723238, encodeId=d4581e23238b3, content=<a href='/topic/show?id=27a633e1015' target=_blank style='color:#2F92EE;'>#北大医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33710, encryptionId=27a633e1015, topicName=北大医院)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6da833418759, createdName=zhlpower, createdTime=Wed May 04 11:48:00 CST 2016, time=2016-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878107, encodeId=c3cd18e810732, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Thu Feb 25 21:48:00 CST 2016, time=2016-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1910127, encodeId=e42d191012ec0, content=<a href='/topic/show?id=0e4e43635a6' target=_blank style='color:#2F92EE;'>#大医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43635, encryptionId=0e4e43635a6, topicName=大医院)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Sat Jul 18 09:48:00 CST 2015, time=2015-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430527, encodeId=c583143052e61, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Jun 06 05:48:00 CST 2015, time=2015-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26001, encodeId=b5f826001e5, content=保佑, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7911626942, createdName=s312486, createdTime=Thu Jun 04 18:15:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25958, encodeId=64a6259581b, content=恩, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160804/IMG57A2EF131ACE72300.jpg, createdBy=a2811610046, createdName=黄庆, createdTime=Thu Jun 04 16:57:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25936, encodeId=623625936ee, content=待研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d231626576, createdName=jjzouyan, createdTime=Thu Jun 04 15:59:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25924, encodeId=d20925924c4, content=的确有待研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f8011617873, createdName=bucm_ting, createdTime=Thu Jun 04 15:33:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25922, encodeId=422b2592285, content=有待深入研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e511627114, createdName=1dd7eb8am26(暂无匿称), createdTime=Thu Jun 04 15:28:00 CST 2015, time=2015-06-04, status=1, ipAttribution=)]
    2015-06-04 黄庆

    恩

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1723238, encodeId=d4581e23238b3, content=<a href='/topic/show?id=27a633e1015' target=_blank style='color:#2F92EE;'>#北大医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33710, encryptionId=27a633e1015, topicName=北大医院)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6da833418759, createdName=zhlpower, createdTime=Wed May 04 11:48:00 CST 2016, time=2016-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878107, encodeId=c3cd18e810732, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Thu Feb 25 21:48:00 CST 2016, time=2016-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1910127, encodeId=e42d191012ec0, content=<a href='/topic/show?id=0e4e43635a6' target=_blank style='color:#2F92EE;'>#大医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43635, encryptionId=0e4e43635a6, topicName=大医院)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Sat Jul 18 09:48:00 CST 2015, time=2015-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430527, encodeId=c583143052e61, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Jun 06 05:48:00 CST 2015, time=2015-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26001, encodeId=b5f826001e5, content=保佑, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7911626942, createdName=s312486, createdTime=Thu Jun 04 18:15:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25958, encodeId=64a6259581b, content=恩, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160804/IMG57A2EF131ACE72300.jpg, createdBy=a2811610046, createdName=黄庆, createdTime=Thu Jun 04 16:57:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25936, encodeId=623625936ee, content=待研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d231626576, createdName=jjzouyan, createdTime=Thu Jun 04 15:59:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25924, encodeId=d20925924c4, content=的确有待研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f8011617873, createdName=bucm_ting, createdTime=Thu Jun 04 15:33:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25922, encodeId=422b2592285, content=有待深入研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e511627114, createdName=1dd7eb8am26(暂无匿称), createdTime=Thu Jun 04 15:28:00 CST 2015, time=2015-06-04, status=1, ipAttribution=)]
    2015-06-04 jjzouyan

    待研究

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1723238, encodeId=d4581e23238b3, content=<a href='/topic/show?id=27a633e1015' target=_blank style='color:#2F92EE;'>#北大医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33710, encryptionId=27a633e1015, topicName=北大医院)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6da833418759, createdName=zhlpower, createdTime=Wed May 04 11:48:00 CST 2016, time=2016-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878107, encodeId=c3cd18e810732, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Thu Feb 25 21:48:00 CST 2016, time=2016-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1910127, encodeId=e42d191012ec0, content=<a href='/topic/show?id=0e4e43635a6' target=_blank style='color:#2F92EE;'>#大医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43635, encryptionId=0e4e43635a6, topicName=大医院)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Sat Jul 18 09:48:00 CST 2015, time=2015-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430527, encodeId=c583143052e61, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Jun 06 05:48:00 CST 2015, time=2015-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26001, encodeId=b5f826001e5, content=保佑, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7911626942, createdName=s312486, createdTime=Thu Jun 04 18:15:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25958, encodeId=64a6259581b, content=恩, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160804/IMG57A2EF131ACE72300.jpg, createdBy=a2811610046, createdName=黄庆, createdTime=Thu Jun 04 16:57:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25936, encodeId=623625936ee, content=待研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d231626576, createdName=jjzouyan, createdTime=Thu Jun 04 15:59:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25924, encodeId=d20925924c4, content=的确有待研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f8011617873, createdName=bucm_ting, createdTime=Thu Jun 04 15:33:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25922, encodeId=422b2592285, content=有待深入研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e511627114, createdName=1dd7eb8am26(暂无匿称), createdTime=Thu Jun 04 15:28:00 CST 2015, time=2015-06-04, status=1, ipAttribution=)]
    2015-06-04 bucm_ting

    的确有待研究

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1723238, encodeId=d4581e23238b3, content=<a href='/topic/show?id=27a633e1015' target=_blank style='color:#2F92EE;'>#北大医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33710, encryptionId=27a633e1015, topicName=北大医院)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6da833418759, createdName=zhlpower, createdTime=Wed May 04 11:48:00 CST 2016, time=2016-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878107, encodeId=c3cd18e810732, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Thu Feb 25 21:48:00 CST 2016, time=2016-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1910127, encodeId=e42d191012ec0, content=<a href='/topic/show?id=0e4e43635a6' target=_blank style='color:#2F92EE;'>#大医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43635, encryptionId=0e4e43635a6, topicName=大医院)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Sat Jul 18 09:48:00 CST 2015, time=2015-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430527, encodeId=c583143052e61, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Jun 06 05:48:00 CST 2015, time=2015-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26001, encodeId=b5f826001e5, content=保佑, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7911626942, createdName=s312486, createdTime=Thu Jun 04 18:15:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25958, encodeId=64a6259581b, content=恩, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160804/IMG57A2EF131ACE72300.jpg, createdBy=a2811610046, createdName=黄庆, createdTime=Thu Jun 04 16:57:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25936, encodeId=623625936ee, content=待研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d231626576, createdName=jjzouyan, createdTime=Thu Jun 04 15:59:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25924, encodeId=d20925924c4, content=的确有待研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f8011617873, createdName=bucm_ting, createdTime=Thu Jun 04 15:33:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25922, encodeId=422b2592285, content=有待深入研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e511627114, createdName=1dd7eb8am26(暂无匿称), createdTime=Thu Jun 04 15:28:00 CST 2015, time=2015-06-04, status=1, ipAttribution=)]
    2015-06-04 1dd7eb8am26(暂无匿称)

    有待深入研究

    0