肿瘤科

订阅

MedSci主页 / 所有栏目 / 肿瘤科

Aging：免疫评分和免疫微环境相关基因对肝细胞癌的预后价值

2020-05-26 MedSci原创 MedSci原创

免疫微环境
关注

掌握肿瘤免疫微环境的特征对提高免疫治疗效果至关重要。

掌握肿瘤免疫微环境的特征对提高免疫治疗效果至关重要。

 

在这项研究中，研究人员计算了371例患者的免疫和基质评分，以定量分析肝细胞癌（HCC）肿瘤微环境中的免疫和基质细胞浸润。分析了加权基因共表达网络分析和蛋白质-蛋白质相互作用网络，以鉴定与免疫微环境相关的基因。

 

结果显示，免疫评分高的患者4年无复发率更高。TP53，CTNNB1和AXIN1突变随免疫评分而显著变化。在与免疫评分相关的模块分析中，有关基因和基因组途径的京都百科全书以及基因本体术语与免疫过程，肿瘤发生和转移密切相关。确定了十二个新的免疫微环境相关基因，并与七个免疫检查点基因明显正相关。在预后分析中，有11个与免疫微环境相关的基因表现出高表达，其中9个在GSE62232数据集中得到验证，并与良好的预后显着相关。

 

我们的发现表明，计算免疫评分和基质评分可以帮助确定肿瘤的微环境中的肿瘤纯度和免疫细胞浸润。在这项研究中确定的九个免疫微环境相关基因有潜力作为肝癌的预后标志物。

 

原始出处：

 

Peng-Lei Ge, Shi-Fang Li, et al., Prognostic Values of Immune Scores and Immune Microenvironment-Related Genes for Hepatocellular Carcinoma. Aging (Albany NY). 2020 Mar 25;12(6):5479-5499. doi: 10.18632/aging.102971. Epub 2020 Mar 25.

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1863501, encodeId=93df1863501f4, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Fri Apr 16 10:10:42 CST 2021, time=2021-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029330, encodeId=a7d42029330dd, content=<a href='/topic/show?id=9c52e253016' target=_blank style='color:#2F92EE;'>#相关基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72530, encryptionId=9c52e253016, topicName=相关基因)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKCRibWHQArPHdSkqP90U1HwwqlGeU7BUgzY240D3v2ibBDJ09ybkGkwOjxz7qRmngZaGlK1taX6hfA/132, createdBy=2e772500094, createdName=小华子, createdTime=Wed Dec 09 13:10:42 CST 2020, time=2020-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978988, encodeId=bfe819e898879, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Tue Oct 27 11:10:42 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385237, encodeId=fe28138523e73, content=<a href='/topic/show?id=dc121001e22d' target=_blank style='color:#2F92EE;'>#预后价值#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100172, encryptionId=dc121001e22d, topicName=预后价值)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=70fe497, createdName=paperyu, createdTime=Thu May 28 05:10:42 CST 2020, time=2020-05-28, status=1, ipAttribution=)]
    2021-04-16 xjy02

    #肝细胞#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1863501, encodeId=93df1863501f4, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Fri Apr 16 10:10:42 CST 2021, time=2021-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029330, encodeId=a7d42029330dd, content=<a href='/topic/show?id=9c52e253016' target=_blank style='color:#2F92EE;'>#相关基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72530, encryptionId=9c52e253016, topicName=相关基因)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKCRibWHQArPHdSkqP90U1HwwqlGeU7BUgzY240D3v2ibBDJ09ybkGkwOjxz7qRmngZaGlK1taX6hfA/132, createdBy=2e772500094, createdName=小华子, createdTime=Wed Dec 09 13:10:42 CST 2020, time=2020-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978988, encodeId=bfe819e898879, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Tue Oct 27 11:10:42 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385237, encodeId=fe28138523e73, content=<a href='/topic/show?id=dc121001e22d' target=_blank style='color:#2F92EE;'>#预后价值#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100172, encryptionId=dc121001e22d, topicName=预后价值)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=70fe497, createdName=paperyu, createdTime=Thu May 28 05:10:42 CST 2020, time=2020-05-28, status=1, ipAttribution=)]
    2020-12-09 小华子

