SCIENCE：秦川团队发现SARS-CoV-2感染过的猕猴对二次感染有抵抗力

2020-07-12 MedSci原创 MedSci原创

侠胆医心

上海中山医院医生/ 主任医师

2019年冠状病毒病(COVID-19)是由冠状病毒2型(SARS-CoV-2)感染引起的严重急性呼吸道综合征，现已成为全球流行病。人们目前仍不清楚治愈的患者是否有再感染的风险。

2019年冠状病毒病(COVID-19)是由冠状病毒2型(SARS-CoV-2)感染引起的严重急性呼吸道综合征，现已成为全球流行病。人们目前仍不清楚治愈的患者是否有再感染的风险。

最近，秦川等研究人员建立了一个SARS-CoV-2感染的猕猴模型，其特点是间质性肺炎和主要在呼吸道和胃肠道的全身病毒传播。

在初次SARS-CoV-2感染的早期恢复阶段，用相同的SARS-CoV-2菌株重新感染的猕猴没有出现可检测到的病毒播散、病毒疾病的临床表现或组织病理学变化。

比较初次感染和病毒再挑战时的体液免疫和细胞免疫，研究人员发现中和抗体和免疫反应明显增强。

因此，该结果表明，原发性SARS-CoV-2暴露可保护猕猴免受随后的再感染。

《科学》首发动物实验结果：京企产新冠疫苗安全有效

Science：中国研发的新型冠状病毒灭活疫苗在恒河猴模型中安全有效

原始出处：

Wei Deng et al. Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques, SCIENCE (2020). DOI: 10.1126/science.abc5343

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评论区 (7)

#插入话题

插入图片

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2020-07-19 hukaixun

#SARS-CoV#

26 0
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2020-12-19 huagfeg

#二次感染#

24 0
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2020-08-15 Dolly66

有效果吗

77 0
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2020-07-14 小刀医生

#SARS#

20 0
[GetPortalCommentsPageByObjectIdResponse(id=1937934, encodeId=5e73193e93402, content=<a href='/topic/show?id=02de15902d3' target=_blank style='color:#2F92EE;'>#SARS-CoV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15902, encryptionId=02de15902d3, topicName=SARS-CoV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sun Jul 19 10:44:22 CST 2020, time=2020-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1993696, encodeId=70a2199369605, content=<a href='/topic/show?id=00502394328' target=_blank style='color:#2F92EE;'>#二次感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23943, encryptionId=00502394328, topicName=二次感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1dbc2500219, createdName=huagfeg, createdTime=Sat Dec 19 10:44:22 CST 2020, time=2020-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809045, encodeId=5dc88090452a, content=有效果吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200815/bc57614038034f80b4a141a3adf50037/ec920323764b4e5f8406b52ac100df3f.jpg, createdBy=f48e5151422, createdName=Dolly66, createdTime=Sat Aug 15 03:19:18 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321200, encodeId=cecc132120057, content=<a href='/topic/show?id=ac0d159007f' target=_blank style='color:#2F92EE;'>#SARS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15900, encryptionId=ac0d159007f, topicName=SARS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8306486, createdName=小刀医生, createdTime=Tue Jul 14 01:44:22 CST 2020, time=2020-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376127, encodeId=851913e61275b, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Tue Jul 14 01:44:22 CST 2020, time=2020-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616320, encodeId=abef16163201a, content=<a href='/topic/show?id=6f855608584' target=_blank style='color:#2F92EE;'>#抵抗力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56085, encryptionId=6f855608584, topicName=抵抗力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47f119741723, createdName=12498b37m78暂无昵称, createdTime=Tue Jul 14 01:44:22 CST 2020, time=2020-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802582, encodeId=fcf78025823d, content=但是间隔时间长呢？如果抗体滴度下降到某种水平，就不会有抵抗剂, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Jul 12 11:05:17 CST 2020, time=2020-07-12, status=1, ipAttribution=)]
2020-07-14 jichang

#SCIE#

24 0
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2020-07-14 12498b37m78暂无昵称

#抵抗力#

22 0
[GetPortalCommentsPageByObjectIdResponse(id=1937934, encodeId=5e73193e93402, content=<a href='/topic/show?id=02de15902d3' target=_blank style='color:#2F92EE;'>#SARS-CoV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15902, encryptionId=02de15902d3, topicName=SARS-CoV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sun Jul 19 10:44:22 CST 2020, time=2020-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1993696, encodeId=70a2199369605, content=<a href='/topic/show?id=00502394328' target=_blank style='color:#2F92EE;'>#二次感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23943, encryptionId=00502394328, topicName=二次感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1dbc2500219, createdName=huagfeg, createdTime=Sat Dec 19 10:44:22 CST 2020, time=2020-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809045, encodeId=5dc88090452a, content=有效果吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200815/bc57614038034f80b4a141a3adf50037/ec920323764b4e5f8406b52ac100df3f.jpg, createdBy=f48e5151422, createdName=Dolly66, createdTime=Sat Aug 15 03:19:18 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321200, encodeId=cecc132120057, content=<a href='/topic/show?id=ac0d159007f' target=_blank style='color:#2F92EE;'>#SARS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15900, encryptionId=ac0d159007f, topicName=SARS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8306486, createdName=小刀医生, createdTime=Tue Jul 14 01:44:22 CST 2020, time=2020-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376127, encodeId=851913e61275b, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Tue Jul 14 01:44:22 CST 2020, time=2020-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616320, encodeId=abef16163201a, content=<a href='/topic/show?id=6f855608584' target=_blank style='color:#2F92EE;'>#抵抗力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56085, encryptionId=6f855608584, topicName=抵抗力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47f119741723, createdName=12498b37m78暂无昵称, createdTime=Tue Jul 14 01:44:22 CST 2020, time=2020-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802582, encodeId=fcf78025823d, content=但是间隔时间长呢？如果抗体滴度下降到某种水平，就不会有抵抗剂, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Jul 12 11:05:17 CST 2020, time=2020-07-12, status=1, ipAttribution=)]
2020-07-12 lovetcm

但是间隔时间长呢？如果抗体滴度下降到某种水平，就不会有抵抗剂

75 0

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