Hypertension:妊娠期高血压和慢性高血压孕妇血流动力学的预后价值

2020-06-16 MedSci原创 MedSci原创

这项研究的结果表明,SVR升高和CO低的高血压女性更容易发生先兆子痫。

近日,血管权威杂志Hypertension上发表了一篇研究文章,该研究旨在评估妊娠高血压或慢性高血压妇女的心血管评估对先兆子痫风险以及需要更密切的产前监测的预后价值。

这是一项于2015年1月至2018年5月期间在圣乔治医院就诊的妊娠高血压或慢性高血压孕妇中进行的前瞻性研究。研究人员使用无创超声心输出量监测仪来获取心输出量(CO)和全身血管阻力的心血管变量( SVR)和权重调整后的指标。该研究的主要结局是妊娠高血压或慢性高血压孕妇先兆子痫的发生时间。

诊断为妊娠高血压或慢性高血压的妇女(n=149),经比例风险分析发现诊断时平均动脉压(P=0.006)、非洲加勒比裔人群(P=0.045)和胎龄超过34周(P<0.001)与先兆子痫风险增加显著相关。与SVR和CO正常的女性相比,SVR高且CO正常的女性(风险比调整后为2.32 [95%CI为1.06-5.08];P=0.035)和SVR高而CO较低的女性(风险比为7.79 [95%CI为1.94-31.24];P=0.003)发生先兆子痫的风险明显更高。

这项研究的结果表明,SVR升高和CO低的高血压女性更容易发生先兆子痫。

原始出处:

Erkan Kalafat .et al.Prognostic Value of Maternal Cardiovascular Hemodynamics in Women With Gestational Hypertension and Chronic Hypertension in Pregnancy.Hypertension.2020.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.120.14982

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