    #相关基因#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1863501, encodeId=93df1863501f4, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Fri Apr 16 10:10:42 CST 2021, time=2021-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029330, encodeId=a7d42029330dd, content=<a href='/topic/show?id=9c52e253016' target=_blank style='color:#2F92EE;'>#相关基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72530, encryptionId=9c52e253016, topicName=相关基因)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKCRibWHQArPHdSkqP90U1HwwqlGeU7BUgzY240D3v2ibBDJ09ybkGkwOjxz7qRmngZaGlK1taX6hfA/132, createdBy=2e772500094, createdName=小华子, createdTime=Wed Dec 09 13:10:42 CST 2020, time=2020-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978988, encodeId=bfe819e898879, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Tue Oct 27 11:10:42 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385237, encodeId=fe28138523e73, content=<a href='/topic/show?id=dc121001e22d' target=_blank style='color:#2F92EE;'>#预后价值#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100172, encryptionId=dc121001e22d, topicName=预后价值)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=70fe497, createdName=paperyu, createdTime=Thu May 28 05:10:42 CST 2020, time=2020-05-28, status=1, ipAttribution=)]
    2020-10-27 qingting

    #细胞癌#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1863501, encodeId=93df1863501f4, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Fri Apr 16 10:10:42 CST 2021, time=2021-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029330, encodeId=a7d42029330dd, content=<a href='/topic/show?id=9c52e253016' target=_blank style='color:#2F92EE;'>#相关基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72530, encryptionId=9c52e253016, topicName=相关基因)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKCRibWHQArPHdSkqP90U1HwwqlGeU7BUgzY240D3v2ibBDJ09ybkGkwOjxz7qRmngZaGlK1taX6hfA/132, createdBy=2e772500094, createdName=小华子, createdTime=Wed Dec 09 13:10:42 CST 2020, time=2020-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978988, encodeId=bfe819e898879, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Tue Oct 27 11:10:42 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385237, encodeId=fe28138523e73, content=<a href='/topic/show?id=dc121001e22d' target=_blank style='color:#2F92EE;'>#预后价值#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100172, encryptionId=dc121001e22d, topicName=预后价值)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=70fe497, createdName=paperyu, createdTime=Thu May 28 05:10:42 CST 2020, time=2020-05-28, status=1, ipAttribution=)]
    2020-05-28 paperyu

    #预后价值#

    0

相关资讯

CD73在肿瘤免疫微环境中的研究进展

肿瘤的发生、发展和转移是涉及肿瘤细胞、免疫微环境、细胞因子等多种因素参与并相互影响的复杂过程。研究发现，CD73-腺苷代谢通路在肿瘤免疫逃逸中扮演着重要角色[1]。CD73是胞外5'-核苷酸酶，由糖基磷脂酰肌醇（GPI）锚定于细胞膜外表面，CD73分子在多种肿瘤组织中呈现高表达，不仅参与嘌呤核苷酸的代谢和补救合成途径，而且作为一种重要的免疫信号负调控分子，通过催化免疫抑制性介质腺苷（ADO

Cell reports: ATR突变通过调节免疫微环境促进黑色素瘤的生长

黑色素瘤发生发展过程中不断累积UV照射诱导的突变。尽管基因组研究已经鉴定了一些假定的黑色素瘤驱动突变，开发了诸如MAP激酶抑制剂等诱导肿瘤消退的药剂，其他UV诱导的突变和肿瘤异质性作为一个整体如何调节肿瘤生长仍然不清楚。

CLIN CANCER RES：免疫微环境通过巨噬细胞分泌的IL-6诱导结直肠癌耐药

肿瘤相关巨噬细胞（TAM）与肿瘤患者不良预后有关。但TAM在结直肠癌中的作用一直存在争议。CLIN CANCER RES近期发表了一篇文章，研究结直肠癌中TAM的功能、机制和临床意义。

Blood：十二指肠型滤泡性淋巴瘤

中心点：DTFL的免疫图谱与淋巴结型FL高度相关，但携带较少的KMT2D多发/等位基因突变。DTFL的免疫微环境与淋巴结型FL的显着不同，富集慢性炎症基因特征。摘要：十二指肠型滤泡性淋巴瘤（DTFL）是一种罕见的高度惰性的滤泡性淋巴瘤（FL）。其形态学和免疫表型与典型FL无明显区别，其特征是小肠黏膜限制性受损，无肠外表现。目前，造成其临床特征如此独特的分子机制基本尚不明确。Johannes C.

Oncotarget：肿瘤免疫微环境因子竟然与食管鳞状细胞癌患者生存情况有关！

食管鳞状细胞癌（ESCC）是与预后不良相关的最常见的食管癌，需要额外治疗策略的实施来优化ESCC的治疗。

CLIN CANCER RES：肝细胞癌免疫微环境特点

肝细胞癌是一种恶性肿瘤，通常由慢性肝脏疾病或肝硬化发展而来。世界范围内肝细胞癌是肿瘤相关死亡的第二大因素。肝细胞癌的主要风险因素包括肝炎肝硬化，酒精性肝疾病和非酒精性脂肪肝。肝细胞癌可能对免疫治疗存在反应。CLIN CANCER RES近期发表了一篇文章，研究肝细胞癌的免疫微环境特点。