Lancet Neurol:中枢神经系统真菌感染诊断和治疗的新近进展

2018-04-08 吴星 环球医学

2018年4月,发表于《Lancet Neurol》上的一项综述,描述了中枢神经系统(CNS)真菌感染诊断和治疗的最新进展。

2018年4月,发表于《Lancet Neurol》上的一项综述,描述了中枢神经系统(CNS)真菌感染诊断和治疗的最新进展

CNS真菌感染的治疗具有挑战性,其最佳管理方案需要了解其流行病学、宿主特征、诊断标准及治疗选择等相关知识。曲霉属和隐球菌属为主要的CMS真菌感染菌属。这些真菌大多是普遍存在的,但是一些具有限制性分布的特征。CNS真菌感染通常起源于CNS外的原发部位(如真菌性肺炎)或接种后发生(如侵入性操作)。多数这些感染患者具有免疫缺陷,但是免疫功能正常的个体也会通过重度暴露而感染。感染真菌可分为霉菌、酵母和双态性真菌。随着新诊断方法和新型抗真菌药物的引入后,真菌感染的诊断和治疗已经取得了重大进展,但是CNS真菌感染由于诊断延迟、药物渗透性受损、抗真菌药物耐药及免疫功能恢复不足等原因而常常致命。为了改善结局,将来的研究应该推进诊断方法(如分子检测和真菌鉴定),开发能够加强直接针对CNS有效性的抗真菌化合物,并进一步研究关键的宿主防御机制。

原始出处

Schwartz S, Kontoyiannis DP, Harrison T, et al. Advances in the diagnosis and treatment of fungal infections of the CNS. Lancet Neurol. 2018 Apr;17(4):362-372. doi: 10.1016/S1474-4422(18)30030-9.

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    2018-08-19 yinhl1978
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    2018-11-28 howi
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    2018-04-10 zhaojie88
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    2018-04-09 yfjms

    学习

    0

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