JACC:高敏心脏肌钙蛋白水平可预测心衰

2018-01-12 朱柳媛 中国循环杂志

临床上,心脏肌钙蛋白作为心肌受损的标志物,常被用来诊断急性心肌梗死。近期发表的一项Meta分析表明,高敏心脏肌钙蛋白水平与心衰也有很强的关联,包括肌钙蛋白T和肌钙蛋白I。


临床上,心脏肌钙蛋白作为心肌受损的标志物,常被用来诊断急性心肌梗死。近期发表的一项Meta分析表明,高敏心脏肌钙蛋白水平与心衰也有很强的关联,包括肌钙蛋白T和肌钙蛋白I。
 
研究者认为,高敏心脏肌钙蛋白有可能成为评估心衰的生物标志物。
 
分析显示,高敏心脏肌钙蛋白水平处于最高三分位的人出现心衰的风险是高敏心脏肌钙蛋白水平处于最低三分位者的2倍。
 
不论在男性还是在女性中(HR分别为2.29和2.18),也不论是高敏心脏肌钙蛋白T还是高敏心脏肌钙蛋白I(HR分别为2.11和2.09),均能得出类似的结果。
 
校正常用的心衰标志物B型利钠肽后,高敏心脏肌钙蛋白水平与心衰风险间的关系仍存在(HR=2.08)。
 
将高敏心脏肌钙蛋白水平加入到传统的心衰危险因素中后,对心衰的预测能力(C指数)可提高1%~3%。
 
该分析包括16项前瞻性研究,覆盖6.7万多例受试者,1年随访期间,共发生4165例心衰事件。
 
原始出处:

Jonathan D.W.Evans, Stephen J.H. Dobbin, Stephen J. Pettit, et al. High-Sensitivity Cardiac Troponin and New-Onset Heart Failure. JACC Heart Fail. January 2018

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    2018-01-16 hbwxf
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    2018-01-23 zwjnj2

    好好好好好学习天天向上

    0

  4. 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content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=80d11516357, createdName=139****0239, createdTime=Fri Jan 12 14:07:02 CST 2018, time=2018-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277849, encodeId=0b942e78493b, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=7dcf1938111, createdName=1e0e5a1fm42(暂无匿称), createdTime=Fri Jan 12 14:00:50 CST 2018, time=2018-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277837, encodeId=705a2e783736, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=353a2047758, createdName=137****9095, createdTime=Fri Jan 12 13:51:39 CST 2018, time=2018-01-12, status=1, ipAttribution=)]
    2018-01-17 虈亣靌

    认真学习.天天向上

    0

  5. 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  6. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277837, encodeId=705a2e783736, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=353a2047758, createdName=137****9095, createdTime=Fri Jan 12 13:51:39 CST 2018, time=2018-01-12, status=1, ipAttribution=)]
    2018-01-13 虈亣靌

    不错的文章值得推荐

    0

  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277837, encodeId=705a2e783736, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=353a2047758, createdName=137****9095, createdTime=Fri Jan 12 13:51:39 CST 2018, time=2018-01-12, status=1, ipAttribution=)]
    2018-01-12 三生有幸9135

    学习一下谢谢分享

    0

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277837, encodeId=705a2e783736, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=353a2047758, createdName=137****9095, createdTime=Fri Jan 12 13:51:39 CST 2018, time=2018-01-12, status=1, ipAttribution=)]
    2018-01-12 139****0239

    henhao

    0

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277837, encodeId=705a2e783736, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=353a2047758, createdName=137****9095, createdTime=Fri Jan 12 13:51:39 CST 2018, time=2018-01-12, status=1, ipAttribution=)]
    2018-01-12 1e0e5a1fm42(暂无匿称)

    henhao

    0

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    2018-01-12 137****9095

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