JACC:肾素-血管紧张素抑制剂对TAVR术后患者有心血管保护作用

2019-08-05 不详 MedSci原创

许多研究证实了经导管主动脉瓣置换术(TAVR)对主动脉瓣狭窄患者的益处,但是持续性纤维化和心肌肥厚的存在会使患者预后更差。本研究的目的旨在评估肾素-血管紧张素系统(RAS)抑制剂对TAVR术后左室重塑和临床预后的影响。本研究纳入分析了2785名接受TAVR治疗的严重主动脉瓣狭窄患者,接受RAS抑制剂治疗的患者(n=1622)虽然外科手术风险评分相似,但是心血管危险因素、冠心病和心梗风险更高。经过基

许多研究证实了经导管主动脉瓣置换术(TAVR)对主动脉瓣狭窄患者的益处,但是持续性纤维化和心肌肥厚的存在会使患者预后更差。本研究的目的旨在评估肾素-血管紧张素系统(RAS)抑制剂对TAVR术后左室重塑和临床预后的影响。

本研究纳入分析了2785名接受TAVR治疗的严重主动脉瓣狭窄患者,接受RAS抑制剂治疗的患者(n=1622)虽然外科手术风险评分相似,但是心血管危险因素、冠心病和心梗风险更高。经过基线差异因素调整分析后发现,与没有接受RAS抑制剂患者相比,接受了RAS抑制剂治疗的患者左室体积和肥厚程度明显更少,3年随访的心血管死亡率也更低(OR:0.59; 95% cl: 0.41-0.87; p = 0.007)。另外,RAS抑制剂还可以减少新发房颤、脑血管和再住院率。

研究结果显示,TAVR术后患者服用RAS抑制剂可以降低心血管死亡率,起到心血管全面保护的作用。

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    2020-05-12 hbwxf
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    2020-01-09 jklm09
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