BMJ研究新闻:心梗后未能及时接受治疗可增加心肌损伤的程度

2016-01-03 MedSci MedSci原创

据发表于JACC Cardiovasc Interv的一项新的研究显示,患者心梗后未能及时识别心梗的症状并延迟寻求医疗帮助可加重其心肌的损伤。

据发表于JACC Cardiovasc Interv的一项新的研究显示,患者心梗后未能及时识别心梗的症状并延迟寻求医疗帮助可加重其心肌的损伤。

该研究表明,减少心梗患者到医院就诊的时间可降低患者的心肌损伤程度,这可进一步提高公众关于及时就诊的意识。

研究人员回顾了2056例经皮冠状动脉介入治疗(PCI)的ST段抬高型心肌梗死(STEMI)患者的病历记录。根据患者从症状出现到接受PCI成功治疗的时间(SBT,≤2小时;2-4小时;或>4小时)将患者分为三组,研究人员对比了这三组患者治疗后的心肌灌注水平。此外,研究人员还根据患者第一次到达医院到接受PCI治疗的时间分析了患者的数据。

分析结果显示,症状出现到接受球囊扩张治疗的时间越长,患者心功能受损的程度越重,评为无微血管灌注(心肌呈色分级1 / 0)以及ST段抬高受损分辨率(<30%)。从症状出现到接受治疗的时间长于4小时的患者术后出现心肌灌注受损的可能是从症状出现到接受治疗的时间≤2小时的患者的2倍。

研究人员写道,“我们观察到,SBT与PCI治疗后心肌灌注受损的可能之间存在一种“时间依赖性”的关系。

“从症状出现到接受治疗的时间在2小时之内的患者最不容易出现心肌灌注受损。”

心梗症状出现到接受球囊扩张治疗与心肌灌注之间的关系独立于与患者临床特征,且可见于低和高临床风险因素的患者中。

患者进入医院到接受PCI治疗的时间较短与更好的心肌灌注有关,但是对于那些出现心梗症状到接受PCI治疗的时间长于2小时的患者则不会出现较好的心肌灌注效果。

该研究共同作者Roxana Mehran说道,“该研究强调了重新考虑心梗患者从入院到接受PCI治疗的时间作为的一个性能指标的重要性,以及检查一个更广泛的系统延迟指标(如就诊接受治疗的时间以及总的缺血时间)的重要性。”

原始出处:

Susan Mayor. Delay in seeking help after myocardial infarction increases cardiac damage, study shows. BMJ 2015; 351 doi: http://dx.doi.org/10.1136/bmj.h6992.


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    2016-10-23 gaoxiaoe
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    2016-07-16 lfyang
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