英国授权开展全球针对肾脏移植免疫排斥反应的CAR-Treg细胞疗法临床研究

2019-11-22 不详 MedSci原创

英国药品保健产品监管局(MHRA)已授权Sangamo Therapeutics开展首个嵌合抗原受体调节性T细胞(CAR-Treg)疗法TX200的临床试验STEADFAST。TX200正在研究用于预防HLA-A2错配肾脏移植治疗终末期肾脏疾病(ESRD)后免疫介导的排斥反应。

英国药品保健产品监管局(MHRA)已授权Sangamo Therapeutics开展首个嵌合抗原受体调节性T细胞(CAR-Treg)疗法TX200的临床试验STEADFAST。TX200正在研究用于预防HLA-A2错配肾脏移植治疗终末期肾脏疾病(ESRD)后免疫介导的排斥反应。

研究与开发负责人Adrian Woolfson说:"我们相信TX200实验计划对于扩大我们对CAR-Treg细胞的安全性和作用机制及其在临床应用的了解将是无价的。这种针对HLA-A2错配肾移植的创新性和个性化细胞疗法,旨在帮助局部调节人体的免疫系统,以促进接受免疫错配的供体器官。"

"除了移植,我们计划探索CAR-Tregs在一系列自身免疫和炎性疾病中的潜力。"

TX200是一种针对HLA-A2的自体(从患者收集的细胞)CAR-Treg细胞疗法。收集患者的调节性T细胞(Tregs),并将嵌合抗原受体(CAR)设计与人白细胞抗原HLA-A2蛋白结合。

HLA分子中的供体/受体错配是器官移植不相容的主要原因,可能最终导致免疫介导的移植器官排斥。受体的免疫系统可以识别这种HLA-A2错配,并可能攻击携带HLA-A2蛋白的新肾脏,从而导致移植排斥。TX200 HLA-A2 CAR-Treg细胞被设计利用Treg抑制移植肾的免疫反应。

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    2020-07-13 仁者大医
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  5. 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createdTime=Sun Nov 24 05:52:00 CST 2019, time=2019-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576976, encodeId=612c15e697674, content=<a href='/topic/show?id=201f29042ff' target=_blank style='color:#2F92EE;'>#免疫排斥#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29042, encryptionId=201f29042ff, topicName=免疫排斥)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b216353032, createdName=ms6829001416292975, createdTime=Sun Nov 24 05:52:00 CST 2019, time=2019-11-24, status=1, ipAttribution=)]
  6. 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  7. 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  8. 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  9. 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  10. 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