Thyroid：NSAIDs不能降低甲状腺癌风险

2015-11-09 Seven L 译 MedSci原创

有研究报道环氧合酶(COX-2)与某些癌症的生长转移息息相关，其中就包括甲状腺癌。也有研究者探究了COX-2抑制剂对临床前甲状腺癌模型的影响，发现其具有抗肿瘤作用。因此研究者进行了一项研究，探究使用非甾体类抗炎药 (NSAIDs)能否减少甲状腺癌的发生，以及探究甲状腺癌的危险因素或保护因素。该研究包含了3个大型的前瞻性研究，采集了参与者纳入研究前1年阿司匹林和其余NSAIDs的使用频率(未使用,

有研究报道环氧合酶(COX-2)与某些癌症的生长转移息息相关，其中就包括甲状腺癌。也有研究者探究了COX-2抑制剂对临床前甲状腺癌模型的影响，发现其具有抗肿瘤作用。因此研究者进行了一项研究，探究使用非甾体类抗炎药 (NSAIDs)能否减少甲状腺癌的发生，以及探究甲状腺癌的危险因素或保护因素。

该研究包含了3个大型的前瞻性研究，采集了参与者纳入研究前1年阿司匹林和其余NSAIDs的使用频率(未使用 ≤2/周， >2-6/周，≥7/周)，探究其与接下来甲状腺癌发生风险。

该研究共纳入388,577名患者，有 481例甲状腺癌发生。规律使用非阿司匹林NSAIDs的人群，并没有发现甲状腺风险的显著降低(HR 1.14, CI 0.84-1.55)，阿司匹林同样不能减少甲状腺癌风险(HR 1.06, CI 0.82-1.39)。

研究者发现以下因素会导致甲状腺癌风险增加：女性、BMI在30-35.99之间。以下因素起保护作用：吸烟现状、少量饮酒。

NSAIDs不管是不是阿司匹林，均不能减少甲状腺癌风险。女性和肥胖会增加该疾病风险，相反吸烟喝酒却起着保护作用。

原始出处：

Patel DT, Kitahara CM,et al.Thyroid Cancer and Nonsteroidal Antiinflammatory Drug Use: A Pooled Analysis of Patients Over 40 years of Age.Thyroid. 2015 Oct 1.

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#插入话题

插入图片

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2016-04-20 sjq027

#癌风险#

44 0
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2016-07-23 wjywjy

#AID#

50 0
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2016-04-04 d830372

#SAID#

46 0
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2016-01-27 doctording1

这篇文章有一定深度

130 0
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2016-01-27 doctording1

是一篇不错的文章

192 0
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2016-01-27 doctording1

值得进一步关注

165 0
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2016-01-27 doctording1

不错，赞一个

111 0
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2016-01-05 xyfg98

赞

91 0
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2016-01-05 三毛坨

Mm

89 0
[GetPortalCommentsPageByObjectIdResponse(id=2061492, encodeId=ff4c206149207, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Wed Apr 20 11:43:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2033830, encodeId=be3a20338303a, content=<a href='/topic/show?id=852b216824' target=_blank style='color:#2F92EE;'>#AID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2168, encryptionId=852b216824, topicName=AID)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1072181, createdName=wjywjy, createdTime=Sat Jul 23 10:43:00 CST 2016, time=2016-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793578, encodeId=07d61e9357834, content=<a href='/topic/show?id=0a3c158509b' target=_blank style='color:#2F92EE;'>#SAID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15850, encryptionId=0a3c158509b, topicName=SAID)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80a244, createdName=d830372, createdTime=Mon Apr 04 13:43:00 CST 2016, time=2016-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61485, encodeId=0aaa61485ca, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 23:21:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61486, encodeId=37f86148632, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=192, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 23:21:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61487, encodeId=e2506148eda, content=值得进一步关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 23:21:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61484, encodeId=8bdf61484bb, content=不错，赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 23:20:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52277, encodeId=e346522e72f, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Jan 05 22:43:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52068, encodeId=9abc5206868, content=Mm, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Tue Jan 05 13:02:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52067, encodeId=f0ed5206e22, content=I'm, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Tue Jan 05 13:02:00 CST 2016, time=2016-01-05, status=1, ipAttribution=)]
2016-01-05 三毛坨

I'm

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