J Appl Oral Sci:白色念珠菌在糖尿病患者中更为常见,毒力更高

2017-07-18 MedSci MedSci原创

本研究旨在探究糖尿病及糖耐量正常的患者中从牙周牙髓病变中念珠菌非检测率,并在不同的外界环境中检测真菌的毒力。采用病例对照研究设计,共纳入了15名2型糖尿病患者(G1)和15例非糖尿病的牙周牙髓病患者(G2)。采集根管及牙周袋样品,随后通过聚合酶链反应(PCR)鉴定CHROMagar念珠菌显,并进行毒力试验。结果,从糖尿病和糖耐量正常的患者中收集的60个样本中,白色念珠菌的检测率分别为79.2%和2

本研究旨在探究糖尿病及糖耐量正常的患者中从牙周牙髓病变中念珠菌非检测率,并在不同的外界环境中检测真菌的毒力。

采用病例对照研究设计,共纳入了15名2型糖尿病患者(G1)和15例非糖尿病的牙周牙髓病患者(G2)。采集根管及牙周袋样品,随后通过聚合酶链反应(PCR)鉴定CHROMagar念珠菌显,并进行毒力试验。

结果,从糖尿病和糖耐量正常的患者中收集的60个样本中,白色念珠菌的检测率分别为79.2%和20.8%。从牙周袋收集的30个标本中,13个样本白色念珠菌培养阳性,其中77%为G1,23%为G2。来自根管的11个阳性标本中,82%为G1,18%为G2。蛋白酶的存在代表沉淀区PZ<0.63, G1 为100%,G2 为72%,两组均在厌氧条件下。G1菌株的疏水性,16.4%为低, 19.3%为中度,64.3%为高疏水性。G2菌株的疏水性,42.2%低,39.8%中度,18%高度疏水性。在厌氧条件下,G1表现出15.2%低、12.8%中度、72%高疏水性;G2为33.6%低,28.8%中度,37.6%高疏水性。G1和G2之间阳性培养数差异有统计学意义(p<0.05),G1占优势。除溶血外,所有毒力因子差异有统计学意义(P=0.001)。

总而言之,该研究表明,白色念珠菌在糖尿病患者中更为常见,毒力较高。

原始出处:

Cinthya Cristina GOMES, Ludmila Silva GUIMARÃES, et al., Investigations of the prevalence and virulence of Candida albicans in periodontal and endodontic lesions in diabetic and normoglycemic patients. J Appl Oral Sci. 2017 May-Jun; 25(3): 274–281. doi: 10.1590/1678-7757-2016-0432
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    2018-05-02 小几洁
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    2017-07-19 李东泽

    很好,不错,以后会多学习

    0

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义齿相关性口炎是一种常见的念珠菌感染,可能会引起疼痛或其他部位感染源。由于聚(甲基丙烯酸甲酯)(PMMA)仍然是用于制作义齿的主要材料,本研究的目的是通过使用原子力显微镜(AFM)单细胞力光谱学(SCFS)技术来评估白色念珠菌细胞对PMMA表面的粘附作用。

JAMA Ophthalmol:新英格兰静脉吸毒者内源性真菌性眼内炎的暴发

静脉吸毒(IVDA)是内源性真菌性眼内炎的已知风险因子(EFE),其真菌生物体通过静脉而血行传播至眼,导致眼内真菌感染。据报道自2014年以来,随着海洛因相关死亡率的上升,新英格兰的毒品行为猖獗,由毒品引起的真菌性眼内炎的疾病风险也在大幅增加。