Chest:系统性硬化症伴肺动脉高压患者的长期结局!

2018-05-21 xing.T MedSci原创

由此可见,PHAROS的总生存率高于其他SSc-PAH队列。PAH占死亡人数的一半以上,主要发生在PAH诊断后的前几年内。对于早期PAH相关性死亡风险最高的患者,优化治疗至关重要。

肺动脉高压(PAH)是系统性硬化症(SSc)患者死亡的主要原因。近日,呼吸领域权威杂志chest上发表了一篇研究文章,该研究的目的是评估SSc-PAH患者的长期预后。

硬皮病的肺动脉高压评估和结局识别(PHAROS)研究是基于右心导管检查(RHC)的高危肺动脉高压患者的前瞻性研究。研究人员分析了世界卫生组织I组PAH患者。为总体队列和死于PAH的人群生成Kaplan-Meier生存曲线,多变量cox回归模型确定了死亡的预测因子。

160例SSc-PAH患者在1年、3年、5年和8年的生存率分别为95%、75%、63%和49%。PAH占所有死亡人数的52%。当限定于PAH引起的死亡时,相应的生存率分别为97%、83%、76%和76%,其中93%的PAH相关死亡发生在诊断后4年内。男性(HR为3.11,95%CI为1.38-6.98)、弥漫性疾病(HR为2.12,95%CI为1.13-3.93)、超声心动图测得的收缩期肺动脉压(PAP)(HR为1.06,95%CI为1.01-1.11),在RHC上的PAP(HR为1.03,95%CI为1001-1.07)、6分钟步行距离(HR为0.92,95%CI为0.86-0.99)和一氧化碳弥散量(HR为0.65,95%CI为0.46-0.92)显着影响多因素分析的生存率。

由此可见,PHAROS的总生存率高于其他SSc-PAH队列。PAH占死亡人数的一半以上,主要发生在PAH诊断后的前几年内。对于早期PAH相关性死亡风险最高的患者,优化治疗至关重要。

原始出处:

Kathleen D. Kolstad,et al.Long-term Outcomes in Systemic Sclerosis Associated Pulmonary Arterial Hypertension from the Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma Registry (PHAROS).chest.2018. https://doi.org/10.1016/j.chest.2018.05.002

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    2019-03-31 Smile2680
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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050797, encodeId=f7fc1050e973b, content=肺动脉高压表面是罕见病,事实上临床上并不少见,治疗药物虽然有一些,但是整体仍然不理解,可能未来需要采用综合治疗措施。, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Mon May 21 20:22:00 CST 2018, time=2018-05-21, status=1, ipAttribution=)]
  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050797, encodeId=f7fc1050e973b, content=肺动脉高压表面是罕见病,事实上临床上并不少见,治疗药物虽然有一些,但是整体仍然不理解,可能未来需要采用综合治疗措施。, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Mon May 21 20:22:00 CST 2018, time=2018-05-21, status=1, ipAttribution=)]
    2018-05-25 wxl882001

    学习一下

    0

  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050797, encodeId=f7fc1050e973b, content=肺动脉高压表面是罕见病,事实上临床上并不少见,治疗药物虽然有一些,但是整体仍然不理解,可能未来需要采用综合治疗措施。, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Mon May 21 20:22:00 CST 2018, time=2018-05-21, status=1, ipAttribution=)]
    2018-05-21 明天jing

    肺动脉高压表面是罕见病,事实上临床上并不少见,治疗药物虽然有一些,但是整体仍然不理解,可能未来需要采用综合治疗措施。

    0

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