Oncotarget:BEX2或是HBV感染肝细胞癌患者一个新型治疗靶点!

2017-08-16 Emma MedSci原创

肝细胞癌(hepatocellular carcinoma,HCC)是一种高死亡率的原发性肝癌,它是一种全球范围最常见的恶性肿瘤

肝细胞癌(hepatocellular carcinoma,HCC)是一种高死亡率的原发性肝癌,它是一种全球范围最常见的恶性肿瘤。原发性肝癌中通常HCC多见,而胆管细胞癌少见。慢性乙型肝炎病毒(HBV)感染是HCC的一个主要原因。乙型肝炎病毒X(HBx)是由HBV基因组编码的蛋白质之一,HBV基因组共有四个ORF,编码以下蛋白:Core蛋白和pre-core蛋白,Pol蛋白,X蛋白,以及S蛋白(L,M,S)。Core是核衣壳蛋白;Pre-core现在功能未知,它对病毒的复制不是必要的,但是可能与抑制宿主的免疫反应有关;X蛋白对病毒复制是重要的,还与肝癌的发生有关;S蛋白是病毒的包膜蛋白,与病毒进入细胞有关。

为了解HBx触发HCC的机制,从而为HCC提供治疗策略,研究人员调查了HBx在HCC中的作用。结果显示,BEX2在HCC发病机制中具有重要作用,其可能是HBV感染HCC患者的新型治疗靶点,新发现的HBx/BEX2/OPN信号盒涉及HBV诱导的HCC发病机制。

其中,BEX2(Brain-expressed X-linked 2)和OPN(Osteopontin)的表达在HBV转基因小鼠的肝组织和人类肝癌标本中升高,并且HBV感染HCC患者样本中BEX2和OPN呈正相关。与HBV阴性HCC标本相比,HBV阳性HCC标本中BEX2和OPN的蛋白水平均较高。HBx能够通过上调BEX2增强OPN表达,并且BEX2的消耗抑制了高表达HBx的HCC细胞的致瘤性。

原始出处:

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    2018-03-20 仁医06
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GetPortalCommentsPageByObjectIdResponse(id=234162, encodeId=dd1f23416214, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Wed Aug 16 20:47:46 CST 2017, time=2017-08-16, status=1, ipAttribution=)]
    2018-05-03 klivis
  5. [GetPortalCommentsPageByObjectIdResponse(id=1978536, encodeId=07ac19e85362c, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Thu May 31 12:46:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1780323, encodeId=4b511e8032359, content=<a href='/topic/show?id=b4ab336ebb' target=_blank style='color:#2F92EE;'>#BEX2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3367, encryptionId=b4ab336ebb, topicName=BEX2)], attachment=null, authenticateStatus=null, 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  6. [GetPortalCommentsPageByObjectIdResponse(id=1978536, encodeId=07ac19e85362c, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Thu May 31 12:46:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1780323, encodeId=4b511e8032359, content=<a href='/topic/show?id=b4ab336ebb' target=_blank style='color:#2F92EE;'>#BEX2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3367, encryptionId=b4ab336ebb, topicName=BEX2)], attachment=null, authenticateStatus=null, 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GetPortalCommentsPageByObjectIdResponse(id=234162, encodeId=dd1f23416214, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Wed Aug 16 20:47:46 CST 2017, time=2017-08-16, status=1, ipAttribution=)]
    2017-08-24 xjy02
  7. 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GetPortalCommentsPageByObjectIdResponse(id=234162, encodeId=dd1f23416214, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Wed Aug 16 20:47:46 CST 2017, time=2017-08-16, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1978536, encodeId=07ac19e85362c, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Thu May 31 12:46:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1780323, encodeId=4b511e8032359, content=<a href='/topic/show?id=b4ab336ebb' target=_blank style='color:#2F92EE;'>#BEX2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3367, encryptionId=b4ab336ebb, topicName=BEX2)], attachment=null, authenticateStatus=null, 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234407, encodeId=431423440ec6, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Thu Aug 17 11:34:19 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234242, encodeId=b61e2342427d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Thu Aug 17 00:55:27 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234162, encodeId=dd1f23416214, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Wed Aug 16 20:47:46 CST 2017, time=2017-08-16, status=1, ipAttribution=)]
    2017-08-17 清风拂面

    谢谢分享,学习了

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1978536, encodeId=07ac19e85362c, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Thu May 31 12:46:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1780323, encodeId=4b511e8032359, content=<a href='/topic/show?id=b4ab336ebb' target=_blank style='color:#2F92EE;'>#BEX2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3367, encryptionId=b4ab336ebb, topicName=BEX2)], attachment=null, authenticateStatus=null, 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GetPortalCommentsPageByObjectIdResponse(id=234162, encodeId=dd1f23416214, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Wed Aug 16 20:47:46 CST 2017, time=2017-08-16, status=1, ipAttribution=)]
    2017-08-17 yfjms

    学习了

    0

  10. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234407, encodeId=431423440ec6, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Thu Aug 17 11:34:19 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234242, encodeId=b61e2342427d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Thu Aug 17 00:55:27 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234162, encodeId=dd1f23416214, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Wed Aug 16 20:47:46 CST 2017, time=2017-08-16, status=1, ipAttribution=)]
    2017-08-16 changjiu

    学习了,谢谢

    0

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