JAHA:急性心梗伴房颤患者的支架类型选择

2017-09-12 xiangting MedSci原创

与BMS相比,符合抗凝指征的AF患者更有可能使用DES,即使是在中风和出血预测风险高的患者中。

已知除双重抗血小板治疗外,接受口服抗凝治疗的患者出血事件的风险很高; 因此,药物洗脱支架(DES)与裸金属支架(BMS)的选择对急性心梗(MI)的房颤(AF)患者可能具有重要意义。

从国家心血管资料登记ACTION(急性冠状动脉治疗和介入结局网络)中,确定了2008年至2014年间14 427例急性心梗并接受经皮冠脉介入治疗的AF患者。按中风风险(CHA2DS2-VASc)和出血风险ATRIA(心房颤动中的抗凝和危险因素)分析了DES使用的时间趋势和医院变异,支架类型。在有联网医疗保险数据(n = 2844)的患者中,多变量Cox回归模型用于比较复合结果(全因死亡率,卒中再入院或MI)风险,中风再入院,血运重建和1年内的大出血。8414例(58.9%)MI的AF患者中使用DES,从2008年的47.1%增加到2014年的67.9%,医院间差异很大。在高卒中风险(CHA2DS2-VASc≥2)和高出血风险(ATRIA≥4)的患者中,DES放置比BMS放置更为常见。虽然出院时不管支架类型如何,> 95%患者服用阿司匹林和P2Y12抑制剂,华法林在接受DES治疗的患者中比BMS少(31%vs.39%,P<0.001)。1年时DES或BMS患者的复合结果相似(22%vs 26%;调整风险比:0.88; 95%置信区间CI,0.76-1.03)。

伴AF的MI患者DES的使用随时间不断增多,但在不同医院间存在差异。与BMS相比,符合抗凝指征的AF患者更有可能使用DES,即使是在中风和出血预测风险高的患者中。

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    2017-09-12 184****9840

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