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Clin oral invest：一种大新的鼠上颌磨牙脱出性脱位模型的组织学研究

2017-12-16 MedSci MedSci原创

脱位力牙齿损伤动物模型
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这项研究的目的是测试和检验大鼠上颌第一磨牙的新的脱出性脱位外伤模型。

这项研究的目的是测试和检验大鼠上颌第一磨牙的新的脱出性脱位外伤模型。

材料与方法：将45天龄的40只成年雄性大鼠（褐家鼠，Wistar；体重= 230-250g）分成八组（n = 5），对照组：动物不进行处理并饲养一天（GC1D）或3天（GC3D）以及实验组：动物施以1100cN，1300cN或1500cN的力并饲养1或3天后行安乐死（GT1100 / 1D，GT1100 / 3D，GT1300 / 1D ，GT1300 / 3D，GT1500 / 1D，GT1500 / 3D）。在实验组的动物中，创伤是由上颌第一磨牙的脱位力产生的。苏木精和伊红（HE）染色并行四微米系列切片。进行右上第一磨牙的描述性显微镜分析以及牙周膜急性和慢性炎症强度和血管变化以及活动和停止的根外吸收的半定量分析（评分1-4）。使用Fisher's精确检验的Freeman-Halton扩展比较组中得分的分布。P=5％。结果发现，随着脱位力的增加，牙周膜上的血管障碍（出血）变得更明显。

结论：这种新方法能够产生组织学变化，证明了其在该研究领域的安全应用。 1500cN的力会对牙周膜产生更大的损伤。

原始出处：

Luciana Artioli Costa， et al. Validation of a new experimental model of extrusive luxation on maxillary molars of rats： a histological study. Clinical oral investigations. 2017 December. doi：10.1007/s00784-017-2288-7

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    2018-05-05 爆笑小医

    #组织学#

    0

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    2018-09-11 xiangyuzhou971

    #EST#

    0

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    2018-09-07 小几洁

    #Oral#

    0

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    2017-12-18 ms1692212821629096

    #脱位#

    0

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    2017-12-18 12498474m35暂无昵称

    #磨牙#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1926226, encodeId=9af61926226bd, content=<a href='/topic/show?id=9238e767680' target=_blank style='color:#2F92EE;'>#组织学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77676, encryptionId=9238e767680, topicName=组织学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat May 05 20:22:00 CST 2018, time=2018-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050988, encodeId=f66720509885c, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Tue Sep 11 16:22:00 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2020305, encodeId=9dab202030547, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Fri Sep 07 08:22:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542502, encodeId=7a5b1542502f1, content=<a href='/topic/show?id=120f85233cb' target=_blank style='color:#2F92EE;'>#脱位#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85233, encryptionId=120f85233cb, topicName=脱位)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ebbe13414128, createdName=ms1692212821629096, createdTime=Mon Dec 18 03:22:00 CST 2017, time=2017-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576148, encodeId=c9cf15e6148cb, content=<a href='/topic/show?id=05a7e3816d7' target=_blank style='color:#2F92EE;'>#磨牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73816, encryptionId=05a7e3816d7, topicName=磨牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=570716304996, createdName=12498474m35暂无昵称, createdTime=Mon Dec 18 03:22:00 CST 2017, time=2017-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631128, encodeId=f7b9163112895, content=<a href='/topic/show?id=271b20090b0' target=_blank style='color:#2F92EE;'>#上颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20090, encryptionId=271b20090b0, topicName=上颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c07f21689347, createdName=hanhaisha2015, createdTime=Mon Dec 18 03:22:00 CST 2017, time=2017-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269849, encodeId=1993269849c0, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Dec 16 12:49:22 CST 2017, time=2017-12-16, status=1, ipAttribution=)]
    2017-12-18 hanhaisha2015

    #上颌#

    0

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    2017-12-16 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0