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SCI REP：虚弱是痴呆症发生的独立预测因素！

2017-11-16 xing.T MedSci原创

虚弱痴呆症预测因素
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由此可见，当评估老年人痴呆的危险因素时，应与认知功能一起对虚弱进行监测。

近日，Scientific reports杂志上发表了一篇研究文章，这项研究的目的是明确老年人虚弱是否与随后的痴呆症有关。

该研究共招募了8722名参与英国衰老纵向研究的老年人，每两年随访一次，直到这是受试者报告痴呆症、死亡或被右删失。研究人员采用由47个健康缺陷指标组成的虚弱指数来定义虚弱。为了检测认知功能是否会影响的虚弱与痴呆的关系，研究人员根据基础认知功能的最高四分位数和最低四分位数进行反复的分析。竞争风险回归和Cox比例风险模型被用来评估基础虚弱程度是否与痴呆事件有关。

在进行协变量调整后，与非虚弱参与者相比，虚弱前期参与者（风险比为1.51，95%可信区间为1.12-2.02）和虚弱的参与者（风险比为1.73，95%可信区间为1.22-2.43）患痴呆症的风险更高。研究人员发现整体认知功能在第2-4个四分位数范围的成人中虚弱与痴呆发生之间存在显著的相关性（风险比为3.48 95%可信区间为1.98-6.12），但在整体认知功能在最低四分位数范围的成人中则没有相关性（风险比为1.13 95%可信区间为0.74-1.71）。

由此可见，当评估老年人痴呆的危险因素时，应与认知功能一起对虚弱进行监测。

原始出处：

Nina T. Rogers,et al. Frailty is an independent predictor of incident dementia: Evidence from the English Longitudinal Study of Ageing.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-16104-y

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    2018-03-19 owlhealth

    不错耶.学习了

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    2018-08-08 Boyinsh

    #痴呆症#

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    2017-11-19 sunfeifeiyang

    虚弱致痴呆

    0

  4. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Thu Nov 16 20:11:58 CST 2017, time=2017-11-16, status=1, ipAttribution=)]
    2017-11-18 朱睿睿

    #预测因素#

    0

  5. 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    2017-11-17 三生有幸9135

    学习一下谢谢分享

    0

  6. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Thu Nov 16 20:11:58 CST 2017, time=2017-11-16, status=1, ipAttribution=)]
    2017-11-17 sunfeifeiyang

    虚弱致痴呆

    0

  7. 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createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Nov 16 21:32:36 CST 2017, time=2017-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=261793, encodeId=2447261e93ef, content=谢谢分享.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=13, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Thu Nov 16 20:28:56 CST 2017, time=2017-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=261784, encodeId=1ea5261e84b6, content=谢谢分享. , beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Thu Nov 16 20:11:58 CST 2017, time=2017-11-16, status=1, ipAttribution=)]
    2017-11-17 swfzhanggui

    加强锻炼.增强体质

    0

  8. 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createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Nov 16 21:32:36 CST 2017, time=2017-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=261793, encodeId=2447261e93ef, content=谢谢分享.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=13, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Thu Nov 16 20:28:56 CST 2017, time=2017-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=261784, encodeId=1ea5261e84b6, content=谢谢分享. , beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Thu Nov 16 20:11:58 CST 2017, time=2017-11-16, status=1, ipAttribution=)]
    2017-11-16 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

  9. 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10:45:00 CST 2017, time=2017-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262069, encodeId=4bb5262069db, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Fri Nov 17 21:08:41 CST 2017, time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=261980, encodeId=7348261980d1, content=虚弱致痴呆, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Thu Nov 16 20:11:58 CST 2017, time=2017-11-16, status=1, ipAttribution=)]
    2017-11-16 清风拂面

    谢谢分享.学习受益匪浅

    0

  10. 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10:45:00 CST 2017, time=2017-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262069, encodeId=4bb5262069db, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Fri Nov 17 21:08:41 CST 2017, time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=261980, encodeId=7348261980d1, content=虚弱致痴呆, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, 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createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Nov 16 21:32:36 CST 2017, time=2017-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=261793, encodeId=2447261e93ef, content=谢谢分享.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=13, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Thu Nov 16 20:28:56 CST 2017, time=2017-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=261784, encodeId=1ea5261e84b6, content=谢谢分享. , beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Thu Nov 16 20:11:58 CST 2017, time=2017-11-16, status=1, ipAttribution=)]
    2017-11-16 doctorJiangchao

    谢谢分享.

    0

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虚弱是一种老年性的"综合征"，对经导管主动脉瓣置换术（TAVR）或经外科主动脉瓣置换术（SAVR）后的恢复存在潜在的影响。然而，受到对虚弱量化的限制，临床上很难开展相关研究。近日，在国际心血管权威杂志JACC上发表了一篇旨在比较7种不同的虚弱测量尺度来预测TAVR或SAVR术后预后不良结局的临床研究。本研究纳入了2012年至2016年来自3个国家14个研究中心的TAVR和SAVR术后的老年患者，并

JAMA Surg：患者虚弱与门诊术后并发症

研究认为，对于普通门诊手术，虚弱与围手术期发病率增加有关，与年龄、麻醉类型和其他合并症无关。外科医生选择门诊手术时机时应该考虑到患者的虚弱性而不是年龄

JACC：老年人主动脉瓣置换术后的虚弱状况评估

虚弱是TAVR和SAVR后死亡和残疾的危险因素。

CA Cancer J Clin：虚弱与癌症

越来越多的人认识到虚弱是影响保健和健康结局中最重要的问题之一，而且在接受手术、化疗和放疗的癌症患者中尤为重要。由于癌症再加上癌症的各种疗法不断消耗机体，加大了虚弱的发生率，尤其是老年癌症患者。据估计，超过一半的老年癌症患者处于虚弱或虚弱前期。虚弱并不能简单定义，简言之，虚弱是一种极易受压力影响的状态，可导致不良的健康结局。事实上，虚弱是一个复杂的、多层面的、周期性的生理储备减少的状态，导致患者复原

CMAJ:“久坐”风险知多少？

根据CMAJ（加拿大医学协会杂志）发表的一项新研究，久坐行为增加因身体虚弱，失眠时间而死亡的风险，例如，坐下的时间，增加身体虚弱和不活跃的中年和老年人的死亡风险，但不会增加不活跃的非虚弱者的风险。

CA Cancer J Clin：虚弱对肿瘤患者的治疗影响

医学的目的从来都是救治患者、而不仅仅是治病，所以就要求临床医生要多从患者的角度来考虑诸多问题。而虚弱的定义一直以来都是一个非常模糊的状态，基本只能靠主观定义，那么就导致对患者治疗的疗效、并发症发生几率、近期及远期生存无法进行准确评估。本文就虚弱与肿瘤患者的治疗疗效、治疗相关副作用、无进展生存期、总生存期之间做一简要综述。